A5100710831- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Bariatric Surgery and Outcomes
- Ectopic Pregnancy Diagnosis and Management
- Maternal and fetal healthcare
- Chronic Kidney Disease and Diabetes
- Pancreatic function and diabetes
- Maternal and Perinatal Health Interventions
- Traditional Chinese Medicine Studies
- Uterine Myomas and Treatments
- Renal and Vascular Pathologies
- Hepatitis Viruses Studies and Epidemiology
- Airway Management and Intubation Techniques
- Abdominal Trauma and Injuries
- Traditional Chinese Medicine Analysis
- Vasculitis and related conditions
- Diabetes Treatment and Management
- Ocular Surface and Contact Lens
- COVID-19 Clinical Research Studies
- Entomopathogenic Microorganisms in Pest Control
- Pregnancy and Medication Impact
- Flavonoids in Medical Research
- Nosocomial Infections in ICU
- Heavy Metal Exposure and Toxicity
The First Affiliated Hospital, Sun Yat-sen University
2009-2025
Sun Yat-sen University
2009-2025
Affiliated Hospital of Southwest Medical University
2025
Affiliated Hospital of Qingdao University
2022-2024
Qingdao University
2022-2024
East China University of Science and Technology
2023
Yantai University
2023
Shandong First Medical University
2020
Guangdong Ocean University
2020
Shandong Provincial Hospital
2020
To date, the miRNA expression profile of plasma exosomes in women whose pregnancy is complicated by gestational diabetes mellitus (GDM) has not been fully clarified. In this study, differentially expressed miRNAs were identified high-throughput small-RNA sequencing 12 pregnant with GDM and normal glucose tolerance (NGT) validated 102 101 NGT. A total 22 exosomal found, five which verified real-time qPCR. Exosomal miR-423–5p was upregulated, whereas miR-122–5p, miR-148a-3p, miR-192–5p,...
The link between arsenic exposure and deficits in children's neurodevelopment has been suggested, but it remains unclear regarding the arsenic-related effects on developing brain early life. To investigate associations of utero with neonatal neurobehavioral development, we conducted a cross-sectional study 892 mother-infant pairs from 10 hospitals different levels Shanghai, China. concentrations were determined cord blood samples. Neurobehavioral measures administered at 3 days postpartum...
Abstract Context The significance of an early diagnosis gestational diabetes mellitus (GDM) with oral glucose tolerance test (OGTT) has not been determined. Objective objective this work is to investigate GDM diagnosed by and standard OGTTs determine adverse maternal neonatal outcomes associated diagnosis. Research Design Methods Early Diagnosis Gestational Diabetes Mellitus study a prospective cohort study. Each participant in the underwent 2 OGTTs, OGTT at 18 20 weeks (gws) 24 28 gws....
Background and AimsThe Triglyceride-Glucose Index (TyG) has been proposed as a predictor to mortality, yet its association remains incompletely understood for individuals with or without chronic kidney disease (CKD). Methods ResultsWe analyzed data from the National Health Nutrition Examination Survey spanning years 1999 2018.CKD was defined eGFR level < 60 ml/min/1.73m 2 urinary albumin creatinine ratio ≥ 30 mg/g.We employed Cox proportionalhazards model evaluate incident risk of mortality...
Objective To investigate the placental proteome differences between pregnant women complicated with gestational diabetes mellitus (GDM) and those normal glucose tolerance (NGT). Methods We used two-dimensional electrophoresis (2DE) to separate compare protein levels from GDM NGT groups. Differentially expressed proteins two groups were identified by MALDI-TOF/TOF mass spectrometry further confirmed Western blotting. The mRNA of related measured realtime RT-PCR. Immunohistochemistry (IHC) was...
Introduction A diagnosis of gestational diabetes mellitus (GDM) in low-risk pregnant women is based on an oral glucose tolerance test (OGTT) between 24 and 28 weeks. However, there insufficient evidence for why the performed this time period. Moreover, fetus may be exposed to hyperglycaemia prior current testing frame, making earlier administration potentially advantageous. The main purpose present study investigate GDM diagnostic value OGTT at 18–20 results provide scientific insight into...
Kawasaki disease (KD) can lead to coronary artery aneurysms (CAA) in approximately 1 5 untreated children despite intravenous immunoglobulin (IVIG) therapy the acute phase. The aim of this study is develop and validate an explainable machine learning (ML)-based prediction model for CAA KD. This retrospectively analyzed clinical data diagnosed with primary KD at Nanchong Central Hospital, Sichuan Province between 2015 2023. Six models, including support vector (SVM), K-nearest neighbors...
