A5040406554- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Sepsis Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Complement system in diseases
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- Renal Transplantation Outcomes and Treatments
- Urticaria and Related Conditions
- Respiratory Support and Mechanisms
- Renal and Vascular Pathologies
- IgG4-Related and Inflammatory Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Dermatology and Skin Diseases
- Organ Donation and Transplantation
- Otitis Media and Relapsing Polychondritis
- Cardiovascular Function and Risk Factors
- Autoimmune Bullous Skin Diseases
Centre Hospitalier Universitaire Amiens-Picardie
2016-2025
Université de Picardie Jules Verne
2019-2025
Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires
2019-2024
Alberta Health Services
2022
University of Alberta
2022
Inserm
2017-2020
Centre de Recherche sur l'Inflammation
2017
University Medical Center
2016
Cardiac output (CO) monitoring is a valuable tool for the diagnosis and management of critically ill patients. In critical care setting, few studies have evaluated level agreement between CO estimated by transthoracic echocardiography (CO-TTE) that measured reference method, pulmonary artery catheter (CO-PAC). The objective present study was to evaluate precision accuracy CO-TTE relative CO-PAC ability track variations in CO, mechanically ventilated Thirty-eight patients fitted with PAC were...
Immunoreceptors can transduce either inhibitory or activatory signals depending on ligand avidity and phosphorylation status, which is modulated by the protein kinases Lyn Fyn. Here we show that Fyn control immune receptor signaling status. SHP-1 tyrosine 536 activates phosphatase promoting through immunoreceptor. By contrast, Fyn-dependent of serine 591 inactivates phosphatase, enabling immunoreceptor signaling. These signatures are relevant in vivo, as deficiency exacerbates nephritis...
The optimal management of thromboembolism (TE) in patients with nephrotic syndrome (NS) remains challenging. Until now, anticoagulation therapy for NS consisted vitamin K antagonists (VKAs) or heparin. Data on direct oral anticoagulant (DOAC) use are limited, and their safety convenience have been well-demonstrated other indications. We conducted a multicenter retrospective study adult treated therapeutic-dose between 2014 2022. compared the incidences bleeding TE events receiving DOAC those...
Although kidney transplantation carries a survival benefit compared with dialysis, mortality, especially the first year after transplantation, is high in recipients older than 70. The aim of this study was to evaluate early death and graft failure, determine risk factors associated these events specific population.
Data from the PEXIVAS trial challenged role of plasma exchange (PLEX) in ANCA-associated vasculitides (AAV). We aimed to describe kidney biopsy patients with AAV treated PLEX, evaluate whether histopathologic findings could predict function, and identify which would most benefit PLEX.We performed a multicenter, retrospective study on 188 AKI PLEX 237 not PLEX. The primary outcome was mortality or KRT at 12 months (M12).No significant for found. To benefitting we developed model predicting...
<h3>Importance</h3> Older patients are underrepresented in studies of rituximab for the treatment antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis. Little is known about outcomes and adverse events associated with use therapy among 75 years older ANCA-associated <h3>Objective</h3> To examine vasculitis, specifically granulomatosis polyangiitis (GPA) or microscopic (MPA). <h3>Design, Setting, Participants</h3> This multicenter cohort study involved 93 vasculitis from 36...
Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic small-vessel vasculitis characterized by asthma, hypereosinophilia and ANCA positivity in 40% of patients. Renal involvement rare poorly described, leading to this renal biopsy-proven based study large EGPA cohort.We conducted retrospective multicentre including patients fulfilling the 1990 ACR criteria and/or 2012 revised Chapel Hill Consensus Conference for modified MIRRA trial, nephropathy.Sixty-three [27 women, median age...
The risk of early death is particularly high in patients over the age 65 presenting with antineutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis. We hypothesized that by combining disease severity markers, a comorbidity index and serious adverse event reports, we would be able to identify predictors one-year mortality this population.We performed multicentre, retrospective study nephrology internal medicine departments six tertiary hospitals northern France. A total 149...
