A5043864643- Wound Healing and Treatments
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Liver physiology and pathology
- Periodontal Regeneration and Treatments
- Dermatologic Treatments and Research
- Sleep and Wakefulness Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- RNA Research and Splicing
- Burn Injury Management and Outcomes
- Tendon Structure and Treatment
- Tribology and Lubrication Engineering
- Tea Polyphenols and Effects
- Pancreatic function and diabetes
- Phytochemicals and Antioxidant Activities
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gear and Bearing Dynamics Analysis
- Lubricants and Their Additives
- Hydraulic and Pneumatic Systems
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Dam Engineering and Safety
- Microbial Natural Products and Biosynthesis
- Pressure Ulcer Prevention and Management
Changchun University
2020-2024
Tsinghua University
2023-2024
First Affiliated Hospital of Zhengzhou University
2021-2023
Lanzhou University
2023
East China University of Technology
2023
China University of Geosciences (Beijing)
2023
China National Petroleum Corporation (China)
2023
China National Offshore Oil Corporation (China)
2023
Institute of Special Animal and Plant Sciences
2017-2022
Chinese Academy of Agricultural Sciences
2017-2022
Abstract Background Scar formation is a common consequence of skin wound healing, and no effective treatment exists. Umbilical cord blood mesenchymal stem cells (UCB-MSCs) can improve healing; however, the role UCB-MSCs remains unclear whether they ameliorate scar has not been fully elucidated. Methods To determine function UCB-MSCs, we examined compared therapeutic effects UCB-MSC-derived exosomes (UCB-MSC-exo) on healing in rats. Moreover, UCB-MSC-exo-specific miRNAs were identified their...
The annual regrowth of deer antlers provides a valuable model for studying organ regeneration in mammals. We describe single-cell atlas antler regrowth. earliest-stage initiators were mesenchymal cells that express the paired related homeobox 1 gene ( PRRX1 + cells). also identified population “antler blastema progenitor cells” (ABPCs) developed from and directed process. Cross-species comparisons ABPCs several mammalian blastema. In vivo vitro displayed strong self-renewal ability could...
Abstract Background Scar formation, which may be caused by myofibroblast aggregations, is the greatest challenge during skin wound healing in clinical setting. Studies have indicated that epidermal stem cells (EPSC) improve and reduce scar formation. Methods We investigated therapeutic effects of EPSC-derived exosomes (EPSC-Exos) on a skin-defect rat model. also examined roles EPSC-Exos-specific microRNAs inhibiting differentiation human dermal fibroblasts (HDF) into myofibroblasts. Results...
Adult wound healing often results in fibrotic scarring that is caused by myofibroblast aggregation. Human amniotic fluid stem cells (hAFSCs) exhibit significantly anti-fibrotic properties during healing. However, it little known whether hAFSCs directly or indirectly (paracrine) contribute to this process. Using the full-thickness skin-wounded rats, we investigated therapeutic potential of hAFSC-derived exosomes (hAFSC-exo). Our showed hAFSC-exo accelerated rate and improved regeneration hair...
Deer antlers are the only mammalian appendages that can fully regenerate from periosteum of pedicles (PP). This regeneration process starts regenerative healing wounds. Removal PP abolishes antler regeneration, however, cutaneous wound proceeds, indicating some factors in circulation contribute to this healing. In study, we produced a scalp deer either period (ARP) (n = 3) or non-ARP 3). Results showed full took place when was created during ARP. Interestingly, topical application systemic...
Regeneration is the preferred approach to restore structure and function after tissue damage. Rapid proliferation of cells over site damage integral process regeneration. However, even subtle mutations in proliferating may cause detrimental effects by eliciting abnormal differentiation. Interestingly deer antlers, arguably fastest regenerating mammalian tissue, have not been reported, thus far, grow malignant tumors. They provide a model understand possible mechanism which rapid regeneration...
Aging is the greatest risk factor for most neurodegenerative diseases, which associated with decreasing cognitive function and significantly affecting life quality in elderly. Computational analysis suggested that 4 anthocyanins from chokeberry fruit increased Klotho (aging-suppressor) structural stability, so we hypothesized could antiaging. To explore effects of treatment on brain aging, mice treated 15 or 30 mg/kg by gavage injected D-galactose accelerated aging per day. After 8 weeks,...
Abstract Background When the deer antler is cast, it leaves a cutaneous wound that can achieve scarless healing due to presence of stem cells (ASCs). This provides an opportunity study regenerative healing. Methods In this study, we investigated therapeutic effects and mechanism cell-conditioned medium (ASC-CM) on in rats. vitro, ASC-CM proliferation HUVEC NIH-3T3 cell lines. vivo, evaluated using full-thickness skin punch-cut wounds Results The results showed significantly stimulated vitro....
Male infertility is a global issue that seriously affects reproductive health. This study aimed to understand the underlying causes of idiopathic non-obstructive azoospermia (iNOA), which type male with unknown origins accounts for 10-15% cases. By using single-cell analysis techniques, we uncover mechanisms iNOA and gain insight into cellular molecular changes in testicular environment. In this study, performed bioinformatics scRNA-seq microarray data obtained from GEO database. The...
