A5036056964- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Nanoplatforms for cancer theranostics
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Cancer Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Metastasis and carcinoma case studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Gastrointestinal Tumor Research and Treatment
- Nanocluster Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Extracellular vesicles in disease
- Intraperitoneal and Appendiceal Malignancies
- Parkinson's Disease Mechanisms and Treatments
- Ultrasound and Hyperthermia Applications
- Gastric Cancer Management and Outcomes
- Ultrasound and Cavitation Phenomena
- Nuclear Receptors and Signaling
- Bone health and treatments
- Fibroblast Growth Factor Research
- BRCA gene mutations in cancer
Sichuan University
2017-2025
Xiamen University
2020-2024
West China Hospital of Sichuan University
2017-2024
Guiyang Medical University
2018-2024
Affiliated Hospital of Guizhou Medical University
2018-2024
Capital Medical University
2023-2024
Beijing Tian Tan Hospital
2023-2024
National Clinical Research Center for Digestive Diseases
2023
Chinese Institute for Brain Research
2023
State Key Laboratory of Biotherapy
2017-2022
Abstract Lung cancer has the highest mortality rate among human cancers, and majority of deaths can be attributed to metastatic spread. stem cells (CSCs) are a component tumour microenvironment that contributes this process. Exosomes small membrane vesicles secreted by all types mediate cell interactions, including metastasis. Here, we show lung CSC‐derived exosomes promote migration invasion cells, up‐regulate expression levels N‐cadherin, vimentin, MMP‐9 MMP‐1, down‐regulate E‐cadherin...
Zoledronic acid is the most potent osteoclast inhibitor and widely used for advanced cancer patients with bone metastasis, but its role on stem cells (CSCs) remains unclear. In present study, we aimed to identify stemness phenotypic characteristics of CSCs derived from cervical explore anti-cancer efficiency zoledronic these cells, as well possible molecular mechanisms.Stemness identification was performed via sphere formation (SFE), tumorigenesis, immunofluorescence staining, Transwell...
Systemic inflammation plays an important role in the pathophysiology and progression of aneurysmal subarachnoid hemorrhage (aSAH). In this study, we aimed to investigate association between a new biomarker, inflammatory burden index (IBI) prognosis as well in-hospital complications aSAH patients.We analyzed data from patients with January 2019 September 2022 who were included LongTEAM (Long-term Prognosis Emergency Aneurysmal Subarachnoid Hemorrhage) registry study. The IBI was formulated...
Epithelial-mesenchymal transition (EMT) is a crucial driver of tumor progression. Tumor growth factor-beta 1 (TGF-β1) an important factor in EMT induction tumorigenesis. The targeting may, therefore, represent promising approach anticancer treatment.In this study, we determined the effect decitabine, DNA methyltransferase inhibitor, on TGF-β1-induced non-small-cell lung cancer (NSCLC) PC9 and A549 cells. We also assessed involvement miR-200/ZEB axis.Decitabine reversed cells, but not This...
Self-recognizing and stimulus-responsive carrier-free metal-coordinated nanotheranostics with a robust structure could achieve multi-modal imaging-guided synergistic photo-chemotherapy.
Early systemic inflammatory changes are increasingly recognized as factors influencing outcomes after aneurysmal subarachnoid hemorrhage (aSAH). Systemic inflammation response index (SIRI), an biomarker, was thought to be associated with adverse in many other diseases. However, aSAH, research on SIRI remains limited. Thus, our objective investigate the association between and poor long-term functional while evaluating mediating role of in-hospital complications this association.
Molybdenum disulfide quantum dots (MoS2 QDs) represent an emerging class of two-dimensional (2D) atomically layered transition metal dichalcogenide nanostructures with few nanometers in lateral size, which show attractive potential as versatile platforms for theranostic applications various neurological disorders. However, the impacts MoS2 QDs on microglia remain unclear. In this report, we showed that exposure to triggered NLRP3 inflammasome activation revealed by cleavage inactive...
Abstract Background Intraperitoneal paclitaxel is proved to be efficient for peritoneal metastasis of gastric cancer. It remains uncertain the efficacy and safety triplets regimen which combined intraperitoneal high‐dose with systemic SOX in cancer patients metastasis. This study aimed evaluate administration paclitaxel, intravenous oxaliplatin S‐1 metastatic Methods single‐center, prospective, single‐arm phase II was conducted between January 2017 May 2019 West China Hospital, Sichuan...
Background: Breast cancer is the leading cause of mortality from in women worldwide, and stem-like cell (CSC) responsible for failure treatment breast cancer. It plays an important role resistant disease metastasis. CD44/CD24 ALDH are well-accepted protein markers CSC, it was reported that distinct subtypes CSC were identified by 2 markers. possible there various kinds which could be different markers, utilized at present not enough to fully understand CSC. Finding out more novel necessary....
This research was aimed to investigate the effects of baicalin on 6-hydroxydopamine (6-OHDA)-induced rat model Parkinson's disease (PD) and main mechanism based metabolomics.The PD induced by 6-OHDA. The protective were evaluated open field test rotarod test. anti-PD efficacy examining morphologic changes neurons level monoamine neurotransmitters in striatum, number morphology tyrosine hydroxylase (TH)-positive neurons, oxidative stress. Combined with metabolomics methods, pharmacodynamic...
Abstract Induction chemotherapy treatment for nasopharyngeal carcinoma (NPC) is controversial. The aim of this study was to evaluate the outcomes and toxicities between two induction regimens, with both followed by concurrent chemoradiotherapy. first strategy used docetaxel, cisplatin fluorouracil (TPF), second utilised gemcitabine (GP). A retrospective analysis performed on eligible NPC patients attending our hospital May 2009 Dec 2014. total 113 were enrolled 58 receiving TPF 55 GP...
Objectives Early brain injury (EBI) is considered to be one of the main causes poor outcome in subarachnoid hemorrhage (SAH) patients. Bexarotene an agonist retinoid X receptor and plays a protective role central nervous system diseases. However, exact bexarotene SAH has not been reported. Therefore, present study was determine whether administration attenuate EBI after mice explore underlying mechanism. Methods induced C57BL/6 by endovascular perforation. administrated intraperitoneally....
Breast and colonic carcinomas are two main origins of metastatic liver cancer. Chemotherapy, which introduces various anticancer drugs such as paclitaxel, is an important cure for patients who not suitable surgery transcatheter hepatic arterial chemoembolization. However, the poor water solubility serious side effects have limited use paclitaxel. Nanoparticles promising carriers paclitaxel to overcome these limitations. Besides, relatively consistent drug absorption by peritoneum into...