A5026507037- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Neutropenia and Cancer Infections
- Lymphoma Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Antifungal resistance and susceptibility
- Histone Deacetylase Inhibitors Research
- Blood disorders and treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Eosinophilic Disorders and Syndromes
- Polyomavirus and related diseases
- Mesenchymal stem cell research
- Viral-associated cancers and disorders
- Fungal Infections and Studies
- Immune Cell Function and Interaction
- Neurological Complications and Syndromes
- Hematological disorders and diagnostics
- Nail Diseases and Treatments
- Cytomegalovirus and herpesvirus research
- Bone and Joint Diseases
- Radiomics and Machine Learning in Medical Imaging
- Ear and Head Tumors
Toranomon Hospital
2016-2025
A pilot study of a novel, reduced-toxicity, myeloablative conditioning regimen using intravenous busulfan 12.8 mg/kg, fludarabine 180 mg/m2, and melphalan 80 mg/m2 for single cord blood transplantation (CBT) was conducted at our institution. Fifty-one patients with myeloid malignancies not in remission were included this study. Their median age 59 years (range, 19 to 70 years), hematopoietic cell transplantation–specific comorbidity index score 3. With observation period 39.6 months 24.3...
The impact of anti-HLA antibodies, except for donor-specific anti-HLA-A, -B, -DRB1 on engraftment was retrospectively evaluated in 175 single cord blood transplantations (CBT). Patients and donors had been typed at HLA-A, antigens, antibodies screened before transplantation to avoid the use (CB) units with corresponding antigens. median age 59 (range, 17 74) years. Overall, 61% were male, 89% high-risk disease status, 77% received myeloablative conditioning regimens, over 80% heavily...
ABSTRACT Limited data are available on micafungin breakthrough fungemia (MBF), that develops administration of micafungin, in patients with hematological disorders. We reviewed medical and microbiological records disorders who developed MBF between January 2008 June 2015. A total 39 were identified, Candida (30 strains) non- (9 fungal species recognized as causative strains. Among 35 stored strains, parapsilosis (14 strains), Trichosporon asahii (7 glabrata (5 other identified by sequencing....
Limited data are available on breakthrough fungemia, defined as fungemia that develops administration of antifungal agents, in patients with hematological disorders. We reviewed the medical and microbiological records adult diseases who had between January 2008 July 2019 at Toranomon Hospital Kajigaya Japan. A total 121 cases were identified. Of involved patients, 83, 11, 5, 22 receiving micafungin, voriconazole, itraconazole, liposomal amphotericin B, respectively, when occurred. causative...
This is the first report of therapy-related mixed-phenotype acute leukemia (MPAL) characterized by B-cell, T-cell, and myeloid lineage phenotypes. A 68-year-old man, who was in complete remission after chemoradiotherapy for recurrent esophageal cancer, developed bacterial pneumonia with increasing blasts peripheral blood, a subsequent bone marrow biopsy revealed 85.2% blasts. flow cytometric analysis cytMPO+, CD19+, cytCD22+, cytCD3+ markers. The patient diagnosed MPAL (B/T/myeloid lineage)....
Few data on breakthrough candidemia (BC), defined as that develops administration of antifungal agents (AFAs), in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients are available. The medical and microbiological records an allo-HSCT obtained between December 2008 2014 were reviewed. Of 768 cases, 26 developed BC. Among the causative strains, 22 strains stored identified by sequencing. following species isolated: Candida parapsilosis (9 strains), C. glabrata (4...
Tyrosine kinase inhibitors (TKIs) are essential drugs for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. Cardiovascular or arteriothrombotic adverse events have been reported in patients treated with TKIs. We report 3 cases of Ponatinib-related vasospastic angina, which prophylactic administration nitrates calcium channel blockers was effective.
Breakthrough viridans streptococcal bacteremia (VSB) in patients with hematological malignancy receiving levofloxacin prophylaxis is a major blood stream infection (BSI) occurring during febrile neutropenia. However, clinical data focused on VSB allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients are lacking.The medical records of allo-HSCT who received oral between January 2011 and August 2013 at Toranomon Hospital were reviewed to evaluate breakthrough VSB. Stored (VGS)...
Other iatrogenic immunodeficiency-associated lymphoproliferative disorders (OIIA-LPDs) occur in patients receiving immunosuppressive drugs for autoimmune diseases; however, their clinicopathological and genetic features remain unknown. In the present study, we analysed 67 with OIIA-LPDs, including 36 diffuse large B-cell lymphoma (DLBCL)-type 19 Hodgkin (HL)-type. After discontinuation of drugs, regression without relapse was achieved 22 58 patients. Spontaneous associated Epstein-Barr virus...
Delayed neutrophil engraftment (NE) has been reported in cord blood transplantation (CBT) compared with other stem cell methods. The numbers of total nucleated cells (TNCs), CD34+ (generally ≥ 1 × 105/kg), and granulocyte/macrophage colony-forming units (CFU-GM) significantly impact NE. Splenomegaly exerts negative effects on NE, but the appropriate dose for patients splenomegaly not yet determined, especially CBT. We retrospectively investigated effect number infused NE through analysis...
There are few reports on the clinical course of proven invasive aspergillosis (IA) due to rare/cryptic species in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients. We retrospectively reviewed electronic medical records patients who underwent allo-HSCT between January 2012 and December 2018. Of 934 recipients, 10 were diagnosed with IA 61 probable IA. DNA sequencing was performed cases IA, Aspergillus could be identified level 8 cases. Three A. fumigatus, 5 species,...
Mantle cell lymphoma is considered an aggressive B-cell lymphoma. The optimal induction regimen remains controversial as no randomized controlled trial has compared the efficacy of different therapies.Herein, we performed a retrospective analysis clinical characteristics 10 patients who received treatment consisting rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) bendamustine, cytarabine (R-BAC) at Toranomon Hospital between November 2016 February 2022.Although...
Recent progress in genetic analysis technology has helped researchers understand the pathogenesis of acute myeloid leukemia (AML). Considering this progress, AML karyotype is still one most significant prognostic factors that provides risk-adapted treatment approaches. Karyotype changes during have been observed at times, but their impact sparse, especially on allogeneic stem cell transplantation (allo-SCT). Here, we retrospectively investigated effect chromosomal between diagnosis and...
Limited data are available on Stenotrophomonas maltophilia bloodstream infections (SM-BSIs) and the therapeutic efficacy of trimethoprim–sulfamethoxazole (SXT) against SM-BSI in umbilical cord blood transplant (uCBT) recipients. Medical microbiological records adult patients who received uCBTs between December 2008 2015 at Toranomon Hospital (Tokyo, Japan) were reviewed. The safety SXT evaluated only for recipients treated with ≥7 days intravenous (evaluation cohort). Of 561 uCBT recipients,...
Prognostic significance of different haematopoietic reconstitution among donor sources is sparse.1 The present retrospective study involved a large sample first-time cord blood transplantation (CBT) patients (n = 593), alongside control group unrelated bone marrow (uBMT) 113) at Toranomon Hospital, Tokyo, Japan. We evaluated how the recovery and kinetics lymphocytes within first 50 days post-transplant affect survival after day 50. Lymphocyte recipients who survived >50 was assessed on 20,...