Background IgG4-related kidney disease is a major manifestation of disease, systemic fibroinflammatory disorder. However, the clinical and prognostic kidney-related factors in patients with are insufficiently defined. Methods We conducted an observational cohort study using data from 35 sites two European countries. Clinical, biologic, imaging, histopathologic data; treatment modalities; outcomes were collected medical records. Logistic regression was performed to identify possible related...
To examine whether the new urinary biomarkers TIMP2 and IGFBP7 can predict progression within 24 hours 72 from mild moderate (KDIGO 1 or 2) to severe 3) AKI in patients with septic shock. A prospective, multicenter observational study performed three French ICUs. The TIMP2∗IGFBP7 were analyzed at early phase (<6 hours) of admitted for shock AKI. Among 112 included, 45 (40%) progressed KDIGO 3 level after inclusion H24) 47 (42%) H72). median (baseline) higher group than KDIGO<3 H24 H72. All...
Abstract Objectives Urticarial vasculitis (UV) is characterized by atypical urticarial lesions and leukocytoclastic vasculitis, sometimes with extracutaneous manifestations. First-line treatment based on colchicine, hydroxychloroquine, dapsone or low-dose glucocorticoids. In refractory forms, the use of biologics has been anecdotally described as potentially effective. We aimed to describe efficacy safety in patients UV. Methods conducted a retrospective European multicentre study including...
Predicting the need for renal replacement therapy (RRT) in acute kidney injury (AKI) remains challenging. The utility of biomarkers was explored during previous studies which were biased as RRT indications relied on clinician opinion rather than evidence. Those preceded trials that clarified initiation criteria. We aimed to assess predicting criteria severe AKI patients. This is an ancillary study AKIKI2 trial. Patients with (stage 3) receiving invasive mechanical ventilation and/or...
Data for ANCA-associated vasculitis (AAV) patients requiring intensive care are scarce. We included 97 consecutive with acute AAV manifestations (new onset or relapsing disease), admitted to 18 units (ICUs) over a 10-year period (2002–2012). A group of 95 new disease, two nephrology departments manifestations, constituted the control group. In ICU group, predominantly showed granulomatosis polyangiitis and proteinase-3 ANCAs. Compared non-ICU comparable Birmingham activity score higher...
Background:Indoxyl sulfate (IS) is a protein-bound uremic toxin that known to be associated with the risk of cardiovascular (CV) disease and death in both predialysis dialysis patients. Data on levels toxins kidney transplant patients are scarce. The study's objective was evaluate IS relationship hard outcomes.Methods Results:In 311 patients, were measured immediately before transplantation (T0), 1 month (M1) 12 months (M12) afterwards. Over mean±standard deviation follow-up period 113±29...
High serum levels of gut-derived uremic toxins, especially p-cresyl sulfate (pCS), indoxyl (IS) and indole acetic acid (IAA), have been linked to adverse outcomes in patients with chronic kidney disease (CKD). Sevelamer carbonate could represent an interesting option limit the elevation toxins. The aim present study was evaluate adsorptive effect sevelamer on different protein-bound toxins or their precursors vitro, its impact pCS, IS IAA CKD stage 3b/4. For vitro experiments, IAA, p-cresol...
Background: Uremic toxins have emerged as potential mediators of morbidity and mortality in patients with chronic kidney disease (CKD). Indole-3-acetic acid (IAA, a tryptophan-derived uremic toxin) might be useful biomarker CKD. The objectives the present study were to (i) describe IAA concentrations cohort non-transplanted CKD transplanted CKD, (ii) investigate possible relationship between levels adverse outcomes two cohorts. Methods: Levels free total assayed prospective cohorts (140 311...
Abstract Background The urine biomarkers tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been validated for predicting stratifying AKI. In this study, we analyzed the utility these distinguishing between transient persistent AKI in early phase septic shock. Methods We performed a prospective, multicenter study 11 French ICUs. Patients presenting shock, with development within first 6 h, were included. Urine [TIMP-2]*[IGFBP7]...