Melchior Chabannes

ORCID: 0009-0006-2037-8096
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About
Contact & Profiles
Research Areas
  • Renal Diseases and Glomerulopathies
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Complement system in diseases
  • COVID-19 Impact on Reproduction
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Blood groups and transfusion
  • Amyloidosis: Diagnosis, Treatment, Outcomes
  • Systemic Sclerosis and Related Diseases
  • Chronic Kidney Disease and Diabetes
  • Heparin-Induced Thrombocytopenia and Thrombosis
  • Abdominal vascular conditions and treatments
  • Drug-Induced Hepatotoxicity and Protection
  • Chronic Lymphocytic Leukemia Research
  • Liver Disease and Transplantation
  • Organ Transplantation Techniques and Outcomes
  • Platelet Disorders and Treatments
  • Cancer Immunotherapy and Biomarkers
  • Folate and B Vitamins Research
  • Vaccine Coverage and Hesitancy
  • Epigenetics and DNA Methylation
  • Dialysis and Renal Disease Management
  • Hemoglobinopathies and Related Disorders
  • Intramuscular injections and effects
  • Infectious Disease Case Reports and Treatments

Centre Hospitalier Universitaire de Besançon
2020-2024

Inserm
2021-2024

Université de franche-comté
2024

Établissement Français du Sang
2023

Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine
2021

Centre de Recherche des Cordeliers
2021

Université Paris Cité
2021

Sorbonne Université
2021

Hôpital Européen
2020

Assistance Publique – Hôpitaux de Paris
2020

We report a case of kidney transplant recipient who presented with acute injury and nephrotic-range proteinuria in context severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Kidney biopsy revealed collapsing glomerulopathy. Droplet-based digital polymerase chain reaction did not detect the presence SARS-CoV-2 RNA fragment, virus was barely detectable plasma at time biopsy. RNAemia peaked several days later, followed by seroconversion despite absence circulating CD19-positive...

10.1053/j.ajkd.2020.06.009 article EN publisher-specific-oa American Journal of Kidney Diseases 2020-07-12

Kidney transplant recipients (KTRs) are prone to develop severe COVID-19 and less well protected by vaccine than immunocompetent subjects. Thus, the use of neutralizing anti-SARS-CoV-2 monoclonal antibody (MoAb) confer a passive immunity appears attractive in KTRs.We performed French nationwide study compare COVID-19-related hospitalization, 30-day admission intensive care unit (ICU), death between KTRs who received an early infusion MoAb (MoAb group) did not (control group). Controls were...

10.1016/j.ekir.2022.03.020 article EN cc-by Kidney International Reports 2022-03-26

Although the MEST-C classification is among best prognostic tools in immunoglobulin A nephropathy (IgAN), it has a wide interobserver variability between specialized pathologists and others. Therefore we trained evaluated tool using neural network to automate grading.Biopsies of patients with IgAN were divided into three independent groups: Training cohort (n = 42) train network, Test 66) compare its pixel segmentation that made by Application 88) scores computed or pathologists.In cohort,...

10.1093/ndt/gfad039 article EN Nephrology Dialysis Transplantation 2023-02-15

Immune checkpoint inhibitors (ICIs) dramatically improve the prognosis of many malignancies but at cost numerous side effects, which may limit their benefits. Acute kidney injury associated with immune most frequently are acute tubulointerstitial nephritis (ATIN), various cases glomerulonephritis have also been reported. Herein, we report a case severe IgA nephropathy (IgAN) ICIs and carry out literature review. IgAN was diagnosed in median time 5 months (range 1-12 months) after initiation...

10.3389/fimmu.2024.1393901 article EN cc-by Frontiers in Immunology 2024-05-14

ABSTRACT Background Interstitial inflammation and peritubular capillaritis are observed in many diseases on native transplant kidney biopsies. A precise automated evaluation of these histological criteria could help stratify patients’ prognoses facilitate therapeutic management. Methods We used a convolutional neural network to evaluate those total 423 samples from various were included; 83 for the training, 106 comparing manual annotations limited areas predictions, 234 compare visual...

10.1093/ndt/gfad094 article EN Nephrology Dialysis Transplantation 2023-05-17

Kidney transplant recipients (KTRs) have an increased risk of cardiovascular (CV) events (CVEs) compared with the general population. The impact insulin resistance on CV after transplantation is not well defined.We tested whether triglyceride-glucose (TyG) index, a surrogate marker resistance, may predict posttransplant CVEs in cohort 715 consecutive KTRs all included 1 year transplant.Follow-up was 9.1 ± 4.6 years. Mean TyG at inclusion 4.75 0.29 (median, 4.73 [4.14-5.84]). In multiple...

10.1016/j.ekir.2023.08.021 article EN cc-by Kidney International Reports 2023-08-24
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