A5071504290- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Musculoskeletal pain and rehabilitation
- Hernia repair and management
- Colorectal Cancer Surgical Treatments
- Autoimmune and Inflammatory Disorders Research
- Gastrointestinal motility and disorders
- Histiocytic Disorders and Treatments
- Immune Cell Function and Interaction
- Diverticular Disease and Complications
- Parvovirus B19 Infection Studies
- Lymphoma Diagnosis and Treatment
- Myofascial pain diagnosis and treatment
- Stoma care and complications
- Pressure Ulcer Prevention and Management
- Acute Lymphoblastic Leukemia research
- Pelvic and Acetabular Injuries
- Cardiac, Anesthesia and Surgical Outcomes
- Viral-associated cancers and disorders
- Glaucoma and retinal disorders
- Urinary Bladder and Prostate Research
- Congenital gastrointestinal and neural anomalies
- Immunodeficiency and Autoimmune Disorders
- Heat shock proteins research
- Enhanced Recovery After Surgery
Phoenix Children's Hospital
2010-2025
Center for Cancer and Blood Disorders
2010-2025
University of Arizona
2018-2023
Henry M. Jackson Foundation
2023
Uniformed Services University of the Health Sciences
2023
University of Illinois Chicago
2021-2022
Loyola Medicine
2021
University of Illinois Hospital & Health Sciences System
2021
Edward Hines, Jr. VA Hospital
2019
Loyola University Medical Center
2019
Abstract We have studied the pelvic floor musculature and its innervation in 14 of 24 (58 per cent) multiparous women who had been recruited into a study effect childbirth on as part prospective investigation that began 1983. These all delivered by vaginal route without forceps assistance. Five developed clinical symptoms stress incontinence 5 years later; two them further uncomplicated delivery during this time. There was manometric neurophysiological evidence weakness because partial...
Primary hemophagocytic lymphohistiocytosis is a rare syndrome characterized by immune dysregulation and hyperinflammation. It typically manifests in infancy associated with high mortality.We investigated the efficacy safety of emapalumab (a human anti-interferon-γ antibody), administered dexamethasone, an open-label, single-group, phase 2-3 study involving patients who had received conventional therapy before enrollment (previously treated patients) previously untreated were 18 years age or...
We have studied 20 patients with the descending perineum syndrome, half of whom were incontinent faeces. Objective criteria established in 103 control subjects for determining relationship to bony pelvis. The anal reflex latency was increased 10 perineal descent associated faecal incontinence, but not without incontinence. However, there hypertrophy muscle fibers external sphincter biopsies all patients. Thus, abnormal degrees are changes muscle, consistent damage its nerve supply.
Abstract ALK-positive histiocytosis is a rare subtype of histiocytic neoplasm first described in 2008 3 infants with multisystemic disease involving the liver and hematopoietic system. This entity has subsequently been documented case reports series to occupy wider clinicopathologic spectrum recurrent KIF5B-ALK fusions. The full molecular spectra remain, however, poorly characterized. Here, we describe largest study date, detailed data 39 cases, including 37 cases confirmed ALK...
To investigate the aetiological importance of bowel dysfunction in patients with uterovaginal prolapse and urinary stress incontinence.Observational study using a questionnaire about obstetric history function, anorectal physiological studies.Physiology unit gynaecological outpatients departments two teaching hospitals.Twenty-three women (mean age 57 years), 23 incontinence 52 years) 27 control years).There was no statistically significant difference between three groups their parity, or...
Osteosarcoma is the most common malignant bone tumor in children. patients who respond poorly to chemotherapy are at a higher risk of relapse and adverse outcome. Therefore, it was aim this study identify prognostic factors time diagnosis characterize genes predictive poor survival outcome potential novel therapeutic targets. Expression profiling 30 osteosarcoma diagnostic biopsy samples, 15 with inferior necrosis following induction (Huvos I/II) superior III/IV), conducted using Affymetrix...
