A5087250719- Lymphoma Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Chronic Lymphocytic Leukemia Research
- Estrogen and related hormone effects
- Chronic Myeloid Leukemia Treatments
- T-cell and Retrovirus Studies
- Cancer, Lipids, and Metabolism
- Fibroblast Growth Factor Research
- Metastasis and carcinoma case studies
- Cancer Mechanisms and Therapy
- Cell death mechanisms and regulation
- Cytokine Signaling Pathways and Interactions
- Polyomavirus and related diseases
- Cancer Genomics and Diagnostics
- Eosinophilic Disorders and Syndromes
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related Molecular Pathways
- Plant Virus Research Studies
- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Acute Myeloid Leukemia Research
- Protein Kinase Regulation and GTPase Signaling
- Liver Diseases and Immunity
- Receptor Mechanisms and Signaling
- Genetic factors in colorectal cancer
Instituto de Investigación Marqués de Valdecilla
2015-2024
Universidad de Cantabria
2012-2024
University of Milan
2024
Marqués de Valdecilla University Hospital
2011-2021
Instituto de Biomedicina y Biotecnología de Cantabria
2008-2018
National Institutes of Health
2007-2014
National Institute of Dental and Craniofacial Research
2010-2014
Fundación Marques de Valdecilla
2012-2014
Aichi Cancer Center
2013
Hospital Universitario Infanta Sofía
2013
Squamous cell carcinomas of head and neck (HNSCC) are associated with immune, inflammatory, angiogenic responses involving interleukin-6 (IL-6). This article reports an ultrasensitive electrochemical immunosensor for human IL-6 proof-of-concept studies detection in HNSCC cells. Single wall carbon nanotube (SWNT) forests attached capture antibodies (Ab1) were used sandwich immunoassay protocol using enzyme label horseradish peroxidase (HRP) to measure very low (≤30 pg mL−1) elevated levels...
Merkel cell carcinoma (MCC) is a highly malignant neuroendocrine tumor of the skin whose molecular pathogenesis not completely understood, despite role that polyomavirus can play in 55–90% cases. To study potential mechanisms driving this disease clinically characterized cases, we searched for somatic mutations using whole-exome sequencing, and extrapolated our findings to functional biomarkers reporting on activity mutated pathways. Confirming previous results, polyomavirus-negative tumors...
There is conflicting evidence regarding the prevalence of and risk factors for metabolic-associated fatty liver disease (MAFLD) in patients with inflammatory bowel (IBD). We aimed to determine MAFLD IBD patients.Cross-sectional, case-control study included all consecutive treated at 2 different university hospitals. Controls were subjects randomly selected from general population matched by age, sex, type diabetes status, body mass index a 1:2 ratio. was confirmed controlled attenuation...
Synthetic progesterone used in contraception drugs (progestins) can promote breast cancer growth, but the mechanisms involved are unknown. Moreover, it remains unclear whether cytoplasmic interactions between receptor (PR) and estrogen alpha (ERα) required for PR activation. In this study, we a murine progestin-dependent tumor to investigate role of ERα progestin-induced cell proliferation. We found that treatment with progestin medroxyprogesterone acetate (MPA) induced expression activation...
Abstract Fibroblast growth factor (FGF) receptor 2 (FGFR-2) polymorphisms have been associated with an increase in estrogen and progesterone (PR)-positive breast cancer risk; however, a clear mechanistic association between FGFR-2 steroid hormone receptors remains elusive. In previous works, we shown cross talk FGF2 progestins mouse mammary carcinomas. To investigate the mechanisms underlying these interactions to validate our findings human setting, used T47D cells tissue samples. We showed...
Interleukin-21 (IL-21) controls the differentiation of T-helper Th17 cells and induces production IL-17 in this T-cell subtype. The aim study is to determine relative expression IL-21 gingival tissues chronic periodontitis patients correlate/associate with proinflammatory cytokines clinical parameters disease.Samples biopsies were collected from (n = 10) 8). mRNA expressions IL-21, IL-1β, IL-6, IL-17, IL-23, IL-10, transforming growth factor-β1 (TGF-β1) quantified using real-time reverse...
Abstract Untreated chronic myeloid leukemia (CML) progresses from phase to blastic crisis (BC). Increased genomic instability, deregulated proliferation, and loss of differentiation appear associated BC, but the molecular alterations underlying progression CML are poorly characterized. MYC oncogene is frequently in human cancer, often with tumor progression. Genomic instability induction aberrant DNA replication described as effects MYC. In this report, we studied activities cell lines...
Summary Background The malignant mechanisms that control the development of cutaneous T-cell lymphoma (CTCL) are beginning to be identified. Recent evidence suggests disturbances in specific intracellular signalling pathways, such as RAS–mitogen-activated protein kinase, receptor (TCR)–phospholipase C gamma 1 (PLCG1)–nuclear factor activated T cells (NFAT) and Janus kinase (JAK)–signal transducer activator transcription (STAT), may play an essential role pathogenesis CTCL. Objectives To...
Some chronic inflammatory skin diseases, such as psoriasis, have been associated with an increased prevalence of non-alcoholic fatty liver disease (NAFLD). Nevertheless, this in hidradenitis suppurativa (HS) has not assessed to date.To determine the NAFLD patients HS and risk factors disorder.This case-control study enrolled 70 150 age- gender-matched controls who were evaluated by hepatic ultrasonography (US) transient elastography (TE) after excluding other secondary causes disease. The...
Abstract Although mutant Ras proteins were originally described as transforming oncoproteins, they induce growth arrest, senescence, and/or differentiation in many cell types. c-Myc is an oncogenic transcription factor that cooperates with cellular transformation and oncogenesis. However, the Myc-Ras relationship largely unknown. Here, we have analyzed effects of on PC12-derived cells (UR61 line), harboring inducible N-Ras oncogene. In these cells, activation induces neuronal-like by a...
Neuroblastoma is one of the most genomically heterogeneous childhood malignances studied to date, and molecular events that occur during course disease are not fully understood. Genomic studies in neuroblastoma have showed only a few recurrent mutations low somatic mutation burden. However, none these has examined arising disease, nor they systemically expression mutant genes. Here we performed genomic analyses on tumors taken 3.5 years from patient (bone marrow biopsy at diagnosis, adrenal...
Even though RAS usually acts as a dominant transforming oncogene, in primary fibroblasts and some established cell lines Ras inhibits proliferation. This can explain the virtual absence of mutations types tumors, such chronic myeloid leukemia (CML). We report that CML line K562 induces p21Cip1 expression through Raf-MEK-ERK pathway. Because cells are deficient for p15INK4b, p16INK4a, p14ARF, p53, this would be main mechanism whereby up-regulates p21 these cells. Accordingly, we also found...