A5001499463- Renal Diseases and Glomerulopathies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Complement system in diseases
- COVID-19 Impact on Reproduction
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood groups and transfusion
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Systemic Sclerosis and Related Diseases
- Chronic Kidney Disease and Diabetes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Abdominal vascular conditions and treatments
- Drug-Induced Hepatotoxicity and Protection
- Chronic Lymphocytic Leukemia Research
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Platelet Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Folate and B Vitamins Research
- Vaccine Coverage and Hesitancy
- Epigenetics and DNA Methylation
- Dialysis and Renal Disease Management
- Hemoglobinopathies and Related Disorders
- Intramuscular injections and effects
- Infectious Disease Case Reports and Treatments
Centre Hospitalier Universitaire de Besançon
2020-2024
Inserm
2021-2024
Université de franche-comté
2024
Établissement Français du Sang
2023
Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
2021
Centre de Recherche des Cordeliers
2021
Université Paris Cité
2021
Sorbonne Université
2021
Hôpital Européen
2020
Assistance Publique – Hôpitaux de Paris
2020
We report a case of kidney transplant recipient who presented with acute injury and nephrotic-range proteinuria in context severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Kidney biopsy revealed collapsing glomerulopathy. Droplet-based digital polymerase chain reaction did not detect the presence SARS-CoV-2 RNA fragment, virus was barely detectable plasma at time biopsy. RNAemia peaked several days later, followed by seroconversion despite absence circulating CD19-positive...
Kidney transplant recipients (KTRs) are prone to develop severe COVID-19 and less well protected by vaccine than immunocompetent subjects. Thus, the use of neutralizing anti-SARS-CoV-2 monoclonal antibody (MoAb) confer a passive immunity appears attractive in KTRs.We performed French nationwide study compare COVID-19-related hospitalization, 30-day admission intensive care unit (ICU), death between KTRs who received an early infusion MoAb (MoAb group) did not (control group). Controls were...
Although the MEST-C classification is among best prognostic tools in immunoglobulin A nephropathy (IgAN), it has a wide interobserver variability between specialized pathologists and others. Therefore we trained evaluated tool using neural network to automate grading.Biopsies of patients with IgAN were divided into three independent groups: Training cohort (n = 42) train network, Test 66) compare its pixel segmentation that made by Application 88) scores computed or pathologists.In cohort,...
Immune checkpoint inhibitors (ICIs) dramatically improve the prognosis of many malignancies but at cost numerous side effects, which may limit their benefits. Acute kidney injury associated with immune most frequently are acute tubulointerstitial nephritis (ATIN), various cases glomerulonephritis have also been reported. Herein, we report a case severe IgA nephropathy (IgAN) ICIs and carry out literature review. IgAN was diagnosed in median time 5 months (range 1-12 months) after initiation...
ABSTRACT Background Interstitial inflammation and peritubular capillaritis are observed in many diseases on native transplant kidney biopsies. A precise automated evaluation of these histological criteria could help stratify patients’ prognoses facilitate therapeutic management. Methods We used a convolutional neural network to evaluate those total 423 samples from various were included; 83 for the training, 106 comparing manual annotations limited areas predictions, 234 compare visual...
Kidney transplant recipients (KTRs) have an increased risk of cardiovascular (CV) events (CVEs) compared with the general population. The impact insulin resistance on CV after transplantation is not well defined.We tested whether triglyceride-glucose (TyG) index, a surrogate marker resistance, may predict posttransplant CVEs in cohort 715 consecutive KTRs all included 1 year transplant.Follow-up was 9.1 ± 4.6 years. Mean TyG at inclusion 4.75 0.29 (median, 4.73 [4.14-5.84]). In multiple...