A5080957453- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Systemic Sclerosis and Related Diseases
- Dermatological and COVID-19 studies
- Bone health and treatments
- Inflammatory Myopathies and Dermatomyositis
- Cancer Diagnosis and Treatment
- Inflammasome and immune disorders
- Sarcoidosis and Beryllium Toxicity Research
- Quinazolinone synthesis and applications
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Autoimmune and Inflammatory Disorders Research
- Telomeres, Telomerase, and Senescence
- Medical Imaging and Pathology Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Celiac Disease Research and Management
- Rheumatoid Arthritis Research and Therapies
Complejo Asistencial Universitario de Palencia
2025
Research Institute Hospital 12 de Octubre
2018-2022
Hospital Universitario 12 De Octubre
2021
Universidad Complutense de Madrid
2020
Hospital de León
2018
Universidad de León
2017
Center for Rheumatology
2016
The impact of inflammatory rheumatic diseases on COVID-19 severity is poorly known. Here, we compare the outcomes a cohort patients with matched control to identify potential risk factors for severe illness.In this comparative study, identified hospital PCR+COVID-19 chronic arthritis (IA) or connective tissue (CTDs). Non-rheumatic controls were randomly sampled 1:1 and by age, sex PCR date. main outcome was COVID-19, defined as death, invasive ventilation, intensive care unit admission...
Background The susceptibility of patients with rheumatic diseases and the risks or benefits immunosuppressive therapies for COVID-19 are unknown. Methods We performed a retrospective study under follow-up in rheumatology departments from seven hospitals Spain. matched updated databases severe acute respiratory syndrome coronavirus 2-positive PCR tests hospital to same reference populations. Rates PCR+ confirmed were compared among groups. Results Patients chronic inflammatory had 1.32-fold...
Age and comorbidity are the main determinants of COVID-19 outcome. Shorter leukocyte telomere length (TL), a hallmark biological aging, has been associated with worse outcomes. We sought to determine TL in patients severe requiring hospitalization analyze whether clinical outcomes post-COVID-19 manifestations shorter TL.We analyzed 251 PCR-confirmed COVID-19, hospitalized first months pandemics. determined PBL at admission by quantitative-PCR (qPCR) analysis patients. A healthy cohort from...
Abstract Background/Aims KL-6 and IL-18 have been investigated as potential lung-specific biomarkers in different types of interstitial lung disease (ILD), including systemic sclerosis (SSc). However, their predictive significance for ILD detection, progression, mortality remains unclear. The study aimed to assess the discriminative capabilities differentiating between various grades fibrosis identified through semiquantitative CT extension SSc-ILD compare diagnostic performance these with...
Abstract Background/Aims Interstitial lung disease (ILD) is a common pulmonary manifestation in idiopathic inflammatory myopathies (IIMs), significantly impacting morbidity and mortality. This study aims to investigate the influence of immunological radiological profiles at baseline on both mortality development ILD individuals with IIM. Methods A retrospective analysis was conducted cohort IIM patients, stratified based presence or absence ILD. Univariate multivariate Cox proportional...
ABSTRACT Background The susceptibility of patients with rheumatic diseases, and the risks or benefits immunosuppressive therapies for COVID-19 are unknown. Methods We performed a retrospective study under follow-up in rheumatology departments from seven hospitals Spain. matched updated databases SARS-CoV-2 positive PCR tests hospital to same reference populations. Rates PCR+ confirmed were compared among groups. Results Patients chronic inflammatory diseases had 1.32-fold higher prevalence...
ABSTRACT Background The impact of inflammatory rheumatic diseases on COVID-19 severity is poorly known. Here we compare the outcomes a cohort patients with matched control to identify potential risk factors for severe illness. Methods In this comparative study, identified hospital PCR+ chronic arthritis (IA) or autoimmune/immunomediated (AI/IMID). Non-rheumatic controls were randomly sampled 1:1, and by age, sex, PCR date. main outcome was COVID-19, defined as death, invasive ventilation,...
Background: The impact of chronic inflammatory rheumatic diseases on COVID-19 severity is poorly known. Here we compare the outcomes a cohort patients with matched control to identify potential risk factors for severe illness. Methods: In this comparative study, systematically identified hospital PCR+ arthritis (IA) or autoimmune/immunomediated (AI/IMID). Non-rheumatic controls were randomly sampled 1:1, and by age, sex, PCR date. main outcome was COVID-19, defined as death, invasive...
<h3>Background</h3> Interstitial lung disease (ILD) associated with Rheumatoid Arthritis (RA) has a poor prognosis. Treatments such as anti-TNF, have been implicated in the exacerbation of an ILD. <h3>Objectives</h3> Our objective is to evaluate and compare evolution ILD patients RA treated Abatacept (ABA), Rituximab (RTX) Tocilizumab (TCZ) after 1 year treatment. <h3>Methods</h3> Retrospective multicentre study AR ABA, RTX TCZ at standard doses. The was diagnosed by CT. efficacy evaluated...
<h3>Background</h3> The indication or use of zoledronic acid on the Paget9s disease bone was approved in 2005. Recent studies point out administration a single intravenous dose this medicine as first therapeutic option. <h3>Objectives</h3> aim study is to determine whether there improvement ALP values among patients with after and analyze greater group previously treated oral bisphosphonates who have not received prior treatment. <h3>Methods</h3> This retrospective which included 49 that...
<h3>Background</h3> Disease modifying antirheumatic drugs (DMARDs) such as methotrexate (MTX), leflunomide (LFN) or antiTNFα have been implicated in development/exacerbation of Interstitial lung disease (ILD)of rheumatoid arthritis (RA). Several radiological patterns ILD described: i) usual interstitial pneumonia (UIP), ii) nonspecific (NSIP), iii) obliterating bronchitis (OB), and iv) Organized (OP) <h3>Objectives</h3> To assess the response to Abatacept (ABA) these <h3>Methods</h3>...
<h3>Background</h3> The zoledronate is a bisphosphonate widely used in the treatment of bone pathologies such as Paget9s disease and osteoporosis, due to its convenient dosage (annual infusion), rate therapeutic compliance excellent safety profile. <h3>Objectives</h3> Our objective this study describe clinical demographic features patients treated with our hospital over past five years, according different indications. <h3>Methods</h3> This retrospective observational that has included 186...