A5100611970- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Tracheal and airway disorders
- Renal cell carcinoma treatment
- Abdominal vascular conditions and treatments
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Venous Thromboembolism Diagnosis and Management
- Head and Neck Cancer Studies
- Aortic aneurysm repair treatments
- Acupuncture Treatment Research Studies
- MRI in cancer diagnosis
- Esophageal and GI Pathology
- Cancer-related molecular mechanisms research
- Hepatitis Viruses Studies and Epidemiology
- Tryptophan and brain disorders
- Antioxidant Activity and Oxidative Stress
- RNA Interference and Gene Delivery
- Vascular anomalies and interventions
- Brain Metastases and Treatment
- Lung Cancer Research Studies
First Affiliated Hospital of Zhengzhou University
2013-2023
Air Force Medical University
2023
Xijing Hospital
2023
Southern Medical University
2023
Nanfang Hospital
2023
Shandong University of Traditional Chinese Medicine
2023
National Clinical Research Center for Digestive Diseases
2023
Jiangmen Central Hospital
2014-2022
Chongqing Medical University
2022
Shanxi Medical University
2018-2020
Objectives Early placement of transjugular intrahepatic portosystemic shunt (TIPS) has been shown to improve survival in high-risk patients (Child-Pugh B plus active bleeding at endoscopy or Child-Pugh C 10–13) with cirrhosis and acute variceal (AVB). However, early TIPS criteria may overestimate the mortality risk a significant proportion patients, benefit conferred by such questioned. Alternative have proposed refine used identify candidates for TIPS. Nevertheless, true provided (or not)...
Abstract Growing evidence has indicated that circular RNAs (circRNAs) play a pivotal role as functional in diverse cancers. However, most circRNAs involved esophageal squamous cell carcinoma (ESCC) remain undefined, and the underlying molecular mechanisms mediated by are largely unclear. Here, we screened human circRNA expression profiles ESCC tissues found significantly increased of hsa_circ_0000277 (termed circPDE3B) lines compared to normal controls. Moreover, higher circPDE3B patients...
Aim: This study aimed to report the efficacy and safety of trans -arterial chemoembolization (TACE) plus lenvatinib camrelizumab in patients with advanced hepatocellular carcinoma (HCC). Methods: retrospective enrolled 22 HCC from March 2018 December 2019. All received comprehensive treatment TACE followed by camrelizumab. Overall survival (OS) progression-free (PFS) were calculated analysed using Kaplan-Meier method log-rank test. Treatment response adverse events (AEs) also evaluated....
Antibacterial and antihyperplasia airway stents are highly desirable for tracheal stenosis. Herein, a series of polylactic acid (PLA) silver nanoparticles (AgNPs) nanofiber membranes (PLA, PLA-4 %AgNPs PLA-6 % AgNPs) were prepared by electrospinning. The physicochemical biological properties the resultant examined. SEM drug release results indicated that AgNPs successfully introduced into PLA, could be sustained to released from membranes. showed antibacterial activity against S. aureus P....
To evaluate the type of venous involvement in Chinese Budd-Chiari syndrome (BCS) patients and relative diagnostic accuracy different imaging modalities.Using digital subtraction angiography (DSA) as a reference standard, color Doppler ultrasound (CDUS), computed tomography (CTA), magnetic resonance (MRA) were performed on 338 with BCS. We analyzed course main any accessory hepatic veins (HVs) inferior vena cava (IVC) to assess etiology obstructed segments CDUS, CTA MRA.Among cases, there 8...
Background and Aims Optimal candidates for early transjugular intrahepatic portosystemic shunt (TIPS) in patients with Child‐Pugh B cirrhosis acute variceal bleeding (AVB) remain unclear. This study aimed to test the hypothesis that risk stratification using Chronic Liver Failure Consortium Acute Decompensation score (CLIF‐C ADs) may be useful identify a subgroup at high of mortality or further benefit from TIPS AVB. Approach Results We analyzed pooled individual data two previous studies...
