A5006256751- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Circular RNAs in diseases
- RNA modifications and cancer
- Galectins and Cancer Biology
- Hepatitis B Virus Studies
- Chronic Lymphocytic Leukemia Research
- Cervical Cancer and HPV Research
- Monoclonal and Polyclonal Antibodies Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Pediatric Hepatobiliary Diseases and Treatments
- Management of metastatic bone disease
- Reproductive System and Pregnancy
- Cancer Research and Treatments
- Lymphoma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Endometrial and Cervical Cancer Treatments
- Radiopharmaceutical Chemistry and Applications
- Hepatitis C virus research
- Medical Imaging and Pathology Studies
- Systemic Lupus Erythematosus Research
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
First Affiliated Hospital of Zhengzhou University
2019-2024
National Medical Products Administration
2023-2024
Peking University Cancer Hospital
2023-2024
Peking University
2023-2024
Dalian University
2024
First Hospital of Jiaxing
2024
Southern Medical University
2021-2023
Nanfang Hospital
2021-2023
Affiliated Hospital of Qingdao University
2015-2022
Qingdao University
2015-2022
Refractoriness to surgical resection and chemotherapy makes intrahepatic cholangiocarcinoma (ICC) a fatal cancer of the digestive system with high mortality poor prognosis. Important function invests circRNAs tremendous potential in biomarkers therapeutic targets. Nevertheless, it is still unknown how contribute evolution ICC. CircRNAs paired ICC adjacent tissues were screened by sequencing. To explore impact on development, experiments involving gain loss conducted. Various experimental...
Tumor markers are beneficial for the diagnosis and therapy monitoring of lung cancer. However, value tumor in cancer histological is unknown. In this study, we analyzed serum levels six (CEA, CYFRA21-1, SCC, NSE, ProGRP, CA125) 2097 suspected patients with determined whether combination was useful We found that CYFRA21-1 most sensitive marker NSCLC. ProGRP showed a better clinical performance than NSE discriminating between SCLC The level or SCC significantly higher squamous carcinoma...
Abstract Introduction Previous studies of anti‐dsDNA, nucleosome (Nucl), histone (His), and C1q antibodies have revealed their clinical value in systemic lupus erythematosus (SLE). However, the correlation between four autoantibodies SLE activity, nephritis (LN) remains controversial, data are insufficient on longitudinal monitoring. This study aimed at evaluating these active LN, performance cross‐sectional monitoring disease activity. Methods Serum levels 114 patients, 219 other autoimmune...
// Ahmed Lasfar 1, 2 , Andrew de la Torre 3, 4 Walid Abushahba 5 Karine A. Cohen-Solal 2, 6 Ismael Castaneda 3 Yao Yuan 7 Kenneth Reuhl Zloza Elizabeth Raveche Debra L. Laskin Sergei V. Kotenko 1 Department of Pharmacology and Toxicology, Ernest Mario School Pharmacy, Rutgers, the State University New Jersey, Piscataway, NJ, USA Rutgers Cancer Institute Brunswick, Surgery, Jersey Medical School, The Newark, St Joseph's Center, Paterson, Microbiology, Biochemistry Molecular Genetics, Center...
Allergic asthma is the most prevalent phenotype and associated with disorders of immune cells glycolysis. Macrophages are common type in lungs. Calprotectin (S100A8 S100A9) two pro-inflammatory molecules that target Toll-like receptor 4 (TLR4) substantially increased serum patients severe asthma. This study aimed to determine effects S100A8/A9 on macrophage polarization glycolysis allergic
e15003 Background: Antibody-drug conjugates (ADCs) have shown substantial promise as therapies for metastatic breast cancer (mBC). However, direct comparisons of different ADC-based regimens are limited. We assessed survival outcomes in mBC patients treated with ADCs. Methods: Randomized controlled trials (RCTs) published before October 2024 were searched Medline, Embase, ClinicalTrials.gov, and Cochrane Library. Progression-free (PFS) overall surcvival (OS) extracted from the most updated...
e15015 Background: Antibody-drug conjugates (ADCs) have demonstrated significant efficacy in treating patients with breast cancer. However, the toxicity variations between these agents are not yet thoroughly elucidated. This study aims to systematically compare profiles of various ADCs used cancer therapy better inform clinical decision-making. Methods: We conducted a systematic review randomized controlled trials (RCTs) published by September 2024. Treatment-related adverse events (TRAEs)...
