A5009358895- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Gastrointestinal motility and disorders
- Gastric Cancer Management and Outcomes
- Microscopic Colitis
- Radical Photochemical Reactions
- Oxidative Organic Chemistry Reactions
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Colorectal Cancer Screening and Detection
- Veterinary medicine and infectious diseases
- Gastrointestinal Bleeding Diagnosis and Treatment
- Glaucoma and retinal disorders
- Inflammatory Bowel Disease
- Esophageal Cancer Research and Treatment
- Plant Virus Research Studies
- Retinal Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Legume Nitrogen Fixing Symbiosis
- Microbial Natural Products and Biosynthesis
- Organic Chemistry Cycloaddition Reactions
- Fluorine in Organic Chemistry
Dokkyo Medical University
2025
Tohoku University
1991-2024
National Institute for Materials Science
2022-2024
The University of Tokyo
1989-2024
Miyagi Prefectural Hospital Organization
2021-2022
McMaster University
2005-2019
Guelph General Hospital
1998-2016
QB3
2012
University of California, Berkeley
2012
Joint BioEnergy Institute
2012
Eradication of Helicobacter pylori provides potential cure in the majority patients with peptic ulcer disease, and eradication rates more than 90% have been reported, using omeprazole combination two antimicrobials. The choice antimicrobials, dose regimen duration treatment varied between studies, however, an optimal still has to be established.We conducted international, randomized, double-blind, placebo-controlled study involving 100 each six groups 43 hospital gastrointestinal units...
OBJECTIVES From the Canadian Registry of patients with Upper Gastrointestinal Bleeding and Endoscopy (RUGBE), we determined clinical outcomes explored roles endoscopic pharmacologic therapies in a contemporary real-life setting. METHODS Analysis randomly selected endoscoped for nonvariceal upper gastrointestinal bleeding at 18 community tertiary care institutions between 1999 2002. Covariates were defined priori 30-day follow-up obtained. Logistic regression models identified predictors...
Background & AimsMost patients with Crohn's disease (CD) eventually require an intestinal resection. However, CD frequently recurs after We performed a randomized trial to compare the ability of infliximab vs placebo prevent recurrence.MethodsWe evaluated efficacy in preventing postoperative recurrence 297 at 104 sites worldwide from November 2010 through May 2012. All study had undergone ileocolonic resection within 45 days before randomization. Patients were randomly assigned (1:1) groups...
To develop a disease-specific QOL instrument (QOLRAD) addressing patient concerns in gastroesophageal reflux disease (GERD) and dyspepsia. Patients. 759 male (45%) female (55%) patients with mean age of 48.4 years (sd 15.2) were used the psychometric evaluation.A pilot version QOLRAD, Gastrointestinal Symptoms Rating Scale (GSRS) SF-36 completed prior to endoscopy. Items high ceiling effect, items measuring different construct, i.e. low squared multiple correlation (R < 0.5) other items,...
Summary Background: Uninvestigated dyspepsia is common in family practice. The prevalence of clinically significant upper gastrointestinal findings (CSFs) adult uninvestigated patients, and their predictability based on history, unknown. Methods: Prompt endoscopy was performed within 10 days referral, 1040 patients presenting with at 49 Canadian practitioner centres. Subsequent management strategies during a 6‐month follow‐up period were determined by the individual practitioners. Results:...
<h3>Abstract</h3> <b>Objective:</b> To determine whether a "test for <i>Helicobacter pylori</i> and treat" strategy improves symptoms in patients with uninvestigated dyspepsia primary care. <b>Design:</b> Randomised placebo controlled trial. <b>Setting:</b> 36 family practices Canada. <b>Participants:</b> 294 positive <i>H</i><i>pylori</i> (<sup>13</sup>C- urea breath test) of at least moderate severity the preceding month. <b>Intervention:</b> Participants were randomised to twice daily...
Laser speckle flowgraphy (LSFG) enables noninvasive quantification of the retinal circulation in glaucoma patients. In this study, we tested intrasession reproducibility LSFG-NAVI, a modified LSFG technique.Sixty-five eyes from 33 subjects (male (M):female (F) = 17:16) with mean age 49.4 ± 11.2 years were examined study. Two parameters indicating - coefficient variation (COV) and intraclass correlation (ICC) analyzed three times on same day that blur rate (MBR) was measured using LSFG-NAVI....
The management of Helicobacter pylori negative patients with dyspepsia in primary care has not been studied placebo-controlled studies.H. symptoms at least moderate severity (> or =4 on a seven-point Likert scale) were recruited from 35 centers. Patients randomized to 4-wk treatment omeprazole 20 mg od, ranitidine 150 bid, cisapride placebo, followed by on-demand therapy for an additional 5 months. Treatment success was defined as no minimal (score < = 2 out 7), and assessed after 4 wk 6...
Summary Background Currently there is no consensus on the optimal method to measure severity of dyspepsia symptoms in clinical trials. Aim To validate 7‐point Global Overall Symptom scale. Methods The scale uses a Likert ranging from 1 = problem 7 very severe problem. Validation was performed two randomized‐controlled trials ( n 1121 and 512). Construct validity: compared with Quality Life Reflux And Dyspepsia, Gastrointestinal Rating Scale, Disease Questionnaire 10 specific using Spearman...
The optically active form of tritium-labeled A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone), a pleiotropic autoregulator responsible for streptomycin production, resistance, and sporulation in Streptomyces griseus, was chemically synthesized. By using the radioactive A-factor, binding protein detected cytoplasmic fraction this organism. had an apparent molecular weight approximately 26,000, as determined by gel filtration. Scatchard analysis suggested that bound molar ratio...
The etiologies of functional dyspepsia (FD) are unclear, but in some studies, treatment with a proton pump inhibitor has been beneficial. objective this study was to evaluate the efficacy esomeprazole 40 mg once day compared placebo achieving symptom relief primary care patients FD.This randomized, placebo-controlled trial adult FD patients, who had at least moderate severity symptoms, defined as score > or =4 on 7-point Global Overall Symptom (GOS) scale. Patients were excluded if they...
Over the past decade, multiple clinical reports have demonstrated that use of propofol sedation for gastrointestinal endoscopy by gastroenterologists and trained nurses is safe effective in appropriately selected patients. Proposed benefits include rapid onset action, improved patient comfort clearance, as well prompt recovery discharge from unit. As a result medical evidence, number international professional societies endorsed endoscopy. In Canada, no formal guidelines currently exist....
Eyes with glaucoma are characterized by optic neuropathy visual field defects in the areas corresponding to disk damage. The exact cause for glaucomatous has not been determined. Myopia shown be a risk factor glaucoma. purpose of this study was determine whether significant correlation existed between microcirculation and retinal nerve fiber layer thickness (RNFLT) patients myopic disks.Sixty eyes 60 disks were studied; 36 (men:women = 19:17) 24 no ocular diseases 14:10). mean deviation (MD)...