A5037048002- Hepatocellular Carcinoma Treatment and Prognosis
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Advanced Radiotherapy Techniques
- Radiopharmaceutical Chemistry and Applications
- Asthma and respiratory diseases
- Medical Imaging Techniques and Applications
- Eosinophilic Esophagitis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiation Dose and Imaging
- Medical Imaging and Pathology Studies
- Estrogen and related hormone effects
- Radiomics and Machine Learning in Medical Imaging
- Immune Response and Inflammation
- Radiation Therapy and Dosimetry
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Advanced X-ray and CT Imaging
- Reproductive System and Pregnancy
- Dermatology and Skin Diseases
- Liver Disease and Transplantation
- Lung Cancer Treatments and Mutations
- Liver physiology and pathology
Centre National de la Recherche Scientifique
2014-2025
Inserm
2014-2025
Université Toulouse III - Paul Sabatier
2011-2025
Institut Toulousain des Maladies Infectieuses et Inflammatoires
2021-2024
Centre Eugène Marquis
2012-2023
Université de Toulouse
2007-2023
Centre de Physiopathologie de Toulouse-Purpan
2008-2020
Zero to Three
2019
Institut Bergonié
2019
Université de Bordeaux
2019
Radioembolization of liver cancers using (90)Y-loaded microspheres is experiencing more widespread use. However, few data are available concerning the doses delivered to tumors and healthy liver. This retrospective study was conducted calculate tumor dosimetry (planned dose [T(plan) D]) nontumor in patients treated by glass determine whether could predict response survival.Thirty-six with hepatocellular carcinoma (HCC), including 16 portal vein thrombosis (PVT), were microspheres. The...
Prevalence of asthma is higher in women than men, but the mechanisms underlying this sex bias are unknown. Group 2 innate lymphoid cells (ILC2s) key regulators type inflammatory responses. Here, we show that ILC2 development greatly influenced by male hormones. Male mice have reduced numbers progenitors (ILC2Ps) and mature ILC2s peripheral tissues compared with females. In consequence, males exhibit susceptibility to allergic airway inflammation response environmental allergens less severe...
Increased IFN-α production contributes to the pathogenesis of infectious and autoimmune diseases. Plasmacytoid dendritic cells (pDCs) from females produce more upon TLR7 stimulation than pDCs males, yet mechanisms underlying this difference remain unclear. In article, we show that basal levels IFN regulatory factor (IRF) 5 in were significantly higher compared with males positively correlated percentage IFN-α-secreting pDCs. Delivery recombinant IRF5 protein into human primary increased...
Males and females exhibit profound differences in immune responses disease susceptibility. However, the factors responsible for sex tissue immunity remain poorly understood. Here, we uncovered a dominant role type 2 innate lymphoid cells (ILC2s) shaping sexual dimorphism within skin. Mechanistically, negative regulation of ILC2s by androgens leads to reduction dendritic cell accumulation activation males, along with reduced immunity. Collectively, our results reveal androgen-ILC2-dendritic...
Dendritic cells (DCs) play a pivotal role in controlling the balance between tolerance and immunity intestine. Gut conditioned CD103(+) DCs promote regulatory T (Treg) cell responses; however, little is known about that drive inflammation Here, we show monocyte-derived inflammatory express E-cadherin, receptor for CD103, intestinal inflammation. E-cadherin(+) accumulated inflamed mesenteric lymph nodes colon, had high expression of toll-like receptors, produced colitogenic cytokines, such as...
Estrogen treatment exerts a protective effect on experimental autoimmune encephalomyelitis (EAE) and is under clinical trial for multiple sclerosis therapy. Estrogens have been suspected to protect from CNS autoimmunity through their capacity exert anti-inflammatory as well neuroprotective effects. Despite the obvious impacts of estrogens pathophysiology EAE, dominant cellular target that orchestrates 17β-estradiol (E2) in EAE still ill defined. Using conditional estrogen receptor (ER)...
To evaluate the impact of dosimetry based on MAA SPECT/CT for prediction response, toxicity and survival, treatment planning in patients with hepatocellular carcinoma (HCC) treated (90)Y-loaded glass microspheres (TheraSphere®).TheraSphere® was administered to 71 inoperable HCC. quantitative analysis used calculation tumour dose (TD), healthy injected liver (HILD), total dose. Response evaluated at 3 months using EASL criteria. Time progression (TTP) overall survival (OS) were Kaplan-Meier...
Intestinal CD103(+) DC promote the differentiation of Foxp3(+) Treg from naïve CD4(+) T cells through mechanisms involving TGF-beta and dietary metabolite, retinoic acid (RA). In this study, we have analysed whether specialised features are conserved in colitis. Our results show that inflammation dampens tolerogenic properties MLN DC, which is associated with lower expression tgfbeta2 aldh1a2. Accordingly, taken colitic mice impaired their ability to induce instead favour emergence...
