Isabelle Archambeaud
A5090701850- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Pancreatitis Pathology and Treatment
- Hepatitis C virus research
- Alcohol Consumption and Health Effects
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Abdominal vascular conditions and treatments
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Esophageal and GI Pathology
- Cancer Mechanisms and Therapy
- Diet, Metabolism, and Disease
- Gastrointestinal disorders and treatments
- Cannabis and Cannabinoid Research
- Hepatitis B Virus Studies
- Gastric Cancer Management and Outcomes
- Liver Diseases and Immunity
- Esophageal Cancer Research and Treatment
- Biliary and Gastrointestinal Fistulas
- Liver physiology and pathology
Inserm
2010-2024
Centre Hospitalier Universitaire de Nantes
2015-2024
Nantes Université
2010-2024
Centre d'Investigation Clinique de Nantes
2024
Université Paris Cité
2021
PhysioPathologie des Adaptations Nutritionnelles
2010-2021
Centre de Recherche Épidémiologie et Statistique
2021
Hôpitaux Universitaires Henri-Mondor
2021
Hôpital Albert-Chenevier
2021
Université Paris-Est Créteil
2021
The efficacy of rifaximin in the secondary prevention overt hepatic encephalopathy (HE) is well documented, but its effectiveness preventing a first episode patients after transjugular intrahepatic portosystemic shunt (TIPS) has not been established.To determine whether prevents HE TIPS compared with placebo.Randomized, double-blind, multicenter, placebo-controlled trial. (ClinicalTrials.gov: NCT02016196).197 cirrhosis undergoing for intractable ascites or variceal rebleeding.Patients were...
BackgroundIn the phase III HIMALAYA study (NCT03298451) in unresectable hepatocellular carcinoma (uHCC), STRIDE (Single Tremelimumab Regular Interval Durvalumab) significantly improved overall survival (OS) versus sorafenib; durvalumab monotherapy was noninferior to sorafenib for OS. Results reported herein are from a four-year updated OS analysis of HIMALAYA.Patients and methodsParticipants with uHCC no previous systemic treatment were randomized (n=393), (n=389), or (n=389). The data...
T cell exclusion causes resistance to cancer immunotherapies via immune checkpoint blockade (ICB). Myeloid cells contribute by expressing signal regulatory protein-α (SIRPα), an inhibitory membrane receptor that interacts with ubiquitous CD47 control macrophage phagocytosis in the tumor microenvironment. Although CD47/SIRPα-targeting drugs have been assessed preclinical models, therapeutic benefit of selectively blocking SIRPα, and not SIRPγ/CD47, humans remains unknown. We report a potent...
Autoimmune hepatitis (AIH) is a rare disease characterized by an immune attack of the liver. This study consists comprehensive analysis alterations related to AIH at diagnosis, and during remission phase under treatment. A total 37 major lymphocyte populations were analyzed from peripheral blood new‐onset patients (AIHn; n = 14), with controlled (n 11), healthy subjects 14). Liver biopsy analyses performed complete phenotypic analysis. Four significantly altered in AIHn diagnosis compared...
<b>Background and study aim: </b>Esophageal video capsule endoscopy (ECE) is a new technique that allows examination of the esophagus using noninvasive approach. The aim this was to compare ECE with esophagogastroduodenoscopy (EGD) for diagnosis esophageal varices in patients cirrhosis. <b>Patients methods:</b> A total 330 cirrhosis no known were prospectively enrolled. Patients underwent first, followed by EGD (gold standard). endoscopists who performed blind result. Patient satisfaction...
The primary objective of this article is to identify risk factors for infected pancreatic necrosis (IPN) in patients admitted the intensive care unit (ICU) severe acute pancreatitis. We also described outcomes IPN.Acute pancreatitis common and associated with multiple, potentially life-threatening complications. Over last decade, minimally invasive procedures have been developed treat IPN.We retrospectively studied consecutive ICUs Nantes University Hospital France, between 2012 2015....
Abstract Transjugular intrahepatic portosystemic shunt (TIPS) has become essential in the treatment or prevention of portal hypertension‐related complications. In early 1990s, primary indication was refractory bleeding. It is now proposed for ascites bleeding and patients with vascular diseases liver. Thus, there are a growing number being treated TIPS all over world. The broadening indications, involvement multiple stakeholders, need an accurate selection, positioning relation to...
In patients with cirrhosis, the risk of hepatocellular carcinoma (HCC) depends upon age, gender and etiology liver disease. Few studies are available in Caucasian alcoholic or metabolic cirrhosis without viral hepatitis.Cross-sectional clinical data from 905 HCV- HBV-negative were prospectively collected four French centres. The factors for HCC identified by logistic regression analysis whole population a nested case-control study.The was (48%), (7%) mixed (45%). Patients predominantly male...
4073 Background: In the Phase 3 HIMALAYA study (NCT03298451) in uHCC, STRIDE (Single T Regular Interval D) significantly improved overall survival versus sorafenib (S) and had manageable safety (Abou-Alfa et al. NEJM Evid 2022). is approved for uHCC United States Japan recommended approval by European Medicines Agency. this exploratory post hoc analysis, we assessed temporal patterns of imAEs regimen HIMALAYA. Methods: Safety was participants (pts) who received ≥1 dose (T 300 mg [one dose]...