A5056688127- Hepatocellular Carcinoma Treatment and Prognosis
- Tracheal and airway disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Liver Disease Diagnosis and Treatment
- Vascular Anomalies and Treatments
- Liver Disease and Transplantation
- Pancreatic and Hepatic Oncology Research
- MRI in cancer diagnosis
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Gallbladder and Bile Duct Disorders
- Peptidase Inhibition and Analysis
- Nanoplatforms for cancer theranostics
- Electrospun Nanofibers in Biomedical Applications
- Esophageal and GI Pathology
- Cancer Immunotherapy and Biomarkers
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal Cancer Research and Treatment
- Maternal and fetal healthcare
- Pregnancy and preeclampsia studies
- Cancer, Hypoxia, and Metabolism
- Head and Neck Surgical Oncology
First Affiliated Hospital of Zhengzhou University
2019-2023
Southeast University
2023
Zhongda Hospital Southeast University
2023
Zentrallaboratorium Deutscher Apotheker
2021
Centre Hospitalier de Niort
2021
Zhengzhou University
2020-2021
Chengdu University of Traditional Chinese Medicine
2021
Weatherford College
2021
Southwest Medical University
2020
Background : Esophageal adenocarcinoma (EAC) remains a leading cause of cancer-related deaths worldwide and demonstrates predominant rising incidence in Western countries. Recently, immunotherapy has dramatically changed the landscape treatment for many advanced cancers, with benefit EAC thus far been limited to small fraction patients. Methods Using somatic mutation data The Cancer Genome Atlas (TCGA) International Consortium, we delineated patients from US England. Based on expression TCGA...
Anti-inflammatory and antihyperplasia activities are essential requirements for the successful use of airway stents. In this work, silver nanoparticles (AgNPs) cisplatin (DDP) were combined in a synergistic modification strategy to improve surface function Using polycaprolactone (PCL) as drug carrier, dual-functional PCL-AgNPs-DDP fiber film-coated stent was fabricated by electrospinning. The physicochemical biological properties obtained films examined. ATR-FTIR, XPS, SEM-EDS TEM results...
Abstract As essential regulators of gene expression, miRNAs are engaged in the initiation and progression colorectal cancer (CRC), including antitumour immune response. In this study, we proposed an integrated algorithm, ImmuMiRNA, for identifying miRNA modulators immune‐associated pathways. Based on these miRNAs, applied LASSO algorithm to develop a reliable individualized signature evaluating overall survival (OS) inflammatory landscape CRC patients. An external public data set qRT‐PCR...
Antibacterial and antihyperplasia airway stents are highly desirable for tracheal stenosis. Herein, a series of polylactic acid (PLA) silver nanoparticles (AgNPs) nanofiber membranes (PLA, PLA-4 %AgNPs PLA-6 % AgNPs) were prepared by electrospinning. The physicochemical biological properties the resultant examined. SEM drug release results indicated that AgNPs successfully introduced into PLA, could be sustained to released from membranes. showed antibacterial activity against S. aureus P....
Hypoxia is a universal feature in the tumor microenvironment (TME). Nonetheless, heterogeneous hypoxia patterns of TME have still not been elucidated hepatocellular carcinoma (HCC). Using consensus clustering algorithm and public datasets, we identified subtypes. We also revealed specific biological clinical characteristics via bioinformatic methods. The principal component analysis was employed to develop hypoxia-associated risk score (HARS). two subtypes: low pattern (C1) high (C2). C1...
Abstract Purpose To evaluate the method and effectiveness of transcatheter arterial chemoembolization (TACE) combined with simultaneous DynaCT-guided Microwave ablation (MWA) for treatment small hepatocellular carcinoma (SHCC). Materials methods From June 2015 to May 2017, a total 28 consecutive patients SHCC received single TACE 23 subjects combination MWA. Following 1 month treatment, tumor response was assessed using mRECIST criteria outcomes were analyzed including...
The goal of this study was to determine the clinical efficacy and safety drug-eluting bead (DEB) transarterial chemoembolization (TACE) in combination with apatinib administration patients advanced hepatocellular carcinoma (HCC).From December 2015 May 2017, a total 32 HCC treated DEB-TACE combined were consecutively enrolled study. treatment response laboratory outcomes assessed at first- third month after therapy. Overall survival, progression-free adverse events also analyzed assessed.The...
