A5068770639- Adipose Tissue and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Lipid metabolism and disorders
- Diet and metabolism studies
- Genetics, Aging, and Longevity in Model Organisms
- Regulation of Appetite and Obesity
- Sirtuins and Resveratrol in Medicine
- Peroxisome Proliferator-Activated Receptors
- Pancreatic function and diabetes
- Bariatric Surgery and Outcomes
- Periodontal Regeneration and Treatments
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Reconstructive Surgery and Microvascular Techniques
- Cardiac Valve Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Exercise and Physiological Responses
- Advanced NMR Techniques and Applications
- Diabetes Treatment and Management
- Muscle metabolism and nutrition
Université Laval
2015-2024
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2015-2024
Montreal Heart Institute
2014-2024
Hôpitaux Universitaires Henri-Mondor
2015-2018
Centre Hospitalier Universitaire Henri-Mondor
2017-2018
Hôpital Saint-Louis
2017
Centre hospitalier universitaire de Québec
2017
Manitoba Beekeepers' Association
2017
Paris-Est Sup
2016
Centre hospitalier de l'Université Laval
2008
Sir2 and insulin/IGF-1 are the major pathways that impinge upon aging in lower organisms. In Caenorhabditis elegans a possible genetic link between pathway has been reported. Here we investigate such mammals. We show Sirt1 positively regulates insulin secretion pancreatic beta cells. represses uncoupling protein (UCP) gene UCP2 by binding directly to promoter. cell lines which is reduced SiRNA, levels elevated blunted. The up-regulation of associated with failure cells increase ATP after...
Despite the possible role of impaired cerebral tissue oxygenation in age-related cognition decline, much is still unknown about changes brain pO2 with age. Using a detailed investigation barrel cortex healthy, awake aged mice, we demonstrate decreased arteriolar and These are exacerbated after middle-age. We further uncovered evidence presence hypoxic micro-pockets old mice. Our data suggests that from young to middle-age, well-regulated capillary oxygen supply maintains availability tissue,...
Gestational diabetes coincides with elevated circulating progesterone levels. We show that accelerates the progression of in female db/db mice. In contrast, RU486, an antagonist receptor (PR), reduces blood glucose levels both WT and Furthermore, female, but not male, PR−/− mice had lower fasting glycemia than PR+/+ showed higher insulin on injection. Pancreatic islets from were larger secreted more consequent to increase β-cell mass due proliferation. These findings demonstrate important...
Background Pulmonary arterial hypertension ( PAH ) is a vasculopathy characterized by enhanced pulmonary artery smooth muscle cell PASMC proliferation and suppressed apoptosis. This results in both increase pressure vascular resistance. Recent studies have shown the implication of signal transducer activator transcription 3 STAT 3)/bone morphogenetic protein receptor 2 BMPR 2)/peroxisome proliferator‐activated gamma PPAR γ) . activation induces downregulation, decreasing γ, which contribute...
Increased expression levels of the long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (Malat1) have been associated with enhanced proliferation and metastasis several cancer cell types. Hypoxia, a hallmark characteristic solid tumors, has linked to an increase in activity ATP-generating AMPK protein. Since Malat1 was recently shown be upregulated during hypoxia, objective this study determine contribution mechanistic pathways regulating low oxygen conditions. Compared...
Abstract Objective: This study examined the effects of topiramate (TPM), a novel neurotherapeutic agent reported to reduce body weight in humans, on components energy balance female Zucker rats. Research Methods and Procedures: A 2 × 3 factorial experiment was performed which two cohorts rats differing their phenotype (phenotype: lean, Fa/? ; obese, fa/fa ) were each divided into three groups defined by dose TPM administered (dose: 0, vehicle; 15, 15 mg/kg; 60, 60 mg/kg). Results: The...
Brown fat presence and metabolic activity has been associated with lower body mass index, higher insulin sensitivity better cardiometabolic profile in humans. We, others, have previously reported the of Ucp1, a marker brown adipocytes, human epicardial adipose tissue (eAT). Characterization physiological relevance Ucp1 within eAT, however, is still awaited. Here, we validate eAT its 'beige' nature. Using in-vitro analytical approaches, further characterize thermogenic potential demonstrate...
should be "pSUPERretro SiRNA-T1 (5′-gatgaagttgacctcctca-3′)".
Objective: To assess whether plasma IGFBP-2 is independently associated with components of the lipoprotein-lipid profile and to suggest a cutoff value that could identify subjects features metabolic syndrome. Methods: In this cross-sectional study, 379 Caucasian men from general population covering wide range BMI were recruited through media. Subjects type 2 diabetes, values > 40 kg/m2, or taking medication targeting glucose lipid metabolism blood pressure excluded. Anthropometric data...