Abstract Human plasmacytoid dendritic cells (pDCs) play a major role in innate immunity through the production of type I IFNs after TLR engagement by pathogens. Sex-based differences function human pDCs have been established, with from women exhibiting enhanced TLR7-mediated IFN-α as compared males. In mice, we recently provided evidence for estrogens positive regulator pDC functions cell-intrinsic estrogen receptor α signaling, but did not exclude other X-linked factors, particularly pDCs....
Most animals display multiple behavioral states and control the time allocation to each of their activity phases depending on environment. Here we develop a new quantitative method analyze Caenorhabditis elegans states. We show that dwelling roaming two-state behavior C. is tightly controlled by concentration food in environment animal. Sensory perception through amphid neurons necessary extend while internal metabolic nutritional value needed induce dwelling. Our analysis also shows...
The objective of this study was to evaluate the response rate and survival hepatocellular carcinoma portal vein thrombosis (PVT) patients treated with (90)Y-loaded glass microspheres using a personalized dosimetry intensification concept.The were administered 41 PVT (main = 12; lobar/segmental 29). (99m)Tc-macroaggregated albumin SPECT/CT quantitative analysis used calculate tumor dose (TD), healthy injected liver (HILD), (ILD). Response evaluated at 3 mo criteria European Association for...
Biphenotypic sinonasal sarcoma (BSNS) is a locally aggressive tumor occurring in the region. It harbors both myogenic and neural differentiation characterized by PAX3 rearrangement with MAML3 as most frequent fusion partner, but partner of remains unidentified subset cases. About 70 cases have been reported so far. In this study, we report series 41 clinical, pathologic, molecular description. Twenty-five (61%) patients were female individuals, median age was 49 years. Tumors arose...
Abstract Dendritic cells (DC) are critical actors in the initiation of primary immune responses and regulation self-tolerance. The steroid sex hormone 17β-estradiol (E2) has been shown to promote differentiation DCs from bone marrow (BM) precursors vitro. However, estrogen receptor (ER) involved this effect not yet characterized. Using recently generated ERα- or ERβ-deficient mice, we investigated role ER isotypes DC acquisition effector functions. We report that estrogen-dependent...
Abstract Background & Aims Efficacy of radioembolization is derived from radioinduced damage, whereas tumour dosimetry not considered as yet in prospective clinical trials. Objectives This study evaluates the impact dose ( TD ), based on 99m Tc macroaggregated albumin MAA ) quantification, response and overall survival OS ). Materials Methods We consecutively included 85 patients with hepatocellular carcinoma treated 90 Y‐loaded glass microspheres. was calculated using a quantitative...
Abstract 17β-Estradiol (E2) has been shown to regulate GM-CSF– or Flt3 ligand–driven dendritic cell (DC) development through estrogen receptor (ER) α signaling in myeloid progenitors. ERα regulates transcription of target genes two distinct activation functions (AFs), AF-1 and AF-2, whose respective involvement varies a type– tissue-specific manner. In this study, we investigated the role AFs effector inflammatory DCs, steady-state conventional plasmacytoid DCs (pDC), using mouse lacking...
This study aimed at identifying prior therapy dosimetric parameters using 99mTc-labeled macro-aggregates of albumin (MAA) that are associated with contralateral hepatic hypertrophy occurring after unilobar radioembolization hepatocellular carcinoma (HCC) performed 90Y-loaded glass microspheres.The dosimetry data 73 HCC patients were collected to the treatment microspheres for unilateral disease. The injected liver dose (ILD), tumor (TD) and healthy (HILD) calculated based on MAA...
Several treatment strategies are used for selective internal radiation therapy with (90)Y-microspheres. The diversity of approaches does not favor the standardization prescribed activity calculation. To this aim, a fast 3-dimensional (3D) dosimetry method was developed (90)Y-microsphere planning and clinically evaluated retrospectively.Our 3D approach is based on voxel S values (VSVs) has been implemented in software tool VoxelDose. VSVs were previously calculated at fine size....
Type I IFN (IFN-I) production by plasmacytoid DCs (pDCs) occurs during acute HIV-1 infection in response to TLR7 stimulation, but the role of pDC-derived IFN-I controlling or promoting is ambiguous. We report here a sex-biased interferogenic phenotype for frequent single-nucleotide polymorphism human TLR7, rs179008, displaying an impact on key parameters infection. show allele rs179008 T determine lower protein abundance cells from women, specifically — likely diminishing mRNA translation...