Ana Pérez‐Ayala
A5103100822- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Bacterial Identification and Susceptibility Testing
- Infectious Diseases and Mycology
- Pneumocystis jirovecii pneumonia detection and treatment
- Plant Pathogens and Fungal Diseases
- Pneumonia and Respiratory Infections
- Mycotoxins in Agriculture and Food
- Fungal Biology and Applications
- Sinusitis and nasal conditions
- Nail Diseases and Treatments
- Renal Transplantation Outcomes and Treatments
- Hematological disorders and diagnostics
- Antibiotic Use and Resistance
- Neutropenia and Cancer Infections
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Research Institute Hospital 12 de Octubre
2020-2024
Hospital Universitario 12 De Octubre
2019-2024
Universidad Complutense de Madrid
2021
We aimed to assess the percentage of azole resistance in Aspergillus fumigatus Spain.Thirty participating Spanish hospitals stored all morphologically identified A. sensu lato clinical isolates-regardless their significance-from 15 February 14 May 2019. Isolates showing according EUCAST 9.3.2 methodology were molecularly and cyp51A gene was studied stricto isolates.Eight hundred forty-seven isolates from 725 patients collected 29 (A. (n = 828) cryptic species 19)). mostly lower respiratory...
Fluconazole-resistant Candida parapsilosis is a matter of concern.
Abstract Objectives We prospectively monitored the epidemiology and antifungal susceptibility of Candida spp. from blood cultures intra-abdominal samples in patients admitted to hospitals Madrid area. Methods Between 2019 2021, we collected incident isolates [one per species, patient compartment (blood versus samples)] any 16 located Madrid. studied susceptibilities amphotericin B, triazoles, micafungin, anidulafungin ibrexafungerp following EUCAST E.Def 7.3.2 procedure. Results A total 2107...
ABSTRACT We previously conducted a multicenter surveillance study on Candida epidemiology and antifungal resistance in Madrid (CANDIMAD study; 2019–2021), detecting an increase fluconazole-resistant parapsilosis . here present data isolates collected 2022. Furthermore, we report the trends during entire period, including analysis per ward of admission. spp. incident from blood cultures intra-abdominal samples patients cared for at 16 hospitals Madrid, Spain, were tested with EUCAST E.Def...
The pathogenic yeast Candida glabrata has become a public health issue due to the increasing number of echinocandin resistant clinical strains reported. In this study, acquisition and development resistance antifungal class were studied in serial C. isolates from five patients admitted two Spanish hospitals with profile against echinocandins associated different mutations hot-spot 1 FKS2 gene. For these susceptible FKS wild-type obtained prior ones also investigated. Isolates genotyped using...
The diagnosis of invasive aspergillosis (IA) can be problematic in solid organ transplantation (SOT). prognosis greatly varies according to the type transplant, and impact prophylaxis is not well defined.The Diaspersot cohort analyses IA SOT Spain during last 10 years. Proven probable/putative was included.We analysed 126 cases IA. incidences were as follows: 6.5%, 2.9%, 1.8% 0.6% for lung, heart, liver kidney transplantation, respectively. EORTC/MSG criteria confirmed only 49.7% episodes....
Candidaemia and invasive candidiasis are typically hospital-acquired. Genotyping isolates from patients admitted to different hospitals may be helpful in tracking clones spreading across hospitals, especially those showing antifungal resistance.We characterized Candida clusters by studying (C. albicans, n = 1041; C. parapsilosis, 354, tropicalis, 125) blood cultures (53.8%) intra-abdominal samples (46.2%) collected as part of the CANDIMAD (Candida Madrid) study Madrid (2019-2021)....
COVID-19-associated pulmonary aspergillosis (CAPA) have been documented during the COVID-19 pandemic. The vast majority of these patients do not meet classic EORTC/MSGERC criteria for invasive aspergillosis. question arises as to whether there may an over-diagnosis this disease. Here we review our experience and analyze evolution 27 who were diagnosed with CAPA hospital admission. Surviving followed-up a mean time 15 months (SD 3.78) by group experts clinical records diseased reviewed. After...