A5039625672- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Metabolomics and Mass Spectrometry Studies
- Birth, Development, and Health
- Microplastics and Plastic Pollution
- Traditional Chinese Medicine Analysis
- Per- and polyfluoroalkyl substances research
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Mass Spectrometry Techniques and Applications
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Pesticide Residue Analysis and Safety
- Plant Stress Responses and Tolerance
- Pediatric Hepatobiliary Diseases and Treatments
- Bariatric Surgery and Outcomes
- Analytical Chemistry and Chromatography
- Cancer, Hypoxia, and Metabolism
- Gestational Diabetes Research and Management
- Recycling and Waste Management Techniques
- Dysphagia Assessment and Management
- Ginseng Biological Effects and Applications
- Metabolism and Genetic Disorders
- Air Quality and Health Impacts
Nankai University
2010-2025
Shandong University of Technology
2024
Jilin Electric Power Research Institute (China)
2024
Hong Kong Baptist University
2015-2023
Zhongshan People's Hospital
2021
Tianjin Nankai Hospital
2010-2020
University of Benin
2020
Tianjin Medical University
2014-2018
Army Medical University
2012-2016
State Key Laboratory of Medicinal Chemical Biology
2012-2014
The use of yellow sticky traps is a green pest control method that utilizes the pests’ attraction to color yellow. not only controls populations but also enables monitoring, offering more economical and environmentally friendly alternative pesticides. However, small size dense distribution pests on lead lower detection accuracy when using lightweight models. On other hand, large models suffer from longer training times deployment difficulties, posing challenges for in field edge computing...
Triclosan (TCS), an extensively used antimicrobial agent, has raised considerable concern due to its hepatocarcinogenic potential. However, previous hepatotoxicity studies primarily focused on the activation of specific intracellular receptors, underlying mechanisms still warrant further investigation at metabolic level. Herein, we applied metabolomics in combination with lipidomics unveil TCS-related responses human normal and cancerous hepatocytes. Endogenous exogenous metabolites were...
Occupational workers are usually exposed to high levels of per- and polyfluoroalkyl substances (PFASs), placing them under greater health risks compared the general population. Herein, 40 occupational from a factory in China 52 control subjects population were involved an investigation on potential concerns exposure PFASs by mass spectrometry-based metabolomics analysis. The PFAS plasma both groups analyzed. Six congeners (∑6PFASs) found be main components 13 detected PFASs, with geometric...
Benzophenones (BPs), parabens, and triclosan (TCS) are widely used in personal care products may be neurotoxic to children, but limited studies have estimated the associations between exposure these potential endocrine disrupting chemicals during pregnancy child neurocognitive development. Our aim was evaluate relationships of prenatal BPs, parabens TCS with development at age 2. From 2014 2015, 478 mother-child pairs from a longitudinal cohort China were included present study. We...
Phthalates are a family of endocrine disruptors with short elimination half-lives in the human body. To date, few epidemiological studies have examined repeated measures maternal urinary phthalates and combined effects prenatal exposure to multiple on children's neurocognitive development.We aimed investigate association between development at 2 years age phthalate exposure, as assessed by measurements during pregnancy, further examine co-exposure using cumulative risk assessment.Within...
Nanoplastics (NPLs) are widespread in our environment. However, their impacts on human health and precise toxicity mechanisms remain poorly understood. Here we studied the internalization, release, cytotoxicity of polystyrene nanoplastics (PSNPs) using renal tubular epithelial cell line HKC derived liver HL-7702. We also employed an integrated proteomic metabolomic approach to investigate potential biological effects PSNPs cells. The abundances 4770 proteins 100 metabolites were quantified,...
SIRT1 is a multifaceted NAD+-dependent protein deacetylase known to act as tumor promoter or suppressor in different cancers. Here, we describe novel mechanism of SIRT1-induced hepatocellular carcinoma (HCC) metastasis. overexpression was frequently detected human HCC specimens and associated with microvascular invasion (P = 0.0039), advanced node metastasis (TNM) stages 0.0016), recurrence 0.021) poor outcomes 0.039). Lentivirus-mediated knockdown MHCC97H cells reduced vitro vivo. depletion...
