A5028189560- Inflammatory Bowel Disease
- Microscopic Colitis
- Colorectal Cancer Screening and Detection
- Autoimmune and Inflammatory Disorders
- Eosinophilic Esophagitis
- Immunodeficiency and Autoimmune Disorders
- Diverticular Disease and Complications
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Biosimilars and Bioanalytical Methods
- Liver Disease Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Liver Diseases and Immunity
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Anorectal Disease Treatments and Outcomes
- Autoimmune and Inflammatory Disorders Research
- Pharmaceutical studies and practices
- Adolescent and Pediatric Healthcare
- Tuberculosis Research and Epidemiology
- Chronic Lymphocytic Leukemia Research
- Clostridium difficile and Clostridium perfringens research
McGill University Health Centre
2016-2025
McGill University
2016-2025
Montreal General Hospital
2017-2025
University Gastroenterology
2025
Royal Victoria Hospital
2012-2022
Jackson and Tull (United States)
2021
Semmelweis University
2018-2021
Jewish General Hospital
2017-2021
Zrínyi Miklós National Defence University
2021
KU Leuven
2012-2019
OBJECTIVES: Endoscopic mucosal healing is a key endpoint for the treatment of ulcerative colitis (UC). The role microscopic activity in predicting disease relapse has not been fully assessed. We aimed to investigate predictive serologic and histologic markers on UC patients with endoscopically inactive disease. METHODS: Adult (Mayo 0) 12-month follow-up between 2008 2011 were retrospectively included. An expert pathologist evaluated all colonic biopsies (Geboes score) presence basal...
Importance The clinical effects of risankizumab (a monoclonal antibody that selectively targets the p19 subunit IL-23) for treatment ulcerative colitis are unknown. Objective To evaluate efficacy and safety when administered as an induction a maintenance therapy patients with colitis. Design, Setting, Participants Two phase 3 randomized trials were conducted. trial was conducted at 261 centers (in 41 countries) enrolled 977 from November 5, 2020, to August 4, 2022 (final follow-up on May 16,...
ABSTRACT Background and Aims We aimed to assess the impact of setons on perianal fistula outcomes in patients with fistulising Crohn's disease (PFCD) treated anti‐TNF therapy. Methods included their first therapy for PFCD after undergoing a pelvic MRI between 2005 2022 from 6 North American centres. Our exposure was one or more at time primary outcome major adverse (MAFO), composite repeat local surgical intervention, hospitalisation, faecal diversion PFCD, our secondary remission defined...
Background and aims:Current endoscopic activity scores for ulcerative colitis (UC) do not take into account the extent of mucosal inflammation. We have developed a simple index UC that takes severity distribution
Background: Ustekinumab is a fully human IgG1 monoclonal antibody that blocks the biologic activity of interleukin-12/23. approved for treatment plaque psoriasis and has been shown to be effective induction maintenance clinical response in anti-TNF resistant Crohn's disease (CD). The aim study was describe real-life experience with open-label use ustekinumab CD patients.
An intact and well-functioning enteric nervous system is necessary to efficiently organize gut function. Functional gastrointestinal disorders are pathological entities in which function impaired without a clearly established pathophysiology. On the basis of relative ease with intestinal biopsies can be obtained, taking advantage recently developed optical recording technique, we evaluated whether functional neuronal defects exist nerves patients dyspepsia (FD).The submucous plexus isolated...
Background Patients with long-standing UC have an increased risk for the development of colonic neoplastic lesions. Chromoendoscopy (CE) has been proven to enhance neoplasia detection while role virtual chromoendoscopy (VC) is still be defined. Objective To compare performance CE VC lesions in patients UC. Design A multicentre prospective randomised controlled trial. 131 were between methylene blue 0.1% (n=66) or narrow band imaging (NBI) (n=65). Biopsies taken from visible and surrounding...
Multiple studies have established the superior diagnostic accuracy of video capsule endoscopy (VCE) for diagnosis small bowel (SB) Crohn's disease (CD). However, data on clinical impact VCE in patients with CD are scarce. The aim this study was to examine and safety management CD. A retrospective, multicenter, cross-sectional study. cohort included consecutive SB who underwent 4 tertiary referral centers (1 Canada, 1 Sweden, 2 United Kingdom) from January 2008 October 2013. Patients were...
Patients with inflammatory bowel disease (IBD) are at high risk for non-alcoholic fatty liver (NAFLD). Longitudinal data on incident NAFLD lacking. We employed non-invasive methods to study incidence and predictors of NAFLD.This was a retrospective IBD patients without known followed clinic McGill University. defined as Hepatic Steatosis Index (HSI) ≥36 absence alcohol intake. Advanced fibrosis diagnosed by FIB-4 ≥2.67. Active partial Mayo score ≥3 ulcerative colitis, Harvey Bradshaw ≥ 5 or...
The original Geboes Score [OGS] is the most commonly used histological score in ulcerative colitis [UC], but rather complicated to use daily clinical practice. aim of this study was develop a Simplified [SGS] and compare it with OGS patients newly diagnosed UC. All UC at tertiary referral centre between 2005 2010, who had serial colonoscopies biopsies, were retrospectively included. 5-year endoscopic/histological evolution after diagnosis recorded. Histological activity scored by an...
Abstract Background Endoscopic healing in patients with ulcerative colitis predicted higher rates of clinical remission at 12 months follow-up. Meanwhile, active histologic disease did not affect time to relapse UC who achieved endoscopic while the presence basal plasmacytosis was associated relapse. [1] We aim evaluate impact baseline and histological on long-term as well UC-related emergency room (ER) visits, hospitalizations surgery. Methods This prospective observational study conducted...
Abstract Background Ulcerative Colitis (UC) is a chronic inflammatory bowel disease characterized by relapsing inflammation of the colon. Current therapeutic goals emphasize clinical and endoscopic remission; however, histological remission has emerged as an important target due to its association with reduced relapse rates improved long-term outcomes. Despite this, limited data exist on concordance activity between colonic segments, especially in UC patients remission. This study...
Inflammatory bowel disease (IBD) patients may be at risk for nonalcoholic fatty liver (NAFLD) due to chronic inflammation, hepatotoxic drugs, and alteration of the gut microbiota. Prospective data using accurate diagnostic methods are lacking. We prospectively investigated prevalence predictors NAFLD fibrosis by transient elastography (TE) with associated controlled attenuation parameter (CAP) in IBD as part a routine screening program. was defined CAP ≥248 dB/m. Significant (stage 2 or...
Background Histological remission has been proposed as a new treatment goal in patients with ulcerative colitis (UC) although no universal definition for microscopic activity exists. Aim We evaluated the accuracy of histological to predict clinical relapse UC both and endoscopic remission. Methods Asymptomatic (Mayo sub‐score 0 or 1) undergoing surveillance colonoscopy two referral hospitals were prospectively recruited. All colonic biopsies analyzed according Geboes’ score (GS) presence...
Faecal calprotectin [FC] is a reliable surrogate marker for disease activity in ulcerative colitis [UC]; however, there are no consensus cut-off values remission. The study aim was to correlate FC with Mayo Endoscopic Score [MES] and histological of UC patients clinical remission.Our recruited adult at the McGill IBD Center between 2013 2017. Patients remission [partial score ≤2], undergoing endoscopy or dysplasia surveillance, were enrolled. Before bowel preparation, collected. MES...