A5102800501- Tracheal and airway disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Vascular Anomalies and Treatments
- Retinoids in leukemia and cellular processes
- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- Esophageal and GI Pathology
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Airway Management and Intubation Techniques
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Circular RNAs in diseases
- Liver Disease and Transplantation
- MicroRNA in disease regulation
- Metabolism, Diabetes, and Cancer
- Lung Cancer Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Sirtuins and Resveratrol in Medicine
- Cancer Immunotherapy and Biomarkers
- Medical Imaging and Pathology Studies
First Affiliated Hospital of Zhengzhou University
2016-2025
Zhengzhou University
2014-2025
Weatherford College
2020
Huazhong University of Science and Technology
2009-2010
miR-199a-3p was significantly downregulated in the majority of human hepatocellular carcinoma (HCC) tissues and HCC cell lines. Yes associated protein 1 (YAP1) overexpressed HCC, which promoted development progression by upregulating Jagged1 activating Notch pathway. We searched potential targets with DIANA, TargetScan PicTar tools, found that YAP1 is one targets. Based on these findings, we speculated might suppress growth targeting YAP1, downregulating suppressing determined expression...
Microwave ablation (MWA) has been widely used in the treatment of solid tumors. Studies have less conducted on efficacy MWA with cell immunotherapy treating hepatocellular carcinoma (HCC). The current study aimed at exploring combination HCC. Hepa1-6 HCC mice were treated by MWA, blockade, or combined therapy (MWA blockade), left untreated. Survival rates plotted Kaplan-Meier Curve, followed log-rank test. 25 days after operation, surviving monitored for tumor recurrence, and volumes...
This study was carried out to investigate the effects of resveratrol on cigarette smoke (CS)-induced lung injury. Experimental mice were administrated with 1 mg/kg or 3 mg/ kg orally, h prior CS exposure (five cigarettes a day for consecutive days). Airway inflammation and gene expression changes assessed. increased number pulmonary inflammatory cells, coupled elevated production tumor necrosis factor α interleukin-6 in bronchoalveolar lavage fluids. Resveratrol treatment decreased...
The tumor microenvironment orchestrates the sustained growth, metastasis and recurrence of cancer. As an indispensable component microenvironment, cancer‐associated fibroblasts (CAF) are considered as essential synthetic machine producing various components, leading to cancer stemness, drug resistance recurrence. Here, we developed a sustainable primary culture lung cells fed with fibroblasts, resulting in enrichment acquisition cells. Moreover, IGF2/AKT/Sox2/ABCB1 signaling activation was...
Excessive vascularization during tracheal in-stent restenosis (TISR) is a significant but frequently overlooked issue. We developed an anti-inflammatory coupled anti-angiogenic airway stent (PAGL) incorporating anlotinib hydrochloride and silver nanoparticles using advanced electrospinning technology. PAGL exhibited hydrophobic surface properties, exceptional mechanical strength, appropriate drug-release kinetics. Moreover, it demonstrated remarkable eradication effect against...
Esophageal carcinoma is a frequently occurring cancer at upper gastrointestinal tract. We aimed to evaluate the roles and possible mechanism of Runt Related Transcription Factor 2 (RUNX2) in development esophageal cancer.The expression RUNX2 tissues cells was investigated by qRT-PCR. Effects on cell viability, apoptosis, migration invasion were assessed using MTT assay, flow cytometry assay/western blot analysis, Transwell assays, respectively. Afterwards, effects activation PI3K/AKT ERK...
Abstract This randomized, prospective, multicenter (12 centers in China) phase III trial (Chinese Clinical Trial Registry #ChiCTR2000041170) compared drug-eluting bead transarterial chemoembolization (DEB-TACE) combined with apatinib and DEB-TACE monotherapy for patients unresectable hepatocellular carcinoma (uHCC). Progression-free survival (PFS) was the primary endpoint. Overall (OS), mRECIST-based objective response rates (ORR) disease control (DCR), treatment-related adverse events...
To investigate the association between overt hepatic encephalopathy (OHE) and liver pathology after transjugular intrahepatic portosystemic shunt (TIPS) creation in cirrhotic patients. From July 2015 to April 2024, 73 patients from 4 hospitals China who received TIPS biopsy were retrospectively enrolled this study. Based on whether OHE occurred within 3 months creation, categorized into (n = 29) non-OHE 44) groups. The was assessed by hematoxylin-eosin (H&E), Sirius red staining,...