Bisphenol S (BPS) and bisphenol F (BPF) are increasingly used in manufacturing consumer products to replace the use of A (BPA), but exposure data limited, particularly among pregnant women. Here, we measured BPA, BPS, BPF levels urine samples, collected from 941 women over three trimesters. We examined correlations, coexposure patterns, variability, predictors bisphenols using Spearman's correlation coefficient, percentile analysis, intraclass linear mixed models, respectively. assessed...
The objective of this study was to evaluate the efficacy combined therapy using Sorafenib and radiofrequency ablation (RFA) with curative intent for all detectable lesions in patients Barcelona Clinic Liver Cancer (BCLC) Stage 0-B1 hepatocellular carcinoma (HCC).One hundred twenty-eight HCC from 12 centers were enrolled retrospective study; 64 who received plus RFA (Sorafenib-RFA) compared a control group treated alone. two patient groups selected predefined criterion matched terms their...
Widespread exposure to parabens has been a concern, especially among pregnant women. Only one study reported that are associated with glucose levels However, studies on and gestational diabetes mellitus (GDM) lacking.This investigated whether in early pregnancy is related GDM.We conducted prospective of 1087 women from single tertiary medical center between 2014 2015 Wuhan, China. Parabens [methyl paraben (MeP), ethylparaben (EtP), propylparaben (PrP), butylparaben (BuP), benzylparaben...
BACKGROUND: Bisphenol A (BPA) is an endocrine disruptor that affects fetal growth in experimental studies.Bisphenol F (BPF) and bisphenol S (BPS), which have been substituted for BPA some consumer products, also shown endocrine-disrupting effects models.However, the of BPF BPS on humans are unknown.OBJECTIVES: Our goal was to investigate trimester-specific associations urinary concentrations BPA, BPF, with size at birth.METHODS: The present study included 845 pregnant women from Wuhan, China...
Despite the increasing research attention paid to gestational diabetes mellitus (GDM) due its high prevalence, limited knowledge is available about pathogenesis. In this study, 428 serum samples were collected from 107 pregnant women suffering GDM and matched healthy controls. The nontargeted metabolomics data of maternal first (T1, n = 214) second trimesters (T2, acquired by using ultrahigh performance liquid chromatography coupled with Orbitrap mass spectrometry (MS). A total 93...
Polycyclic aromatic hydrocarbon (PAH) exposure is suspected to be linked oxidative damage. Herein, ten PAH human biomarkers [hydroxylated metabolites (OH-PAHs)] and five stress (OSBs) were detected in urine samples collected from participants living a rural area (n = 181) Northwestern China. The median molar concentration of ΣOH-PAHs was 47.0 pmol mL–1. 2-hydroxynaphthalene (2-OHNap; median: 2.21 ng mL–1) the dominant OH-PAH. risk assessment found that hazard index (HI) values <1, indicating...
Parabens are widely used as common preservatives in the pharmaceutical and cosmetic industries. Exposure to parabens has been found be associated with metabolic alterations of human an increased risk disease, such diabetes. However, limited information is available about pathways related paraben exposure. In this study, three were determined urine samples 88 pregnant women by using ultrahigh-performance liquid chromatography coupled triple quadrupole mass spectrometry (UHPLC-QqQ MS). The...
Cadmium (Cd) and polycyclic aromatic hydrocarbons (PAHs) are prominent soil contaminants found in industrial sites, their combined effects on plants not yet fully understood. To investigate the mechanisms underlying co-exposure of Cd PAHs identify key biomarkers for co-effects, an integrated analysis metabolomics, transcriptomics, proteomics was conducted ryegrass leaves cultivated soil. In nontarget metabolomics analysis, nine differentially expressed metabolites that were specifically...
This study reports the initial experience with laparoendoscopic single-site (LESS) cholecystectomy and compares it laparoscopic (LC) through a randomized controlled trial. Sixty selective patients diagnosed cholelithiasis or polyp lesion of gallbladder (PLG) were randomly divided into two groups undergoing either LESS LC separately. The clinical data about operations recovery compared. In group 28 30 underwent successfully remaining (6.7%) converted to standard surgery. was performed in all...