A5007924561- T-cell and Retrovirus Studies
- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Animal Disease Management and Epidemiology
- Neutropenia and Cancer Infections
- Viral-associated cancers and disorders
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Blood disorders and treatments
- Polyomavirus and related diseases
- Cytomegalovirus and herpesvirus research
- Histone Deacetylase Inhibitors Research
- Hematological disorders and diagnostics
- Viral Infectious Diseases and Gene Expression in Insects
- Radiomics and Machine Learning in Medical Imaging
- Eosinophilic Disorders and Syndromes
- Neurological Complications and Syndromes
- Transplantation: Methods and Outcomes
- Fungal Infections and Studies
- Parvovirus B19 Infection Studies
- RNA Interference and Gene Delivery
- Amyotrophic Lateral Sclerosis Research
Toranomon Hospital
2015-2024
The University of Tokyo
2007-2024
Kogakuin University
2018
National Institute of Infectious Diseases
2007
A pilot study of a novel, reduced-toxicity, myeloablative conditioning regimen using intravenous busulfan 12.8 mg/kg, fludarabine 180 mg/m2, and melphalan 80 mg/m2 for single cord blood transplantation (CBT) was conducted at our institution. Fifty-one patients with myeloid malignancies not in remission were included this study. Their median age 59 years (range, 19 to 70 years), hematopoietic cell transplantation–specific comorbidity index score 3. With observation period 39.6 months 24.3...
Extranodal NK/T-cell lymphoma (ENKTCL) is an Epstein-Barr virus (EBV)-related neoplasm with male dominance and a poor prognosis. A better understanding of the genetic alterations their functional roles in ENKTCL could help improve patient stratification treatments. In this study, we performed comprehensive analysis 178 cases to delineate landscape mutations, copy number (CNA), structural variations, identifying 34 driver genes including six previously unappreciated ones, namely, HLA-B,...
ABSTRACT Limited data are available on micafungin breakthrough fungemia (MBF), that develops administration of micafungin, in patients with hematological disorders. We reviewed medical and microbiological records disorders who developed MBF between January 2008 June 2015. A total 39 were identified, Candida (30 strains) non- (9 fungal species recognized as causative strains. Among 35 stored strains, parapsilosis (14 strains), Trichosporon asahii (7 glabrata (5 other identified by sequencing....
Abstract Premalignant clonal expansion of human T-cell leukemia virus type-1 (HTLV-1)–infected cells occurs before viral carcinogenesis. Here we characterize premalignant and the multicellular ecosystem in HTLV-1 infection with without adult leukemia/lymphoma (ATL) by genome sequencing single-cell simultaneous transcriptome T/B-cell receptor surface protein analysis. We distinguish malignant phenotypes caused leukemogenesis dissect evolution different clinical behavior. Within...
Limited data are available on breakthrough fungemia, defined as fungemia that develops administration of antifungal agents, in patients with hematological disorders. We reviewed the medical and microbiological records adult diseases who had between January 2008 July 2019 at Toranomon Hospital Kajigaya Japan. A total 121 cases were identified. Of involved patients, 83, 11, 5, 22 receiving micafungin, voriconazole, itraconazole, liposomal amphotericin B, respectively, when occurred. causative...
Patients with von Hippel-Lindau disease (vHL) are at risk of developing spatially and temporally multiple clear cell renal carcinomas (ccRCCs), which offers a valuable opportunity to analyze inter- intra-tumor heterogeneity genetic immune profiles within the same patient. Here, we perform whole-exome RNA sequencing, digital gene expression, immunohistochemical analyses for 81 samples from 51 ccRCCs 10 patients vHL. Inherited clonally independent have less genomic alterations than sporadic...
Few data on breakthrough candidemia (BC), defined as that develops administration of antifungal agents (AFAs), in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients are available. The medical and microbiological records an allo-HSCT obtained between December 2008 2014 were reviewed. Of 768 cases, 26 developed BC. Among the causative strains, 22 strains stored identified by sequencing. following species isolated: Candida parapsilosis (9 strains), C. glabrata (4...
