A5004468871- Plant Reproductive Biology
- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- Listeria monocytogenes in Food Safety
- Inflammatory Bowel Disease
- Plant tissue culture and regeneration
- Chromosomal and Genetic Variations
- Cell Image Analysis Techniques
- Spectroscopy Techniques in Biomedical and Chemical Research
- Plant Surface Properties and Treatments
- Salmonella and Campylobacter epidemiology
- Microscopic Colitis
- Escherichia coli research studies
- Transgenic Plants and Applications
- Plant and animal studies
- Gastrointestinal motility and disorders
- Spectroscopy and Chemometric Analyses
- Genomics and Chromatin Dynamics
- Biocrusts and Microbial Ecology
- Gastroesophageal reflux and treatments
- Genetic Mapping and Diversity in Plants and Animals
- Plant-Microbe Interactions and Immunity
- Celiac Disease Research and Management
- Pregnancy and Medication Impact
- Silk-based biomaterials and applications
Purdue University West Lafayette
2003-2023
Nashville Oncology Associates
2015
Saint Thomas West Hospital
2010-2012
Cold Spring Harbor Laboratory
2000-2003
Indiana University – Purdue University Indianapolis
2003
Harvard University
1993-2000
Clemson University
2000
University of California, Davis
1992
University of Minnesota
1981-1991
California Institute of Technology
1983-1988
A detailed morphological description of wild‐type ovule development in Arabidopsis thaliana is presented. The entire process from the formation protrusion until eight‐nuclear endosperm stage described. study based on a light‐microscopical analysis stained and subsequently optically cleared whole‐mount ovules. It supplemented by confocal laser scanning microscopy propidium iodide‐stained has been shown that combination both techniques eliminates need for sections to large extent, hence allows...
Ovules are complex structures that present in all seed bearing plants and contained within the carpels flowering plants. site of megasporogenesis megagametogenesis and, following fertilization, develop into seeds. We combined genetic methods with anatomical morphological analyses to dissect ovule development. Here, we a detailed description development Arabidopsis ovules report on isolation two chemically induced mutants, bell (bel1) short integuments (sin1), altered Phenotypic indicated...
In plants, the outer epidermal cell wall and cuticle presents a semipermeable barrier that maintains external integrity of plant regulates passage various classes molecules into out organism. During vegetative development, cells remain relatively inert, failing to respond wounding or grafting. reproductive development fertilization, however, epidermis is developmentally more labile participates in two types contact-mediated interactions: organ fusion pollen hydration. Here we describe...
Arabidopsis thaliana is a small flowering plant with various properties that make it an excellent organism for experiments in molecular genetics. These include having nuclear genome, near absence of dispersed repetitive DNA, and generation time 4 to 5 weeks. In addition, mutations affect hormone synthesis response, many different enzyme activities, numerous developmental processes have been identified characterized.
Objective: To evaluate the efficacy and safety of a pH-sensitive, polymer-coated oral preparation mesalamine in patients with mildly to moderately active ulcerative colitis. Design: A multicenter, double-blind, placebo-controlled randomized trial. Setting: Five university-based medical centers, one inflammatory bowel disease center, three private practice sites. Patients: total 158 newly or previously diagnosed Intervention: (5-aminosalicylic acid) was used at 1.6 2.4 g/d for 6 weeks....
In higher plants, cell-cell recognition reactions taking place following pollination allow the selective restriction of self-pollination and/or interspecific pollination. Many these systems function by regulating process water transfer from cells found at stigmatic surface to individual pollen grain. Interspecific studies on cruciferous weed Arabidopsis thaliana revealed only a broad specificity such that all tested members crucifer family were recognized, whereas almost other species failed...
Although the plant epidermis serves primarily a protective role, during development some epidermal cells specialize, becoming competent to interact not only with pollen but also other cells. In former case, these interactions mediate recognition, germination, and growth responses and, in latter result interorgan fusions which, most commonly, alter floral architecture ways that are thought promote reproductive success. either all of initial signaling events must take place across cell wall...
Postgenital organ fusion occurs most commonly during reproductive development and is important in many angiosperms genesis of the carpel. Although a number mutants have been described that manifest ectopic fusion, little known about genes involved regulating this process. In article we describe characterization collection 29 Arabidopsis showing an phenotype. Mapping complementation analyses revealed mutant alleles define nine different loci distributed throughout genome. Multiple were...
ABSTRACT Understanding organogenesis remains a major challenge in biology. Specification, initiation, pattern formation and cellular morphogenesis, have to be integrated generate the final three-dimensional architecture of multicellular organ. To tackle this problem we chosen ovules flowering plant Arabidopsis thaliana as model system. In first step towards functional analysis ovule development, performed large-scale genetic screen isolated number sterile mutants with aberrant development....
Summary The outer epidermal plant cell wall and cuticle play an important role in regulating both abiotic biotic interactions between the its environment. In addition to acting as a protective barrier that limits water loss, effects of detrimental irradiation invasion by pathogens, epidermis also offers interface is inert organs ensures proper separation expansion at growing points plant. Here, we describe molecular cloning characterization HOTHEAD ( HTH ), gene required limit cellular...
Summary Background : Tegaserod is a 5‐hydroxytryptamine‐4 receptor partial agonist. Oral administration causes gastrointestinal effects resulting in increased motility and attenuation of visceral sensation. Aim To determine the long‐term safety tolerability tegaserod patients suffering from irritable bowel syndrome with constipation as predominant symptom altered habits. Method A multicentre, open‐label study flexible dose titration out‐patients constipation‐predominant syndrome. Results...
Ulcerative colitis (UC) is a chronic relapsing and remitting idiopathic inflammatory bowel disorder.To evaluate once-daily mesalamine (mesalazine) granules (MG) for maintenance of remission UC.Randomized, double-blind, placebo-controlled trial patients (n=209 MG, n=96 placebo) with UC in [revised Sutherland Disease Activity Index (SDAI) rectal bleeding=0, mucosal appearance <2] who took MG 1.5 g or placebo up to 6 months. Primary efficacy endpoint: the percentage remained relapse-free at...
The effects of preceding endoscopic mucosal resection (EMR) on the efficacy and safety radiofrequency ablation (RFA) for treatment nodular Barrett's esophagus (BE) is poorly understood. Prior studies have been limited to case series from individual tertiary care centers. We report results a large, multicenter registry. assessed EMR RFA BE with advanced neoplasia (high-grade dysplasia or intramucosal carcinoma) using US Registry, nationwide study patients treated at 148 institutions. Safety...