A5088017373- Renal Diseases and Glomerulopathies
- Cytomegalovirus and herpesvirus research
- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Complement system in diseases
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Diabetes Treatment and Management
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- T-cell and B-cell Immunology
- Diabetes and associated disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Systemic Sclerosis and Related Diseases
- Metabolism and Genetic Disorders
- Autoimmune Bullous Skin Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Muscle and Compartmental Disorders
- Immune Cell Function and Interaction
- Potassium and Related Disorders
- Liver Disease and Transplantation
- Salmonella and Campylobacter epidemiology
- Atherosclerosis and Cardiovascular Diseases
- Transplantation: Methods and Outcomes
- Platelet Disorders and Treatments
- Polyomavirus and related diseases
Inserm
2015-2024
Centre Hospitalier Universitaire de Besançon
2015-2024
Université de franche-comté
2013-2024
Centre Hospitalier Universitaire Amiens-Picardie
2024
Metabolism and Renal Physiology
2023
Établissement Français du Sang
2023
Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
2015-2021
Université Bourgogne Franche-Comté
2016-2021
Université de Bourgogne
2021
Structure Fédérative de Recherche en Biologie et Santé de Rennes
2015-2020
Abstract Background Patients with chronic kidney disease (CKD) are more prone to develop premature age-related diseases. Data on immune senescence scarce in CKD populations, except end-stage renal and dialysis. We designed a longitudinal prospective study evaluate at different stages its influence patient outcomes. Methods Clinical biological data collections were performed 222 patients [1–2 (n = 85), 4 53) 5 84)]. Immune biomarkers measured by cytometry T cells (CD28, CD57, CD45RA, CD31,...
Persistent ATG-induced CD4+ T cell lymphopenia is associated with serious clinical complications. We tested the hypothesis that ATG induces accelerated immune senescence in renal transplant recipients (RTR). Immune biomarkers were analyzed at and one-year later 97 incident RTR −62 patients receiving 35 anti-CD25 mAb (α-CD25). This consisted in: (i) thymic output; (ii) bone marrow renewal of CD34+ hematopoietic progenitor cells (CD34+HPC) lymphoid (l-HPC) myeloid (m-HPC) ratio; (iii)...
Background Previous small studies have reported favorable results of peritoneal dialysis (PD) in the setting chronic refractory heart failure (CRHF). We evaluated impact PD a larger cohort patients with CHRF where end-stage renal disease was excluded. Methods All who received therapy for CRHF between January 1995 and December 2010 two medical centers France were included this retrospective study. Baseline characteristics compared clinical parameters during first year after initiation PD....
End-stage renal disease (ESRD) causes premature ageing of the immune system. However, it is not known whether hemodialysis (HD) and peritoneal dialysis (PD) similarly affect T cell system.The aim our study was to analyse modality may mitigate ESRD-induced senescence. We explored a large population patients (675 ESRD patients) both confirmed refined results in second cohort (84 patients).HD exhibited higher inflammatory monocytes counts (44/mm3 (1-520) vs 36/mm3 (1-161); p = 0.005). Patients...
The phospholipase A2 receptor (PLA2R1) is the major autoantigen in idiopathic membranous nephropathy (MN). However, pathogenic role of anti-PLA2R1 autoantibodies unclear. Our aim was to evaluate vitro cytotoxicity antibodies mediated by complement. Forty-eight patients with PLA2R1-related MN from prospective cohort SOURIS were included. Anti-PLA2R1 titer, epitope profile, and IgG subclasses characterized ELISA. Cell evaluated immunofluorescence HEK293 cells overexpressing PLA2R1 incubated...
Abstract Background End‐stage renal disease ( ESRD ) is associated with premature aging of the T‐cell system. Nevertheless, clinical significance pre‐transplant ‐related immune senescence unknown. Methods We studied whether risk phenotype IRP ), a typical feature senescence, may affect post‐transplant infectious complications. A total 486 patients were prospectively during first year post transplant. was defined as positive cytomegalovirus serology at least 1 following criteria: CD 4/ 8...
Primary membranous nephropathy (pMN) is an autoimmune kidney disease and a common cause of nephrotic syndrome in adults. Rituximab becoming first line therapy for patients with persistent proven safety efficacy, achieving remission 60%–80% cases. For the remaining 20%–40% there urgent need to identify early biomarkers resistance rituximab adapt therapeutic management. In patients, found blood more transiently than other diseases without proteinuria, due wasting urine. However,...
Abstract Background Non-tunneled hemodialysis catheters are currently used for critically ill patients with acute kidney injury requiring extracorporeal renal replacement therapy. Strategies to prevent catheter dysfunction and infection locks remain controversial. Methods In a multicenter, randomized, controlled, double-blind trial, we compared two strategies locking of non-tunneled catheters, namely trisodium citrate at 4% (intervention group) versus unfractionated heparin (control group),...
Rituximab is a first-line treatment for membranous nephropathy. Nephrotic syndrome limits rituximab exposure due to urinary drug loss. underdosing (serum level <2 μg/ml at month-3) risk factor failure. We developed machine learning algorithm predict the of based on patients' characteristics infusion. investigated relationship between predicted and cumulative dose required achieve remission.