Recent recombinant viral vector-based AIDS vaccine trials inducing cellular immune responses have shown control of CXCR4-tropic simian-human immunodeficiency virus (SHIV) replication but difficulty in containment pathogenic CCR5-tropic simian (SIV) rhesus macaques. In contrast, controlled infection live attenuated SIV/SHIV can confer the ability to contain SIV superchallenge The specific responsible for this may be induced by not consistently vector vaccination, although those been...
Breakthrough viridans streptococcal bacteremia (VSB) in patients with hematological malignancy receiving levofloxacin prophylaxis is a major blood stream infection (BSI) occurring during febrile neutropenia. However, clinical data focused on VSB allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients are lacking.The medical records of allo-HSCT who received oral between January 2011 and August 2013 at Toranomon Hospital were reviewed to evaluate breakthrough VSB. Stored (VGS)...
Other iatrogenic immunodeficiency-associated lymphoproliferative disorders (OIIA-LPDs) occur in patients receiving immunosuppressive drugs for autoimmune diseases; however, their clinicopathological and genetic features remain unknown. In the present study, we analysed 67 with OIIA-LPDs, including 36 diffuse large B-cell lymphoma (DLBCL)-type 19 Hodgkin (HL)-type. After discontinuation of drugs, regression without relapse was achieved 22 58 patients. Spontaneous associated Epstein-Barr virus...
Langerhans cell histiocytosis (LCH) is a clonal neoplasm that shows diverse clinical manifestations and courses of disease progression. The etiology pathophysiology LCH remain uncertain. We describe the course 23-year-old Japanese woman with multi-system LCH, who showed rapid progression after steroid reduction developed multi-organ failure. Liver biopsy infiltration fatty degeneration. She was treated cytarabine, vincristine, prednisolone according to Japan study group 02 protocol, without...
Delayed neutrophil engraftment (NE) has been reported in cord blood transplantation (CBT) compared with other stem cell methods. The numbers of total nucleated cells (TNCs), CD34+ (generally ≥ 1 × 105/kg), and granulocyte/macrophage colony-forming units (CFU-GM) significantly impact NE. Splenomegaly exerts negative effects on NE, but the appropriate dose for patients splenomegaly not yet determined, especially CBT. We retrospectively investigated effect number infused NE through analysis...
There are few reports on the clinical course of proven invasive aspergillosis (IA) due to rare/cryptic species in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients. We retrospectively reviewed electronic medical records patients who underwent allo-HSCT between January 2012 and December 2018. Of 934 recipients, 10 were diagnosed with IA 61 probable IA. DNA sequencing was performed cases IA, Aspergillus could be identified level 8 cases. Three A. fumigatus, 5 species,...
A 55-year-old man was admitted to our institute undergo evaluation for proteinuria (5.4 g/day) with lambda-type Bence-Jones protein (BJP). Primary amyloid light chain (AL) amyloidosis and acquired factor X deficiency were diagnosed. High-dose melphalan combined autologous stem cell transplantation performed. After three years, the patient's normalized, he negative urinary BJP, his activity improved 105%. Serial renal biopsy showed no progression of deposition at a after 5 but slight increase...
Recent progress in genetic analysis technology has helped researchers understand the pathogenesis of acute myeloid leukemia (AML). Considering this progress, AML karyotype is still one most significant prognostic factors that provides risk-adapted treatment approaches. Karyotype changes during have been observed at times, but their impact sparse, especially on allogeneic stem cell transplantation (allo-SCT). Here, we retrospectively investigated effect chromosomal between diagnosis and...
Limited data are available on Stenotrophomonas maltophilia bloodstream infections (SM-BSIs) and the therapeutic efficacy of trimethoprim–sulfamethoxazole (SXT) against SM-BSI in umbilical cord blood transplant (uCBT) recipients. Medical microbiological records adult patients who received uCBTs between December 2008 2015 at Toranomon Hospital (Tokyo, Japan) were reviewed. The safety SXT evaluated only for recipients treated with ≥7 days intravenous (evaluation cohort). Of 561 uCBT recipients,...