A5052974303- Renal Diseases and Glomerulopathies
- Calpain Protease Function and Regulation
- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Electrolyte and hormonal disorders
- Mast cells and histamine
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Ion Transport and Channel Regulation
- Cell Adhesion Molecules Research
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Vasculitis and related conditions
- IgG4-Related and Inflammatory Diseases
- Immune Cell Function and Interaction
- Neurological and metabolic disorders
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Pregnancy and Medication Impact
- Kidney Stones and Urolithiasis Treatments
- Toxoplasma gondii Research Studies
- Urticaria and Related Conditions
- Venomous Animal Envenomation and Studies
- Pediatric Urology and Nephrology Studies
- Nerve injury and regeneration
- Invertebrate Immune Response Mechanisms
Université Paris Cité
2013-2024
Assistance Publique – Hôpitaux de Paris
2013-2024
Hôpital Bichat-Claude-Bernard
2017-2024
Délégation Paris 7
2017-2024
Université Claude Bernard Lyon 1
2017-2024
Centre de Recherche sur l'Inflammation
2019-2024
Centre National de la Recherche Scientifique
2019-2023
Inserm
2013-2023
Hôpital Tenon
2014-2022
Sorbonne Université
2011-2022
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by anti-nuclear autoantibodies whose production promoted autoreactive T follicular helper (TFH) cells. During SLE pathogenesis, basophils accumulate in secondary lymphoid organs (SLO), amplify autoantibody and progression through mechanisms that remain to be defined. Here, we provide evidence for a direct functional relationship between TFH cells during both humans mice. PD-L1 upregulation on IL-4 are...
Catastrophic antiphospholipid syndrome (CAPS) is a life-threatening disease caused by the onset of rapidly progressive and widespread small-vessel thromboses in presence aPLs. The aim this study was to examine pregnancy-related CAPS.Retrospective series 13 patients with CAPS special focus on follow-up. RESULTS; Eleven had known APS been treated low-molecular-weight heparin (n = 10), aspirin 8), oral anticoagulants 1), HCQ 3) and/or steroids 1) during pregnancy. most frequent manifestations...
Background IgG4-related kidney disease is a major manifestation of disease, systemic fibroinflammatory disorder. However, the clinical and prognostic kidney-related factors in patients with are insufficiently defined. Methods We conducted an observational cohort study using data from 35 sites two European countries. Clinical, biologic, imaging, histopathologic data; treatment modalities; outcomes were collected medical records. Logistic regression was performed to identify possible related...
Conventional calpains are ubiquitous cysteine proteases whose activity is promoted by calcium signaling and specifically limited calpastatin. Calpain expression has been shown to be increased in human malignant cells, but the contribution of calpain/calpastatin system tumorigenesis remains unclear. It may play an important role tumor cells themselves (cell growth, migration, a contrario cell death) and/or niche (tissue infiltration immune neo-angiogenesis). In this study, we have used mouse...
Antidiuretic hormone or arginine vasopressin (AVP) increases water reabsorption in the collecting ducts of kidney. Three decades ago, experimental models have shown that AVP may increase calcium rat The objective this study was to assess whether modulates renal excretion humans. We analyzed calcium, potassium, and sodium fractional eight patients affected by insipidus diabetes (nephrogenic central) under acute receptor agonist action 10 undergoing oral load test not inappropriate...
Background: Lupus nephritis (LN) is a severe manifestation of Systemic Erythematosus (SLE). The therapeutic strategy relies on kidney biopsy (KB) results. We tested whether urinary peptidome analysis could non-invasively differentiate active from non-active LN. Design: Urinary samples were collected 93 patients (55 with LN and 38 LN), forming discovery (n = 42) an independent validation 51) cohort. Clinical characteristics at inclusion prospectively for 24 months. was analyzed by...
Abstract Calpains are ubiquitous pro-inflammatory proteases, whose activity is controlled by calpastatin, their specific inhibitor. Transgenic mice over-expressing rabbit calpastatin (CalpTG) protected against vascular remodelling and angiotensin II-dependent inflammation. We hypothesized that calpain inhibition would protect aging-related lesions in arteries kidneys. analysed tissues from 2-months 2-years-old CalpTG wild-type performed high throughput RNA-Sequencing of kidney tissue aged...
Abstract Objective The optimal induction therapy for severe glomerulonephritis of ANCA-associated vasculitis (AAV) is debated. We compared the efficacy glucocorticoid and rituximab (RTX) or CYC AAV-related evaluated potential benefit plasma exchange (PE) as adjunct to CYC. Methods This retrospective, multicentre study included AAV patients with renal active disease (serum creatinine level ≥350 µmol/l and/or estimated glomerular filtration ratio ≤15 ml/min/1.73 m2). Propensity-score analysis...
Basophils were recently shown to contribute lupus nephritis (LN). This study assessed blood basophil activation markers (BAMs) for the diagnosis of LN severity and as pre-treatment prognostic response treatment in patients with severe LN.The diagnostic included all a monocentric prospective observational cohort built consecutive diagnosed on basis renal biopsy. The selected this according following inclusion criteria: ≥18 years old, Class III or IV A ± C V pure at time treated an induction...
A 46-year-old patient was referred to our unit with acute renal failure, his serum creatinine having risen from 137 431 μmol/l in eight months. He born the Republic of Congo and had lived France since 2009. no significant previous medical history. On admission, clinical examination normal except for high blood pressure. Blood analyses confirmed impairment. Urine were proteinuria (urinary protein ratio 1 g/g), haematuria (105 red cells/ml) leucocyturia (104 white cells/ml). Serum...
The burden of kidney disease has been growing steadily throughout the world. It is estimated that around 2 million patients, most whom live in low and lower-middle income countries, reach end-stage (ESKD) annually, this anticipated to worsen coming years.1–3 Kidney replacement therapy (KRT) requires highly technical equipment expertise, which are costly. As a consequence, KRT very unevenly distributed worldwide.4 management undocumented immigrants suffering from ESKD without medical...
ABSTRACT Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibodies raised against nuclear antigens and whose production promoted autoreactive T follicular helper (TFH) cells. Basophils, accumulating in secondary lymphoid organs (SLO), amplify autoantibody progression through mechanisms to be defined. Here, we demonstrate that a functional relationship between TFH cells basophils occurs SLO during pathogenesis. On SLE patient blood basophils, PD-L1 expression...
Abstract Background and Aims Lupus nephritis (LN) is a frequent manifestation of Systemic Erythematosus (SLE). The therapeutic strategy relies on the result kidney biopsy, which differentiates proliferative LN (PLN) from non-proliferative (NPLN). analysis urinary peptidome has led to identification prognostic biomarkers in chronic disease (CKD, namely CKD273 classifier), or, as liquid for diagnosis glomerulonephritides. We verified whether peptidomics could predict severity renal...