A5063230873- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Child Nutrition and Feeding Issues
- Autism Spectrum Disorder Research
- Metabolism and Genetic Disorders
- Fermentation and Sensory Analysis
- Attention Deficit Hyperactivity Disorder
- Horticultural and Viticultural Research
- Cardiovascular Syncope and Autonomic Disorders
- Genetics and Neurodevelopmental Disorders
- Neurological Disorders and Treatments
- Muscle metabolism and nutrition
- Pharmaceutical studies and practices
- Exercise and Physiological Responses
- Mitochondrial Function and Pathology
- Multisensory perception and integration
- Liver Disease and Transplantation
- Coenzyme Q10 studies and effects
- Pharmacy and Medical Practices
- Hops Chemistry and Applications
- High Altitude and Hypoxia
- Cerebral Palsy and Movement Disorders
- Sensory Analysis and Statistical Methods
- Antioxidant Activity and Oxidative Stress
- Electrolyte and hormonal disorders
Tokushima Red Cross Hospital
2016-2023
Asahi Breweries (Japan)
2008-2022
Daiichi University of Pharmacy
2016
Tokushima Bunri University
2016
RELX Group (United Kingdom)
2010
RELX Group (United States)
2010
Hokkaido University
2003
Délégation Paris 5
1997
Université Paris Cité
1997
ABSTRACT Liver lipid peroxidation, nonheme iron, antioxidants, and protein oxidation were investigated in experimental alcohol–induced liver disease the rat. Wistar male rats intragastrically continuously infused for 4 weeks with a high–fat diet plus an ethanol or isocaloric amount of dextrose, maintaining high blood alcohol level (200–300 mg%). This model induced fatty liver, spotty necrosis, focal inflammation. pathology was associated enhanced peroxidation decrease major antioxidant...
There are several studies on oxidative stress of Autism Spectrum Disorder (ASD), but in these cases there is no study to measure and antioxidant capacity at the same time or considering childhood development. Therefore, this comprehensively assessed level ASD children by simultaneously measuring reactive oxygen metabolites (d-ROMs) biological potential (BAP). The subjects were Japanese, 77 typical development (TD) children, 98 samples plasma. divided into age groups: toddlers/preschool (2–6...
The behaviors of 3-mercaptohexan-1-ol (3MH) and 3-mercaptohexyl acetate (3MHA) during brewing processes were examined to establish their contributions the distinctive beer aroma. In hops, 3MH was detected in both U.S. European cultivars. concentration differed between cultivars, ranging from 10 120 μg/kg pellet, whereas occurrence 4-mercapto-4-methylpentan-2-one (4MMP) depended on growing region as well cultivar—4MMP not addition copper granules indicated that 4MMP more susceptible than...
Measurement of the levels derivatives reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) enables simultaneous assessment oxidation degree capacity, using same sample testing equipment. At present, reference values healthy adults are clarified, but value children is unknown. This study was undertaken to clarify age-related changes d-ROMs BAP in children.The population consisted 77 children, ranging age from 2 15 years, normal mental physical health as examined by...
Epilepsy is a common complication in patients with severe motor and intellectual disabilities (SMID). There are no reports as yet of the effects these medications vivo other than their epileptic efficacy. The purpose this study was to clarify newer antiepileptic drugs (AEDs) on blood biochemical parameters oxidative stress SMID epilepsy by comparing therapeutic between group receiving lamotrigine (LTG) levetiracetam (LEV) addition conventional AEDs (newer AED group) alone (old group).The...
The etiology of autism spectrum disorder (ASD) includes oxidative stress and brain inflammation. We investigated the relationship among markers, in vivo inflammatory substances, antioxidants that can be easily measured clinic compared them between children with ASD those typical development (TD).Sixty-one TD 199 untreated were investigated. They Japanese aged 2-15 years divided into <7 ≥7 years. Serum levels reactive oxygen metabolites (ROMs), high-sensitivity C-reactive protein (hsCRP),...
AbstractThis study compared amounts of 4-mercapto-4-methylpentan-2-one (4MMP), 3-mercaptohexan-1-ol (3MH), and 3-mercaptohexyl acetate (3MHA) in treated untreated hop cones hopped beers order to investigate the effects treatment hops field with Bordeaux mixture (copper sulfate). These three compounds contribute blackcurrant/muscat-like aroma characteristics some cultivars. In copper sulfate, 4MMP content was approx. 25% lower than those not treated. contrast, 3MH 3MHA contents were higher...
Abstract Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder, mainly characterized by impairment of social communication and restricted interests. ASD frequently accompanied attention deficit hyperactivity (ADHD), which carelessness, impulsivity (ASD/ADHD). It has been suggested that ADHD are associated with oxidative stress, is, patients ASD/ADHD in state increased stress. There currenr tly no objective or biological test criteria for evaluating the efficacy drug...
Background: The medical care of severe motor and intellectual disabilities (SMID) depends on the empirical care. Epileptic seizure specific to SMID is difficult suppress using anti-epileptic drugs, its tendency persist for long periods poses an issue. present study was undertaken evaluate relationship between epileptic in cases with oxidative stress living body by examining endogenous antioxidants, degree oxidation (reactive oxygen metabolites (d-ROMs)), biological antioxidant potential...
Dravet syndrome (DS) is an intractable epilepsy syndrome. The three-drug combination therapy of sodium valproate (VPA), clobazam (CLB) and stiripentol (STP) recommended worldwide.We present a case DS, in which treatment with CLB could not be continued because the appearance adverse reactions to it. Replacement topiramate (TPM) proved markedly effective.It suggested that VPA, TPM STP for DS epilepsy.
Patients with severe motor and intellectual disabilities (SMID) are those who have both physical disabilities. Intractable epilepsy is often associated SMID. The purpose of this study was to elucidate the relationship between SMID oxidative stress, clarify safety efficacy newer antiepileptic drugs (newer AEDs), lamotrigine levetiracetam.This conducted in 27 patients were treated AEDs. patient characteristics AEDs investigated. reactive oxygen metabolite (d-ROM) biological antioxidant...
Purpose: In hospitalized patients with severe motor and intellectual disabilities (SMID), we analyzed the association of SMID class to factors such as prevalence epilepsy, frequency seizures number concomitantly used anti-epileptic drugs (AEDs), evaluated usefulness addition new AEDs (gabapentin, topiramate, lamotrigine levetiracetam) treatment regimen. Results: The epilepsy in study population was about 60%. There were 39.5% who free epileptic during 6-year survey period remained...
Abstract Carbamazepine often causes drug‐induced hyponatremia. Hyponatremia due to carbamazepine may be improved by changing the same mechanism of action, lacosamide.
Fazit Eine geringgradige intraventrikuläre Blutung beeinträchtigt zerebrale und zerebelläre weiße Substanz, speziell im superioren zerebellären Pedunkel. Darüber hinaus kommt es bei jüngeren Frühgeborenen zu größeren Beeinträchtigungen der weißen Substanz des motorischen Strangs als älteren Frühgeborenen, so die Autoren.
Adsorption of the new generation antiepileptic drug E Keppra® dry syrup containing 50% levetiracetam to an automated dividing and packing machine was observed after dispensing by using machine. We examined loss variation in divided weight a pediatric dose syrup. When 1.4 g into 14 packs machine, per pack 10% - 27%. The high during early stage packaging Conversely, less than when 7.0 packs. 2.3%, which larger were under following conditions: particles average particle diameter 150 μm humidity...