Abstract Background Given their widespread availability and relatively low cost, percutaneous thermal ablation is commonly performed under the guidance of computed tomography (CT) or ultrasound (US). However, such imaging modalities may be restricted due to insufficient image contrast limited tumor visibility, which results in imperfect intraoperative treatment an increased risk damage critical anatomical structures. Currently, magnetic resonance (MR) has been proven a possible solution...
Abstract Stent-related granulation tissue hyperplasia is a major complication that limits the application of stents in airways. In this study, an arsenic trioxide-eluting electrospun nanofiber-covered self-expandable metallic stent (ATO-NFCS) was developed. Poly-L-lactide-caprolactone (PLCL) selected as drug-carrying polymer. Stents with two different ATO contents (0.4% ATO/PLCL and 1.2% ATO/PLCL) were fabricated. The vitro release simulated airway fluid suggested total time 1 d. growth...
Site-specific release of therapeutics at the infected trachea remains a great challenge in clinic. This work aimed to develop series vancomycin (VA)-loaded polycaprolactone (PCL) composite nanofiber films (PVNF-n, n = 0, 1, and 5, respectively) via electrospinning technique. The physiochemical biological properties PVNF-n were evaluated by tests, such as FT-IR, XRD, SEM-EDS, antibacterial assay. samples displayed typical network structure fibers with random directions. VA was successfully...
Idiopathic pulmonary fibrosis (IPF) is a highly fatal lung disease of unknown etiology with median survival after diagnosis only 2-3 years. Its poor prognosis due to the limited therapy options available as well lack effective prognostic indicators. This study aimed construct novel signature for IPF assist in personalized management patients during treatment.Differentially-expressed genes (DEGs) versus healthy individuals were analyzed using "limma" package R software. Immune-related (IRGs)...
Accumulating evidence has demonstrated that microRNAs (miRNAs or miRs) play an important role in the diagnosis and prognosis of tumors. In case cholangiocarcinoma (CCA), miRNAs may serve as potential tumor biomarkers therapeutic targets. Based on The Cancer Genome Atlas (TCGA) database, fold change >2 was used to screen out with differential expression patients CCA. Univariate multivariate Cox regression analyses identified miR-3913-5p independent prognostic factor Overall survival...
Advanced glycation end products (AGEs) have been widely regarded as an important inducing factor in the pathogenesis of diabetic arteriosclerosis, and proliferation migration vascular smooth muscle cells (VSMCs) are also involved this process. However, it is not clear whether AGEs promote atherosclerosis by VSMCs. To figure out question, study investigated effects on human aorta (HASMCs) underlying mechanisms. This evaluated different concentrations cell migration. CCK8, transwell, western...
Transcatheter arterial embolization (TAE) is one of the first-line treatments for advanced hepatocellular cancer. The pain caused by TAE a stark complication, which remains to be prevented biomedical engineering methods.Herein, commercial embolic agent CalliSpheres® bead (CB) was functionally modified with lidocaine (Lid) using an electrostatic self-assembly technique. products were coded as CB/Lid-n (n = 0, 5, 10, corresponding relative content Lid). chemical compositions, morphology,...
Abstract Background Fractured catheter as a foreign body in situ is rare complication after port placement. We report single center’s experience on percutaneous transvenous retrieval of intravascular fractured and treatment techniques. Methods Patients undergoing from Jan 2010 to Dec 2018 were retrospectively collected. A total 10 patients (8 females 2 males) enrolled this study. Procedures performed within 1 day diagnosis. Two methods considered, direct by gooseneck snare guide wire media...
Background. Hepatocellular carcinoma (HCC) remains an important cause of cancer death. The molecular mechanism hepatocarcinogenesis and prognostic factors HCC have not been completely uncovered. Methods. In this study, we screened out differentially expressed lncRNAs (DE lncRNAs), miRNAs miRNAs), mRNAs mRNAs) by comparing the gene expression normal tissue in Cancer Genome Atlas (TCGA) database. DE were used to perform Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG) pathway...
Abstract Background: Increasing evidence has indicated immune-related genes (IRGs) play a key role in the development of hepatocellular carcinoma (HCC). Whereas, there have been no investigations proposing reliable prognostic signature terms IRGs. This study aimed to develop robust based on IRGs HCC. A total 597 HCC patients from The Cancer Genome Atlas (TCGA) and International Consortium (ICGC) databases were enrolled this study. Methods: TCGA cohort was utilized for discovery, ICGC...