A5013427733- Platelet Disorders and Treatments
- Trauma and Emergency Care Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood groups and transfusion
- Musculoskeletal pain and rehabilitation
- Blood transfusion and management
- Blood properties and coagulation
- Liver Disease and Transplantation
- Bone fractures and treatments
- Hip and Femur Fractures
- Liver Disease Diagnosis and Treatment
- Complement system in diseases
- Hemophilia Treatment and Research
- Opioid Use Disorder Treatment
- Central Venous Catheters and Hemodialysis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- Hemoglobinopathies and Related Disorders
- Injury Epidemiology and Prevention
- Pain Management and Opioid Use
- Organ Transplantation Techniques and Outcomes
- Nursing Roles and Practices
- Atrial Fibrillation Management and Outcomes
Johns Hopkins University
2013-2025
University of Baltimore
2021
Universitat de Barcelona
1971-2014
Howard University
2014
American Association for the Surgery of Trauma
2014
American International Group (United States)
2014
Vanderbilt University Medical Center
2014
Johns Hopkins Medicine
2014
Policlinica Metropolitana
2010
Hospital Clínic de Barcelona
1978-2001
The National Trauma Data Bank (NTDB) is an invaluable resource to study trauma outcomes. Recent evidence suggests the existence of great variability in covariate handling and inclusion multivariable analyses using NTDB, leading differences quality published studies potentially benchmarking centers. Our objectives were identify best possible mortality risk adjustment model (RAM) define minimum number covariates required adequately predict NTDB.Analysis NTDB 2009 was performed RAM for...
The Baumgartner perfusion technique was used as an experimental model to study the combined influence of red cell (RBC) and platelet counts on interaction platelets with subendothelium. At normal hematocrit a count 100,000 per microliter, adhesion aggregate (PAG) formation subendothelium were statistically decreased. lower (50,000/μliter), there even more marked reduction in PAGs. critical role RBCs demonstrated experiments at low hematocrit; PAGs impaired perfusions 20 percent any tested....
Twenty‐one unrelated Caucasian patients with Primary Biliary Cirrhosis were typed for HLA—A, B, C and HLA‐DRw antigens. The antigens HLA‐A1, HLA‐B8 HLA‐DRw3 found in increased frequency relation to the control group. When P values corrected number of tested only increase HLA—DRw4 remained significantly different from group ( corr. < 0.004). antigen HLA—DRw3 was carried by 12 out 21 (57.1%) comparison 11 74 (14.8%) normal subjects.
Cell-free supernatant fluids obtained from BCG-sensitized lymph node cells (6 × 10 6 cell/ml) incubated in tissue culture flasks containing heat-killed BCG (5 μg/ml) induced extensive development of multinucleated giant when with normal alveolar macrophages. In contrast, after incubation similar samples the same cell population (i) no mycobacteria, (ii) Escherichia coli , or (iii) Bacillus subtilis failed to produce added Giant-cell formation was observed experiments using Nocardia...
Although opioid abuse is a rising epidemic in the USA, there are no studies to date on incidence of persistent use following injuries. Therefore, aims this study are: (1) examine among nationally representative sample injured and non-injured populations; (2) evaluate whether an injury independent predictor use.Data from Medical Expenditure Panel Survey were pooled (years 2009-2012). Adults followed for about 2 years, during which they surveyed status every 4-5 months. To determine injuries...
OBJECTIVE: To determine whether intrawound vancomycin changes the bacteriology of surgical site infection pathogens and investigate emergence antibiotic-resistant pathogens. METHODS: Design: Secondary analysis phase III, prospective, randomized clinical trial. Setting: Thirty-six US trauma centers. Patient Selection Criteria: Patients who became infected after fixation tibial plateau or pilon fracture. Outcome Measures Comparisons: Pathogen types bacterial susceptibilities as determined from...
The incidence of cytotoxic antibodies in relation to the number pregnancies and different periods gestation was analysed sera from 2,686 pregnant women. In all groups, except among women more than five times, a significant decline active occurred during last trimester gestation.
The possible platelet-aggregating effect of plasma from systemic lupus erythematosus (SLE) patients (n = 19) was investigated under flow conditions. Aliquots the SLE plasmas with 10) or without 9) anticardiolipin antibodies (ACAs) were added to anticoagulated blood (1:20, vol/vol). Plasma normal donors used as a control. Blood incubated for 15 minutes at 37 degrees C and then perfused through annular chambers containing denuded arterial segments. Perfusions performed 10 shear rate 800 sec-1....
Abstract Even though it is generally held that cryoprecipitate and fraction I‐0 correct the prolonged bleeding time (BT) in patients with von Willebrand disease (VWD), perusal of reported data indicates correction usually short‐lasting often partial. We decided to do a controlled study relationship between multimeric structure factor (VWF) BT five severe (type III) VWD after infusion three plasma concentrates (“wet” cryoprecipitate, lyophilized I‐0) given random order. The dosage was...
Many rural, low-income, and historically underrepresented minority communities lack access to trauma center services, including surgical care injury prevention efforts. Along with features of the built social environment at incident locations, geographic barriers services may contribute disparities. This study sought classify event locations based on scene, examine patterns in individual patient demographics, characteristics, mortality by location class.Data from 2015 Maryland Adult Trauma...
Peripherally inserted central catheters (PICCs) play a crucial role in providing long-term intravenous therapy for patients requiring extended vascular access. With multiple PICC types available, understanding their cost-effectiveness is essential healthcare decisions that balance clinical benefits with economic considerations. This study assesses the and outcomes of chlorhexidine-coated PICCs (Type A) versus standard B), aiming to guide best practices access by addressing gap comprehensive...
This study was conducted to assess the cost-effectiveness of chlorhexidine-coated (AGBA) peripheral insertion central catheters (PICCs) versus standard PICCs for managing catheter-related complications among patients with hematologic disease. A decision tree health economic model developed, incorporating quality-adjusted life years (QALYs) derived from literature, as well complication rates and per-patient costs a randomized controlled trial. The base case incremental ratio (ICER) assessed...
The COVID-19 pandemic has had a profound impact on the world. While disease is currently under control, emergence of new coronavirus variants with potential underscores need for more universal vaccines. This study evaluates immunogenicity in non-human primates two broad-spectrum nasal vaccine candidates called PanCoV. preparations are based highly conserved regions SARS-CoV-2, specifically nucleocapsid (N) and S2 subunit from Spike protein, which include several relevant T-cell epitopes have...
Repeated injuries, as known injury recidivism, pose a significant burden on population health and healthcare settings. Therefore, identifying those at risk of recidivism can highlight targeted populations for primary prevention in order to improve reduce expenditures. There has been limited research factors associated with the U.S. Using population-based sample, we aim to: 1) identify prevalence among non-institutionalized adults; 2) investigate trend nationwide rates over time.Using Medical...
To describe current state-level policies in the United States, January 1, 2007-June 2017, limiting high morphine equivalent daily dose (MEDD) prescribing.