A5054854271- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Kidney Stones and Urolithiasis Treatments
- Renal Transplantation Outcomes and Treatments
- Biomedical Research and Pathophysiology
- Porphyrin Metabolism and Disorders
- Long-Term Effects of COVID-19
- Polyomavirus and related diseases
- COVID-19 Impact on Reproduction
- Liver Disease and Transplantation
- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- COVID-19 and healthcare impacts
- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Neurological Complications and Syndromes
- Pancreatitis Pathology and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Pregnancy and Medication Impact
- Hepatitis C virus research
- Vasculitis and related conditions
- Diabetes Management and Research
- Muscle and Compartmental Disorders
- Transplantation: Methods and Outcomes
- Pancreatic function and diabetes
Cliniques Universitaires Saint-Luc
2015-2025
UCLouvain
2016-2024
Directorate-General Joint Research Centre
2021
PAX Scientific (United States)
2020
Assistance Publique – Hôpitaux de Paris
2018-2020
Hôpital Necker-Enfants Malades
2016-2018
Lumasiran reduces urinary and plasma oxalate (POx) in patients with primary hyperoxaluria type 1 (PH1) relatively preserved kidney function. ILLUMINATE-C evaluates the efficacy, safety, pharmacokinetics, pharmacodynamics of lumasiran PH1 advanced disease.
The urinary chemokines CXCL9 and CXCL10 are promising noninvasive diagnostic markers of acute rejection (AR) in kidney recipients, but their levels might be confounded by tract infection (UTI) BK virus (BKV) reactivation. Multiparametric model development validation addressed these confounding factors a training set 391 samples, optimizing the performance chemokines. CXCL9/creatinine increased UTI BKV viremia with or without nephropathy (BKVN) (no UTI/leukocyturia/UTI: -0.10/1.61/2.09, P =...
The world is facing a global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although kidney transplant recipients are at increased risk for viral infections, the impact of their chronic immunosuppressed status on acquiring disease 2019 (COVID-19) and severity unknown.All cases COVID-19 infection in our cohort were prospectively monitored. Clinical features, management, outcomes recorded. A standard strategy immunosuppression minimization was applied:...
Several reports of newly diagnosed or relapses immune-mediated renal diseases following vaccination with anti–severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA and AstraZeneca vaccines recently emerged in the litterature.1Morlidge C. El-Kateb S. Jeevaratnam P. Thompson B. Relapse minimal change disease COVID-19 vaccine.Kidney Int. 2021; 100: 459Abstract Full Text PDF PubMed Scopus (32) Google Scholar,2Masset Kervella D. Kandel-Aznar et al.Relapse IgG4-related nephritis...
Background IgG4-related kidney disease is a major manifestation of disease, systemic fibroinflammatory disorder. However, the clinical and prognostic kidney-related factors in patients with are insufficiently defined. Methods We conducted an observational cohort study using data from 35 sites two European countries. Clinical, biologic, imaging, histopathologic data; treatment modalities; outcomes were collected medical records. Logistic regression was performed to identify possible related...
Coronavirus disease 2019 , which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), particularly life threatening in patients who are immunocompromised, including those with advanced chronic kidney (CKD) [1,2].Despite the implementation of a third dose messenger RNA (mRNA) vaccine, efficacy SARS-CoV-2 vaccination on humoral and cellular immunities reduced population CKD, resulting an increased incidence infection mortality, fully vaccinated [3].In this context,...
Neutralizing monoclonal antibody treatments have shown promising preliminary results in kidney transplant recipients infected with severe acute respiratory syndrome coronavirus 2. However, their efficacy the Omicron variant has not been reported yet.Single-center retrospective study.We included all consecutive treated antibodies for 2 infections (positive polymerase chain reaction on nasopharyngeal swab) between June 10, 2021, and January 14, 2022. Forty-seven were included. All patients had...
Short bubble and subsequent surface oxygenation is an innovative technique alternative for membrane during hypothermic machine perfusion (HMP). The metabolic effect of the interruption 4 h (mimicking organ transport) HMP was compared to continuous in a pig kidney ex situ preservation model. After 30 min warm ischemia by vascular clamping, ±40 kg procured subsequently preserved according one following groups: (1) 22-h + intermittent (n = 12); (2) 6); (3) 7). Brief perfusate O2 uploading...
BK virus (BKV) replication increases urinary chemokine C-X-C motif ligand 10 (uCXCL10) levels in kidney transplant recipients (KTRs). Here, we investigated uCXCL10 across different stages of BKV as a prognostic and predictive marker for functional decline KTRs after BKV-DNAemia. was assessed cross-sectional study (474 paired urine/blood/biopsy samples longitudinal (1,184 from 60 with BKV-DNAemia). gradually increased urine (P-value < 0.0001) blood viral load (P 0.05) but were similar...
Recurrence of anti-glomerular basement membrane (anti-GBM) glomerulonephritis in the kidney graft is a rare event, described limited reports. The aim this study was to evaluate, large cohort patients with long follow-up, risk recurrence anti-GBM disease, factors associated clinical recurrence, and long-term patient survival.This multicenter retrospective study. Inclusion criteria were who underwent transplantation between 1977 2015. Exclusion systemic vasculitis, lupus erythematosus,...
Evidence regarding the role of cellular immunity in protecting against COVID-19 is emerging. To better assess immune status, simple and robust assays measuring specific T-cell responses associated with humoral are needed. We aimed to evaluate Quan-T-Cell SARS-CoV-2 test for vaccinated healthy immunosuppressed subjects.
The first wave of coronavirus disease 2019 (COVID-19) was particularly dramatic for kidney transplant recipients (KTRs) around the world.1 A recent European registry study showed 28-day mortality and intensive care unit (ICU) admission rates at 22% 21%, respectively.2 In United States, a multicenter cohort revealed rate 18%.3 Fortunately, patients from our tertiary KT center were less impacted with ICU 11% 11%, respectively.4 Like many countries, Belgium is currently facing its COVID-19...
Tobacco smoking is a frequent problem affecting many kidney transplant (KT) candidates and recipients. The negative impact of active on KT outcomes has been demonstrated. Consequently, most guidelines strongly recommend quitting before considering transplantation. However, nicotine addiction complex multifactorial disease only 3-5% the patients who try to quit by themselves achieve prolonged abstinence. Smoking cessation programmes (SCPs) have proven their efficacy in general population...
Background and aims Human islet preparations designated for research exhibit diverse insulin-secretory profiles. This study to assess the impact of donor- isolation-related factors on in vitro secretory function. Methods A retrospective analysis 46 isolations from 23 pancreata discarded clinical transplantation was conducted. In function tests were performed Day 1 7 culture. Linear mixed-effects models (LMMs) employed investigate relationships between various predictors characterizing...
Direct-acting antivirals (DAAs) have revolutionized the treatment of hepatitis C virus (HCV) infection. Although previous studies reported positive results with DAAs after kidney transplantation (KT), their impact on prevalence HCV viremia (HCVv) in prevalent transplant recipients (KTRs) remains ill defined. We retrospectively reviewed status all patients followed at Cliniques Universitaires Saint-Luc, Brussels, Belgium, outpatient KT clinic between January 2014 and December 2018. collected...