// Bin Wu 1 , Yuan Yao 2 Ke Zhang 3 and Xuezhen Ma 4 Medical Decision Economic Group, Department of Pharmacy, Ren Ji Hospital, South Campus, School Medicine, Shanghai Jiaotong University, Shanghai, P.R. China Laboratory, The Affiliated Hospital Qingdao Qingdao, Shandong, Oncology, Commercial Worker's Central Second University College, Correspondence to: Ma, email: maxuezhen1968@tom.com Keywords: colorectal cancer, cost-effectiveness, cetuximab, gene mutation Received: August 12, 2016...
Background Chromodomain helicase/ATPase DNA-binding protein 1-like gene (CHD1L), also known as ALC1 (amplified in liver cancer 1 gene), is a new oncogene amplified many solid tumors. Whether this plays role invasion and metastasis of breast unknown. Methods Immunohistochemistry was performed to detect the expression CHD1L patients with invasive ductal carcinoma normal mammary glands. Chemotaxis, wound healing, Transwell assays were examine cell migration invasion. Western blot analysis...
Objective: To analyze the clinical characteristics, risk factors for critical illness and death of severe adenovirus pneumonia in children, so as to provide evidences early diagnosis reliable treatment. Methods: A total 75 pediatric cases with admitted Tongji Hospital, Medical College, Huazhong University Science Technology from January October 2019 were studied. The features, laboratory imaging data, therapeutic approaches, efficacy treatments prognosis investigated retrospectively....
Abstract IL-27 could inhibit the development of Th17 cells, and Th17/regulatory T-cell imbalance may reverse maternal tolerance in pre-eclampsia (PE). The aim this study was to investigate association between genetic polymorphisms IL27 with PE. Three SNPs (rs153109, rs17855750, rs181206) were genotyped a Chinese Han cohort 1040 PE patients 1247 normal pregnant women using TaqMan allelic discrimination real-time PCR method. CC genotypic distribution rs153109 significantly higher among cases...
Objective Primary biliary cholangitis (PBC) is an autoimmune disease with significant gender difference. X chromosome inactivation (XCI) plays important roles in susceptibility to diseases between genders. This work focuses on the differences of LncRNA XIST several defined immune cells populations as well its effects naive CD4+ T proliferation and differentiation patients PBC. Methods NKs, B cells, T, CD8+ were separated by MicroBeads from peripheral blood mononuclear (PBMCs) PBC healthy...
To identify genomic markers associated with the response to neoadjuvant chemotherapy (NACT) in patients cervical cancer, we performed a three-stage genome-wide association study (GWAS) Han Chinese population. A total of 596 stage IA2-IIIB cancer were enrolled this study. One single nucleotide polymorphism (SNP) (rs6812281, per allele OR = 2.37, P 9.0 × 10-9) located at 4q34.3 reached GWAS significance (P < 5.0 10-8). Another three SNPs, rs4590782 (10q26.2, 1.59 10-5, 0.48), rs1742101...
Accumulating evidence has demonstrated that microRNAs (miRNAs or miRs) play an important role in the diagnosis and prognosis of tumors. In case cholangiocarcinoma (CCA), miRNAs may serve as potential tumor biomarkers therapeutic targets. Based on The Cancer Genome Atlas (TCGA) database, fold change >2 was used to screen out with differential expression patients CCA. Univariate multivariate Cox regression analyses identified miR-3913-5p independent prognostic factor Overall survival...
Abstract Background: Similar to a subset of human patients who progress from monoclonal B lymphocytosis (MBL) chronic lymphocytic leukemia (CLL), New Zealand Black (NZB) mice have an age‐associated progression CLL. The murine disease is linked genetic abnormality in microRNA mir‐15a/16‐1 locus, resulting decreased mature miR‐15a/16. Methods: Spleens aging NZB were analyzed for the presence B‐1 cells via flow cytometry and side population (SP) ability exclude Hoechst 33342 dye. SP was assayed...
Common blood disorders include hematopoietic cell malignancies or leukemias and plasma dyscrasia, all of which have associated microRNA abnormalities. In this paper, we discuss several including acute myeloid leukemia (AML) chronic lymphocytic (CLL) identify altered microRNAs their targets. Immune with levels antibodies autoimmune disorders, such as systemic lupus erythematosus (SLE) anti-self-autoantibodies immunoglobulin A nephropathy (IgAN) also related The alterations in may serve...