The restenosis following percutaneous transluminal balloon angioplasty (PTBA) is high for Budd-Chiari syndrome (BCS) patients with hepatic venous obstruction (HVO). We aim to evaluate the safety and long-term outcome of PTBA a large catheter in series HVO.Between January 2005 December 2013, 93 consecutive BCS HVO were referred subsequently underwent color Doppler ultrasonography or angiography follow-up. Data retrospectively collected, follow-up observations performed at 1-, 2-, 2- 5-, 5-...
The objective of this study was to investigate the effects and molecular mechanisms total flavonoids from Cortex Juglandis Mandshuricae (TFC) on preventing alcohol-induced chronic liver injury regulating gut microbiota in mice. results showed that oral administration TFC significantly attenuated alcoholic improved lipid accumulation mice with through activation AMPK/PPARα pathway. In addition, maintained integrity intestinal barrier mice, reducing endotoxin leakage intestine further...
beta-Amyloid (Abeta) is strongly involved in the pathogenesis of Alzheimer's disease (AD), and mitochondria play an important role neurodegenerative disorders. To determine whether any different effect melatonin on cultured neurons treated with Abeta vitro which may be produced through its action at stages culture, we investigated damage rat hippocampal mitochondrial function induced by young [days 10 (DIV 10)] senescent 25) protective melatonin. Rat were incubated amyloid-beta peptide 25-35...
Excessive plasma triglyceride (TG) and cholesterol levels promote the progression of several prevalent cardiovascular risk factors, including atherosclerosis, which is a leading death cause. Perilipin 5 (Plin5), an important perilipin protein, abundant in tissues with very active lipid catabolism involved regulation oxidative stress. Although inflammation stress play critical role atherosclerosis development, underlying mechanisms are complex not completely understood. In present study, we...
The goal of this study was to determine the clinical efficacy and safety drug-eluting bead (DEB) transarterial chemoembolization (TACE) in combination with apatinib administration patients advanced hepatocellular carcinoma (HCC).From December 2015 May 2017, a total 32 HCC treated DEB-TACE combined were consecutively enrolled study. treatment response laboratory outcomes assessed at first- third month after therapy. Overall survival, progression-free adverse events also analyzed assessed.The...
Abstract Purpose Raltitrexed shows therapeutic effects and safety in many types of malignant tumors. However, reports the clinical outcomes raltitrexed-based transarterial chemoembolization (TACE) or drug-eluting beads TACE (DEB-TACE) treatment hepatocellular carcinoma (HCC) are rare. We aim to report preliminary DEB-TACE loaded with raltitrexed patients unresectable recurrent HCC. Methods From June 2018 March 2020, 29 HCC were recruited from our department treated by raltitrexed. Overall...
Aim: The aim of this study is to determine the efficacy and safety combination therapy drug-eluting bead bronchial arterial chemoembolization plus anlotinib oral administration in treatment non-small-cell lung cancer (NSCLC). Methods: Consecutive data from 51 patients with advanced NSCLC were retrospectively collected February 2018 August 2019. All underwent (DEB-BACE) followed by treatment. Overall survival (OS) progression-free (PFS) calculated analyzed using Kaplan-Meier method log-rank...
Abstract Hepatic stellate cell is one of the major nonparenchymal types in liver. It has been proved hepatic cells are activated upon liver injury and produce excessive extracellular matrix to induce fibrosis. Single-cell RNA sequencing introduced identify subpopulations function for its remarkable resolution representation single-cell transcriptome. According re-analysis data pseudotime trajectory inference, we have found C-type lectins including Colec10 Colec11 not produced by hepatocytes...
To assess the clinical value of drug-eluting bead trans-arterial chemoembolization (DEB-TACE) combined with microwave ablation (MWA) vs. MWA treatment alone for early stage hepatocellular carcinoma (HCC).Consecutive data from 102 HCC patients at who were referred to our hospital December 2014 May 2016 retrospectively collected. Forty-seven underwent DEB-TACE treatment, whereas 55 alone. After 1 month tumour responses assessed using mRECIST criteria. Treatment-related complications and...