A 48-year-old man visited our department with a 3-month history of intermediate abdominal pain. In the past 2 months, he had received two cycles chemotherapy for gastric T-cell lymphoma colon invasion. Seven days ago, suffered diarrhea food debris after liquid diet. Abdominal computed tomography (CT), gastrointestinal radiography, and gastroscopy revealed formation gastrocolonic fistula transverse colonic stenosis ([Fig. 1]). Colonic stenting plus vascular plug placement was developed to...
<title>Abstract</title> COLEC10 and COLEC11 are soluble members of collectin super family. presumed to act as pattern recognition receptors activate the complement system via binding MASP1. A recent study has demonstrated that is predominantly produced by hepatic stellate cells involved in pathogenesis liver fibrosis, which indicates function beyond receptors. However, it not clear whether serum concentrations can be diagnostic markers chronic disease (CLD). Therefore, we designed a...
Circular RNA (circRNA) has been proved to play a vital role in atherosclerosis (AS) progression, and vascular smooth muscle cells (VSMCs) are involved the progression of AS. However, in-depth mechanism by which circRNA regulates VSMC proliferation migration remains be elusive.We used tumor necrosis factor-alpha (TNF-α) treat VSMCs establish cell model We Cell Counting Kit-8, terminal-deoxynucleoitidyl transferase-mediated nick end labeling, transwell assays assess proliferation, apoptosis,...
Abstract Stent-related granulation tissue hyperplasia is a major complication that limits the application of stents in airways. In this study, an arsenic trioxide-eluting electrospun nanofiber-covered self-expandable metallic stent (ATO-NFCS) was developed. Poly-L-lactide-caprolactone (PLCL) selected as drug-carrying polymer. Stents with two different ATO contents (0.4% ATO/PLCL and 1.2% ATO/PLCL) were fabricated. The vitro release simulated airway fluid suggested total time 1 d. growth...
This study aimed to investigate whether liposomal quercetin (LQ) could enhance the effects of microwave ablation (MVA) in treating rabbit VX2 liver tumor model.Rabbits with tumors were randomly divided into three groups: intravenous LQ group (LQ group), MWA and combined + MWA) group. Five rabbits selected sacrificed from each at 12 h on days 3, 7 14 operation. The samples detected quantified by immunohistochemistry, Western blot, reverse transcription polymerase chain reaction (RT-PCR).For...
High concentrations of arsenic trioxide (As2O3) are used to treat acute promyelocytic leukemia and solid tumors, with negative side effects normal cells. Andrographolide is a traditional Chinese medicine that exerts anti-cancer, anti-inflammatory, anti-virus, anti-diabetic effects. Here, we tested the combined andrographolide As2O3 against hepatocellular carcinoma (HCC). We found by increasing apoptosis, synergistically enhanced anti-tumor in HepG2 cells vitro vivo. Furthermore, results from...
Background Metastasis to the adrenal glands is frequent in patients with various cancers and gland biopsy routinely performed using ultrasound or computed tomographic (CT) guidance. However, this method technically challenging, especially case of small masses. Purpose To determine whether new real-time stereotactic needle guidance technique C-arm cone-beam CT (CBCT) allows safe accurate masses, those hard-to-reach anatomical locations. Material Methods CBCT was used perform 60 procedures...
Abstract It has been reported that CagA of Helicobacter pylori reduced PTEN expression by enhancing its promoter methylation. Furthermore, diabetes mellitus (DM) may also promote the methylation status PTEN, a tumour suppressor gene in gastric cancer (GC). is intriguing to explore whether DM strengthen tumorigenic effect H (HP) promoting and administration metformin reduce risk GC suppressing promoter. In this study, we enrolled 107 patients grouped them as HP(−)DM(−) group, HP(+)DM(−) group...
Background &amp; aims This multicenter retrospective study evaluated the efficacy and safety of transarterial chemoembolization (TACE) combined with donafenib a programmed death-1 (PD-1) inhibitor (TACE+DP) TACE (TACE+D) for unresectable hepatocellular carcinoma (uHCC). Methods The clinical data 388 patients uHCC who received TACE+DP or TACE+D as first-line treatment at six Chinese academic centers from July 2021 to 2022 were collected analyzed retrospectively. Patients in group an...
Nowadays, flat detector (FD) equipped angiographic C-arm computed tomography (CACT) systems can be used to acquire CT-like cross-sectional images directly within the interventional suite. The CACT offer real time visualization of transthoracic needle biopsy (TNB) procedure and more flexibility in orientation system around patient compared traditional CT systems.To evaluate value a CT-guidance performing percutaneous (PTNB) for small (≤3 cm) pulmonary lesions clinical practice.A total 60...