Background: Type 1 diabetes mellitus (T1D) represents a severe threat to human health. Persistent hyperglycemia and dyslipidemia can lead damaged liver function, while effective interventions for these complications are currently lacking. Deer antler stem cells (AnSCs), novel type of adult cells, significantly reduced injury, which was speculated be achieved through the paracrine pathway. Methods: In this study, AnSC-conditioned medium (AnSC-CM) used treat C57BL/6 mice with T1D symptoms...
Background Sleep fragmentation is a persistent problem throughout the course of Parkinson’s disease (PD). However, related neurophysiological patterns and underlying mechanisms remained unclear. Method We recorded subthalamic nucleus (STN) local field potentials (LFPs) using deep brain stimulation (DBS) with real-time wireless recording capacity from 13 patients PD undergoing one-night polysomnography recording, 1 month after DBS surgery before initial programming when were off-medication....
Abstract Background Pulmonary fibrosis (PF), the end point of interstitial lung diseases, is characterized by myofibroblast over differentiation and excessive extracellular matrix accumulation, leading to progressive organ dysfunction usually a terminal outcome. Studies have shown that umbilical cord-derived mesenchymal stromal cells (uMSCs) could alleviate PF; however, underlying mechanism remains be elucidated. Methods The therapeutic effects uMSC-derived vesicles (uMSC-EVs) on PF were...
Introduction: Skin wounds generally heal by scarring, a fibrotic process mediated the Engrailed-1 (EN1) fibroblast lineage. Scar is detrimental to tissue structure and function, but perfect healing in clinical settings remains be explored. Recent studies have shown that mesenchymal stem cell (MSC) transplantation can reduce scarring Methods: Here, we investigated effects of placental MSCs (pMSCs) exosomes derived from pMSCs (pMSC-exos) on wound using full-thickness rat model. Results: The...
The typical outcome of mammalian wound healing is scarring, a fibrotic process mediated by myofibroblast aggregation. Perfect in clinical setting relatively unexplored. Surprisingly, our previous studies have shown that the large (10 cm diameter or more) pedicle deer naturally achieves regenerative restoration, realized through paracrine pathway from adjacent antler stem cells (AnSCs).AnSC-derived exosomes (AnSC-exos) were topically injected around full-thickness wounds rat model. effects on...
Given the current research gap regarding cavitation phenomena and startup conditions in water-lubricated bearings (WLBs), this study offers an innovative approach by integrating mass conservation boundary condition proposed Jakobsson, Floberg, Olsson (known as JFO condition) with a transient mixed lubrication model of WLBs. It also considers impact elastic deformation surface roughness peaks, thus establishing WLBs that incorporates effect. Furthermore, dynamic behaviors are contrasted...
Radiation-induced cutaneous injury is the main side effect of radiotherapy. The difficult to cure and pathogenesis complex. Mesenchymal stem cells (MSCs) serve as a promising candidate for cell-based therapy treatment wounds. aim present study was investigate whether antler (AnSCs) have better therapeutic effects on radiation-induced than currently available ones. In this study, rat model wound from Sr-90 radiation used. AnSCs (1 × 10 6 /500 μl) were injected through tail vein first day...
Aim Scar formation generally occurs in cutaneous wound healing mammals, mainly caused by myofibroblast aggregations, and currently with few effective treatment options. However, the pedicle (about 10 cm diameter) of deer can initiate regenerative healing, which has been found to be achieved via paracrine factors from internal tissues antlers. Methods Enzymatically digested velvet antler peptides (EVAP) were prepared along other types extracts as controls. The effects EVAP on full-thickness...
Liver fibrosis results from collagen fiber deposition. Antler stem cells (ASCs) naturally in vivo differentiate into cartilage, which is only made of Col II component; whereas liver caused by over-abundance I and III. In addition, ASCs can effectively promote regenerative wound healing tissue contains very few fibers (Col I). this study, we investigate the therapeutic effects a rat model CCl4-induced fibrosis. Rats were treated with for 4 weeks vivo, then biochemical histopathological...
Sea buckthorn ( Hippophae rhamnoides L.) is a berry bearing multiple nutritional properties. In this study, 46 compounds were isolated from sea berries. Preliminary data showed that the components, C13, C15, and C32, exhibited profound inhibitory effect on activation of hepatic stellate cells (HSCs) induced by transforming growth factor-β (TGF-β) decreased levels inflammatory factors. Furthermore, these over-regulated proteins DNA damage signaling pathway alpha-smooth muscle actin (α-SMA)....
Phytochemicals from lingonberry have rich pharmacological value and may play an essential role in treating liver diseases. We investigated the regulatory of anthocyanins (LA) on HSC activation vitro fibrogenesis vivo. The viability HSCs treated with LA was significantly reduced a dose-dependent manner at concentration 25-100 μg/mL, which monomers also proliferation via IC50 assay. inducer transforming growth factor β1 (TGFβ1) effector α-smooth muscle actin (α-SMA) were all decreased both...
Deer antlers constitute a unique mammalian model for the study of both organ formation in postnatal life and annual full regeneration. Previous studies revealed that these events are achieved through proliferation differentiation antlerogenic periosteum (AP) cells pedicle (PP) cells, respectively. As resident AP PP possess stem cell attributes, antler generation regeneration cell-based processes. However, composition each tissue type molecular underlying development remain poorly...