A5081477180- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Biliary and Gastrointestinal Fistulas
- Liver Disease Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Liver Disease and Transplantation
- Cancer, Hypoxia, and Metabolism
- Esophageal Cancer Research and Treatment
- Mobile Health and mHealth Applications
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Pancreatitis Pathology and Treatment
- Cancer-related Molecular Pathways
- Enhanced Recovery After Surgery
- Pathogenesis and Treatment of Hiccups
- Metastasis and carcinoma case studies
Air Force Medical University
2015-2024
Xijing Hospital
2015-2024
National Clinical Research Center for Digestive Diseases
2018-2024
Nanjing Drum Tower Hospital
2023
National Research Institute of Brewing
2017
INTRODUCTION: Vagal nerve stimulation (VNS) can be used to modulate gastrointestinal motility, inflammation, and nociception. However, it remains unclear whether VNS is effective in adult patients with functional dyspepsia (FD). We investigated the effectiveness of transcutaneous auricular (taVNS) FD. METHODS: Consecutive FD meeting Rome IV criteria modified Symptom Diary score ≥10 were enrolled. Patients randomly allocated 10-Hz taVNS (V10 group), 25-Hz (V25 or sham group, 30 minutes...
Abstract Low oxygen tension can influence tumor progression by enhancing angiogenesis, a process that may involve Rho GTPases whose activities have been implicated in tumorigenesis and metastasis. In the present study, we show hypoxia increase mRNA levels intracellular of Rac1 Cdc42 time‐dependent manner. The hypoxia‐stimulated could be blocked phosphatidylinositol 3′‐kinase (PI3K) inhibitor LY294002 protein tyrosine kinase (PTK) genistein but were not affected p38MAPK SB203580 or MEK‐1...
INTRODUCTION: Up to 60% of patients with common bile duct stone (CBDS) recurrence suffer from further after endoscopic retrograde cholangiopancreatography (ERCP). There are no effective methods prevent in most patients. In this study, we aimed assess the short-term and long-term efficacies papillary large balloon dilation (EPLBD) for management recurrent CBDS a randomized controlled trial. METHODS: Consecutive were eligible randomly assigned 1:1 ratio EPLBD group or control group. The...
Moderate-to-severe post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis contributes to most of the poor outcomes patients with post-ERCP (PEP). However, it remains unclear which part patient is more vulnerable moderate-to-severe PEP (MS PEP). In this study, we aimed identify risk factors independently associated MS PEP.Consecutive native papilla who had undergone ERCP were included in study. The patient-related and procedure-related variables retrieved from a prospectively...
Plastic and covered metal stents need to be removed or exchanged within appropriate time in case of undesirable complications. However, it is not uncommon that patients do follow the recommendation for further stent management after Endoscopic Retrograde Cholangiopancreatography (ERCP). The effect short message service (SMS) intervention monthly on removal/exchange adherence ERCP unknown at this time. A prospective, randomized controlled study was conducted. After receiving regular...
Abstract Background The 5–5–1 criteria (> 5 minutes – cannulation attempts 1 unintended pancreas duct cannulation) were proposed by the European Society of Gastrointestinal Endoscopy to define difficult biliary cannulation. However, may be inappropriate for trainee-involved procedures. We developed in Methods Patients undergoing with or without trainee involvement eligible. Procedures that might too easy (e. g. fistula) altered anatomy) excluded. primary outcome was cannulation, defined...
Background Previous cross-sectional studies have identified multiple potential risk factors for functional dyspepsia (FD). However, the causal associations between these and FD remain elusive. Here we aimed to fully examine relationships utilizing a two-sample MR framework. Methods A total of 53 FD-related modifiable factors, including those associated with hormones, metabolism, disease, medication, sociology, psychology, lifestyle others were obtained through comprehensive literature...
We have efficiently generated the first monoclonal antibody (MAb) against human ZNRD1 protein, a transcription-associated consisting of two zinc ribbon domains. Hybridomas were screened by indirect enzyme-linked immunosorbent assay (ELISA) using either purified 6 × His-ZNRD1fusion protein or His-OS-9 fusion as control. One MAb named H6 (IgG1), effective in detecting recombinant and cellular was characterized ELISA Western immunoblotting. Thus, it binds to native should be useful studies...
Background: Air cholangiogram has been used in patients with malignant hilar obstruction to reduce cholangitis after endoscopic retrograde cholangiopancreatography (ERCP). However, it still remains unclear whether CO2 could be as an alternative for air cholangiography such patients. Objective: To investigate the effect of on post-ERCP complications. Design: Prospective, randomized controlled study. Setting: Tertiary care referral center. Patients: 36 Bismuth type II, III or IV were into...
Surgical management of gastric gastrointestinal stromal tumors (GISTs) has evolved towards minimal invasiveness. Laparoscopic wedge resection and laparoscopic endoscopic cooperative surgery had been considered as standard surgical treatments for GISTs > 2 cm. However, stomach deformation the full-thickness defect caused by these procedures may increase risk morbidity. To address problems, we developed a novel technique, third space robotic (TS-RECS), which could dissect tumor entirely while...
Irritable bowel syndrome (IBS) is a common functional disease that shares features with many organic diseases and cannot be accurately diagnosed by symptom-based criteria. Alarm symptoms have long been applied in the clinical diagnosis of IBS. However, no study has explored predictive value alarm suspected IBS patients based on latest Rome IV criteria.To investigate criteria.In this multicenter cross-sectional study, we collected data from 730 evaluated at 3 tertiary care centers August 2018...
INTRODUCTION: Although the Rome criteria were created primarily for research purposes, it was an important question whether can distinguish organic dyspepsia from functional (FD). We evaluated accuracy of IV in identifying patients with FD and compared differences between IV, III, potential Asia FD. METHODS: In this cross-sectional study, we analyzed data who met inclusion exclusion March 2018 to January 2019 at 2 tertiary hospitals. RESULTS: A total 600 enrolled including 381 individuals...
Functional dyspepsia symptom diary (FDSD) is a newly designed questionnaire of functional (FD). The relationships between FDSD and other FD-related questionnaires patient-reported severity remain unclear. This study aims to investigate the correlations determine FD severity.Consecutive outpatients with were prospectively enrolled in four tertiary hospitals. All patients evaluated by six questionnaires, including FDSD, Dyspepsia Symptom Severity Index (DSSI), Gastrointestinal Rating Scale,...
Objective: DNA damage response (DDR) deficiency has emerged as a prominent determinant of tumor immunogenicity. This study aimed to construct DDR-related immune activation (DRIA) signature and evaluate the predictive accuracy DRIA for checkpoint inhibitor (ICI) therapy in gastrointestinal (GI) cancer. Methods: A was established based on two previously reported assays. Clinical gene expression data from published GI cancer cohorts were used assess validate association between score ICI...
Rectal indomethacin and pancreatic duct stenting (PDS) are recommended for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP). However, effects combination two methods on preventing PEP controversial. We hypothesized that some group difficult patients might benefit from plus PDS (IP) compared with alone (IN).Patients native papilla who underwent endoscopic in eight tertiary hospitals were screened. They enrolled if cannulation proved post-procedure was...