T-lymphocyte activation may contribute to atherosclerosis, the prevalence of which is increased in transplant patients. However, cardiovascular consequences polyclonal antithymocyte globulin (ATG)-induced immune modifications, include alterations T-cell subsets, are unknown. We conducted a retrospective single-center study assess whether ATG associates with an incidence atherosclerotic events (CVEs) kidney Propensity score analysis was performed address potential confounding by indication....
Although the MEST-C classification is among best prognostic tools in immunoglobulin A nephropathy (IgAN), it has a wide interobserver variability between specialized pathologists and others. Therefore we trained evaluated tool using neural network to automate grading.Biopsies of patients with IgAN were divided into three independent groups: Training cohort (n = 42) train network, Test 66) compare its pixel segmentation that made by Application 88) scores computed or pathologists.In cohort,...
<h3>Background</h3> The PEXIVAS (Plasma exchange and glucocorticoids in severe antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis) trial showed that a reduced-dose glucocorticoid regimen (redGC) was non-inferior to standard-dose (standGC) with respect death or end-stage kidney disease (ESKD) patients ANCA-associated vasculitis (AAV). However, the primary endpoint did not include progression relapse, cyclophosphamide main induction therapy rituximab (RTX)-treated tended have...
Lack of clear identification patients at high risk acute rejection hampers the ability to individualize immunosuppressive therapy. Here we studied whether thymic function may predict in antithymocyte globulin (ATG)-treated renal transplant recipients 482 prospectively during first year post-transplant which 86 experienced rejection. Only CD45RA(+)CD31(+)CD4(+) T cell (recent emigrant [RTE]) frequency (RTE%) was marginally associated with whole population. This T-cell subset accounts for 26%...
The prognosis of patients undergoing kidney tumor resection or donation is linked to many histologic criteria. These criteria notably include glomerular density, volume, vascular luminal stenosis, and severity interstitial fibrosis/tubular atrophy. Automated measurements through a deep-learning approach could save time provide more precise data. This work aimed develop free tool automatically obtain prognostic features.In total, 241 samples healthy tissue were split into three independent...
Immune checkpoint inhibitors (ICIs) dramatically improve the prognosis of many malignancies but at cost numerous side effects, which may limit their benefits. Acute kidney injury associated with immune most frequently are acute tubulointerstitial nephritis (ATIN), various cases glomerulonephritis have also been reported. Herein, we report a case severe IgA nephropathy (IgAN) ICIs and carry out literature review. IgAN was diagnosed in median time 5 months (range 1-12 months) after initiation...
Cryptococcosis is the third most common cause of invasive fungal infection in solid organ transplant recipients and cryptococcal meningitis (CM) its main clinical presentation. CM outcomes, as well features radiological characteristics, have not yet been considered on a large scale context kidney transplantation (KT). We performed nationwide retrospective study adult patients diagnosed with cryptococcosis after KT between 2002 2020 across 30 centers France. sought to describe overall graft...
Abstract Background Infection-related glomerulonephritis with IgA deposits (IRGN-IgA) is a rare disease but it increasingly reported in the literature. Data regarding epidemiology and outcome are lacking, especially Europe. We aimed to assess clinical, pathologic data of IRGN-IgA. Methods Clinical from patients 11 French centers over 2007–2017 period were collected retrospectively. reviewed patterns immunofluorescence renal biopsies evaluated C4d expression analyzed correlation between...
ABSTRACT Background Interstitial inflammation and peritubular capillaritis are observed in many diseases on native transplant kidney biopsies. A precise automated evaluation of these histological criteria could help stratify patients’ prognoses facilitate therapeutic management. Methods We used a convolutional neural network to evaluate those total 423 samples from various were included; 83 for the training, 106 comparing manual annotations limited areas predictions, 234 compare visual...
Accelerated thymic involution is a main feature of end-stage renal disease (ESRD)-associated immune senescence. Recent evidences suggest that ESRD-associated senescence associated with adverse outcomes in dialysis patients. However, no study focused on the association between pre-transplant function and patient survival after transplantation. We conducted prospective, multicenter to assess whether measured by recent emigrants (RTE) may predict death first kidney Results were tested...
In Brief Background Chronic exposure to exogenous antigens causes accumulation of proinflammatory CD57+CD28− hyperactivated CD8+ T cells that may promote atherosclerosis. We hypothesized persistent alloimmune responses induce immune activation and contribute posttransplant Methods This hypothesis was tested in a single-center cohort 577 kidney transplant patients. Propensity score analysis performed address potential confounding variables by indication. Immune exhaustion studied subcohort...
Abstract Background Acute kidney injury (AKI) is still characterized by a high mortality rate. While most patients with AKI are admitted in conventional medical units, current available data obtained from studies designed for intensive care units (ICU). Our study aimed to elaborate and validate an in-hospital death prognosis score units. Methods We included two prospective cohorts of consecutive between 2001 2004 (elaboration cohort (EC)) 2010 2014 (validation (VC)). developed scoring system...