Paradoxical contraction of the puborectalis muscle during simulated defecation straining (anismus) has been cited as a cause constipation. The functional specificity this phenomenon was evaluated in 79 patients, 50 with constipation, 21 idiopathic perineal pain, and eight solitary rectal ulcer syndrome. Electromyogram evidence paradoxical observed 38 (76 percent), ten (48 four (50 percent) these respectively. All patients syndrome had difficulty defecating; normal all pain. These...
Summary. The commonest cause of external anal sphincter division is injury during childbirth. We have studied 20 patients with anterior using physical and electrophysiological techniques. There was evidence pudendal nerve damage in 60% these patients. This finding suggests that to the innervation often co‐exists direct muscle; pelvic floor surgery may be required, addition repair itself.
Abstract Ninety-one healthy subjects (51 women; age range 16–85 years) were studied prospectively to determine the effect of age, sex and parity on anorectal function. Maximum resting pressure, voluntary contraction rectal sensation distension, mid-anal electrosensitivity, perineal descent, pudendal nerve terminal motor latency fibre density external anal sphincter measured. Sex influenced mean(s.d.) pressure (148(56) versus 95(43) cmH2O for men women, P<0·0001), descent straining...
Abstract In some patients with faecal incontinence due to an obstetric tear of the external anal sphincter there is additional weakness muscles from damage innervation these during delivery. Of 19 who required surgical repair months or years after injury, 9 (47 per cent) had evidence pudendal nerve at pre-operative anorectal physiological investigation. The result was excellent good in eight ten whom no damage, while this case only one nine damage. These results are significantly different...
Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening, hyperinflammatory syndrome. Emapalumab, fully human monoclonal antibody that neutralizes the proinflammatory cytokine interferon gamma, approved in United States to treat primary HLH (pHLH) patients with refractory, recurrent, or progressive disease, intolerance conventional treatments. REAL-HLH, retrospective study, conducted across 33 US hospitals, evaluated real-world treatment patterns and outcomes treated ≥1 dose of...
Abstract The relationship between perineal descent and pudendal nerve damage was tested in 57 consecutive patients by measuring the left right terminal motor latency (PNTML) before after a maximal defaecation straining effort. In 13 PNTML also measured 1 4 min later. difference mean (ΔPNTML) correlated with amount of (r = 0.40, P<0.005), position during −0.46, P<0.001). Four minutes effort again approached resting value each subject. These findings support concept that causes damage.
The innervation of the puborectalis and external anal sphincter muscles was studied in 32 patients with idiopathic (neurogenic) faecal incontinence, 12 whom also had complete rectal prolapse, using transcutaneous spinal stimulation, transrectal pudendal nerve single fibre EMG, anorectal manometry, measurement perineal descent. Fourteen normal subjects served as controls. Significant increases motor latencies from L1 to were shown all incontinent (p less than 0.01). (EMG) density increased...
Intraluminal pressure activity has been recorded in the unprepared true sigmoid colon of seven normal controls (mean age 37 years, range 22-55, three men) and patients with irritable bowel syndrome (IBS) (45 24-75, four for 30 minutes before 100 after a standard 1000 kcal meal. Results differ from previously published data by showing much higher indices amplitudes up to 490 mmHg IBS, 450 controls. Study segment index mean wave were significantly (p less than 0.015 p 0.01) IBS controls, but...
Journal Article Risk factors in childbirth causing damage to the pelvic floor innervation Get access S J Snooks, Snooks Sir Alan Parks Physiology Unit, St. Mark's Hospital, City Road, London EC1V2PS, UKDepartment of Obstetrics, Bartholomew's EC1A 7BE, UK Search for other works by this author on: Oxford Academic Google Scholar M Swash, Swash Henry, Henry Setchell British Surgery, Volume 72, Issue Supplement_1, September 1985, Pages s15–s17, https://doi.org/10.1002/bjs.1800721311 Published: 08...
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare cancer, and large international cooperative efforts are needed to evaluate the significance of clinical risk factors immunoarchitectural patterns (IAPs) for all stages pediatric adult patients with NLPHL.