Aims Fasting plasma glucose (FPG) concentration measured at the first prenatal visit is a predictor of gestational diabetes mellitus (GDM); however, whether this test indicative fetal growth has not been clarified. Thus, purpose study was to determine birth weight and length were related FPG levels visit. Materials Methods Research samples collected from pregnant women who took an their (10–24 weeks), received regular care, delivered in our center. value, maternal pre-gravid BMI, gain before...
Hyperlipidemia and high fasting plasma glucose levels at the first prenatal visit (First Visit FPG) are both related to gestational diabetes mellitus, maternal obesity/overweight fetal overgrowth. The purpose of present study is investigate correlation between First FPG lipid concentrations, their potential association with offspring size delivery. Pregnant women that received regular care delivered in our center 2013 were recruited for study. Fasting tested prior delivery (Before Delivery...
Objective Primary biliary cholangitis (PBC) is an autoimmune disease with significant gender difference. X chromosome inactivation (XCI) plays important roles in susceptibility to diseases between genders. This work focuses on the differences of LncRNA XIST several defined immune cells populations as well its effects naive CD4+ T proliferation and differentiation patients PBC. Methods NKs, B cells, T, CD8+ were separated by MicroBeads from peripheral blood mononuclear (PBMCs) PBC healthy...
Abstract Background The prevalence of both placenta previa and cesarean are on the rise. Multiple adverse outcomes critically increased when is subsequent to prior cesarean. purpose present study develop a pre-surgical method for predicting in pregnancy complicated with Methods Clinical data was obtained from medical history system at First Affiliated Hospital Sun Yat-sen University February 2003 December 2016. All cases final diagnosis “placenta previa/low lying (ICD:O44.001-105)” “scarred...
Abstract Aim The aim of the present study was to investigate maternal and umbilical cord serum dipeptidyl peptidase IV (DPP4) concentrations in women with without gestational diabetes mellitus (GDM), evaluate a potential correlation between neonatal anthropometry DPP4 concentration. Methods Twenty‐eight GDM 25 normal glucose tolerance (NGT) pregnant were recruited into study. Maternal measured by enzyme immunoassay. clinical data, glucose, insulin, triglyceride, cholesterol, high‐density...
Abstract Background Gestational diabetes mellitus (GDM) prevalence is on the rise globally. Offspring of diabetic mothers face increased risk neonatal hypoglycaemia (NH), and women with GDM have abnormal lipid profiles. However, there no consensus link between maternal blood lipids NH in infants from GDM. This study aimed to explore how affect NH. Methods A retrospective cohort was conducted at First Affiliated Hospital Sun Yat-sen University. Information participants’ baseline...
Abstract Background History of gestational diabetes mellitus (GDM) and serum lipid abnormalities were associated with postpartum impaired glucose tolerance . To investigate the association between concentration total cholesterol (TC), at time GDM diagnosis, risk intolerance. Methods Women who diagnosed a live singleton delivery January 1, 2013 December 31, 2017 included. grouped based on TC quartiles diagnosis had an OGTT 6–12 weeks after delivery. The relationship intolerance was assessed...
Abstract Aim: To investigate the relationship between maternal overweight and fetal insulin resistance. Material Methods: Nineteen 30 lean pregnant women were recruited in present study. Maternal resistance determined by measuring sex hormone binding globulin (SHBG) concentrations venous or umbilical cord serum, respectively. age, gestational height, pre‐gravidity weight, pre‐partum as well gender, birth head circumference collected clinical data. Results: Fetuses of mothers had larger...
Abstract Introduction: Attaining lung isolation in the infant is a challenge for anesthesia care providers. Pulmonary lobe more challenging. We describe an approach to performing selective pulmonary using pediatric endobronchial blocker absence of appropriate auxiliary guidance tool. Patient concerns: An 8-month-old and 9.5 kg male was admitted because repeated cough with fever 3 months large cyst his right 2 weeks. He had been living pastoral area parents. Diagnosis: Based on chest computed...
Abstract Objective: To investigate thyroid-stimulating hormone (TSH) levels and thyroid peroxidase antibody (TPOAb) in early pregnancy to estimate the risk of development gestational diabetes mellitus (GDM). Methods: The TSH, free thyroxine, triiodothyronine, TPOAb were retrospectively evaluated 2333 pregnant women. All women recruited divided into groups TSH high (H), low (L), (H) positive (+), (H)TPOAb negative (−), normal (N)TPOAb (L)TPOAb estimated GDM. Results: level ( X 2 = 13.0024, P...
Introduction: While premature ventricular contractions (PVCs) are generally considered benign, recent evidence suggests that even the preceding PVCs inefficient so a moderate burden of may be associated with loss contractile efficiency and increased risk events. It is however unclear what proportion stable heart failure (HF) patients have to high PVCs, despite being well-treated. Aim: The aim this study was assess HF more than 5% whether higher number related worse outcomes. Methods: We...