A5043985252- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- T-cell and Retrovirus Studies
- Cutaneous lymphoproliferative disorders research
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- CNS Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Acute Myeloid Leukemia Research
- Sarcoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Monoclonal and Polyclonal Antibodies Research
- Histiocytic Disorders and Treatments
- Immunotherapy and Immune Responses
- Chronic Myeloid Leukemia Treatments
- Cancer Genomics and Diagnostics
- Eosinophilic Disorders and Syndromes
- Vascular Tumors and Angiosarcomas
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Cancer-related Molecular Pathways
- Immunodeficiency and Autoimmune Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Tumors and Oncological Cases
European Institute of Oncology
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2024
Ripamonti
2016-2024
University of Bologna
2013-2023
GNA University
1991-2023
Institute of Oncology Research
2023
Ministero della Salute
2021-2022
Istituto Tumori Bari
2019
Frankfurt Institute for Advanced Studies
2018
Mylan (Switzerland)
2018
Hairy-cell leukemia (HCL) is a well-defined clinicopathological entity whose underlying genetic lesion still obscure.We searched for HCL-associated mutations by performing massively parallel sequencing of the whole exome leukemic and matched normal cells purified from peripheral blood an index patient with HCL. Findings were validated Sanger in 47 additional patients HCL.Whole-exome identified five missense somatic clonal that confirmed on sequencing, including heterozygous mutation BRAF...
Since the publication of Revised European-American Classification Lymphoid Neoplasms in 1994, subsequent updates classification lymphoid neoplasms have been generated through iterative international efforts to achieve broad consensus among hematopathologists, geneticists, molecular scientists, and clinicians. Significant progress has recently made characterization malignancies immune system, with many new insights provided by genomic studies. They led this proposal. We followed same process...
The aim of the F2 study was to verify whether a prospective collection data would enable development more accurate prognostic index for follicular lymphoma (FL) by using parameters which could not be retrospectively studied before, and choosing progression-free survival (PFS) as principal end point.Between January 2003 May 2005, 1,093 patients with newly diagnosed FL were registered 942 individuals receiving antilymphoma therapy selected population. variables we used score definition means...
Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases Neoplasms cells are rare, their phenotypic biological definition is incomplete. Seeking identify antigens detectable in paraffin‐embedded sections that might allow a more complete, rational immunophenotypic histiocytic/dendritic cell neoplasms, (ILSG) stained tumours suspected type with panel 15 antibodies including those...
AIM: To assess a newly developed immunohistochemical detection system, the EnVision++. METHODS: A large series of differently processed normal and pathological samples 53 relevant monoclonal antibodies were chosen. chessboard titration assay was used to compare results provided by EnVision++ system with those APAAP, CSA, LSAB, SABC, ChemMate methods, when applied either manually or in TechMate 500 immunostainer. RESULTS: With vast majority antibodies, allowed two- fivefold higher dilutions...
Intravascular large B-cell lymphoma (IVLBCL) is a rare form of diffuse LBCL characterized by preferential intravascular growth malignant lymphocytes, aggressive behavior, and an often fatal course. IVLBCL usually affects elderly patients with poor performance status, elevated lactic dehydrogenase serum levels, anemia, B symptoms. It displays some differences in clinical presentation among diverse geographical areas, mostly between diagnosed Western countries Japan. In addition, data from the...
Mantle cell lymphoma (MCL) is typically a very aggressive disease with poor outcomes, but some cases display an indolent behavior that might not necessitate treatment at diagnosis. To define molecular criteria permit recognition of such cases, we compared the clinicopathologic features, gene expression, and genomic profile patients who had or conventional (iMCL cMCL). Patients iMCL displayed nonnodal leukemic predominantly hypermutated IGVH noncomplex karyotypes. cMCL shared common...
Cryostat sections from lymph nodes of 47 Hodgkin disease patients were examined by immunohistology for the Epstein-Barr virus (EBV)-encoded latent membrane protein (LMP), nuclear antigen 2, and late viral glycoprotein gp350/250. A distinct LMP-specific cytoplasmic staining was detected exclusively in Reed-Sternberg cells 18 (38%); EBV 2 gp350/250 immunoreactivity absent all instances. Thirty-two (68%) cases contained EBV-specific DNA sequences as PCR, LMP-positive being this category. Our...
The tumor microenvironment is important for the behavior of cancer. We assessed distribution and biological significance FOXP3(+) regulatory T-cells (Treg) in lymphomas.The absolute number intratumoral cells was immunohistochemically studied on lymphoma tissue microarrays from 1019 cases different types lymphomas correlated to phenotypic clinical parameters uni- multivariate models. Receiver operating characteristic -curves were used determine prognostic cut-off values cell density.Of cases,...