A5072750770- Nutrition and Health in Aging
- Muscle metabolism and nutrition
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Diet and metabolism studies
- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism and Genetic Disorders
- Parathyroid Disorders and Treatments
- Muscle Physiology and Disorders
- Telomeres, Telomerase, and Senescence
- Renal and Vascular Pathologies
- COVID-19 Clinical Research Studies
- Polyomavirus and related diseases
- Potassium and Related Disorders
- Birth, Development, and Health
- Muscle and Compartmental Disorders
- Acute Kidney Injury Research
- Liver Disease and Transplantation
- Inflammasome and immune disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Blood groups and transfusion
- Long-Term Effects of COVID-19
Ospedale Policlinico San Martino
2017-2024
University of Genoa
2017-2024
Casa di Cura Villa Garda
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2023
Jackson and Tull (United States)
2023
Assistance Publique – Hôpitaux de Paris
2020
RELX Group (United States)
2019
The mechanisms by which hyperuricemia induces vascular dysfunction and contributes to cardiovascular disease are still debated. Phenotypic transition is a property of smooth muscle cells (VSMCs) involved in organ damage. aim this study was investigate the effects uric acid (UA) on changes VSMC cytoskeleton, cell migration signals these processes. MOVAS, mouse line, incubated with 6, 9 12 mg/dL UA, angiotensin receptor blockers (ARBs), proteasome MEK-inhibitors. Migration assessed...
Indoxyl sulfate (IS) accumulation occurs early during chronic kidney disease (CKD) progression and contributes to renal dysfunction by inducing fibrosis, inflammation, oxidative stress, tissue remodeling. Renal toxicity of high IS concentrations (250 μ M) has been widely explored, particularly in resident tubular glomerular cells, while the effect a moderate increase on kidneys is still mostly unknown. To define effects fibroblasts, we first analyzed C57BL/6 mice receiving (0.1%) drinking...
To evaluate the impact of Coronavirus Disease-19 (COVID-19) pandemic on epidemiology acute kidney injury (AKI) in hospitalized patients, we performed a retrospective cohort study comparing data patients from January 2016 to December 2019 (pre-COVID-19 period) and 2020 (COVID-19 period, including both severe respiratory syndrome coronavirus 2 (SARS-CoV-2)-negative positive patients). AKI was classified by evaluating kinetics creatinine levels. A total 51,681 during pre-COVID-19 period 10,062...
Early studies have shown that patients with chronic kidney disease (CKD) are able to maintain nitrogen balance despite significantly lower protein intake, but how and what extent muscle metabolism adapts a low-protein diet (LPD) or supplemented very LPD (sVLPD) is still unexplored.We studied turnover by the forearm perfusion method associated kinetics of 2H-phenylalanine in CKD: (i) parallel study subjects randomized usual (1.1 g protein/kg, n = 5) (0.55 6) (Protocol 1); (ii) crossover,...
Although heart failure is the most prevalent cardiovascular disease associated with adverse outcome in chronic kidney (CKD) and after transplantation, left ventricular (LV) systolic function often preserved renal patients. The aim of this study was to evaluate global longitudinal strain (GLS), which reportedly a more accurate tool for detecting subclinical LV dysfunction, patients various degrees impairment, including transplant recipients (KTRs).This prospective evaluated demographic,...
Myostatin (MSTN), a family member of the transforming growth factor (TGF)-β super family, has been detected in tubuli pig kidney, but its role human kidney is not known. In this study we observed upregulation MSTN mRNA (~8 to 10-fold increase) both glomeruli and tubulointerstitium diabetic nephropathy (DN). DN, immunoreactive was mainly localized interstitium (∼4-8 fold increase), where it colocalized CD45+ cells. also upregulated arterial vessels. Tubulointerstitial expression directly...
Cellular senescence has emerged as an important driver of aging and age-related disease in the kidney. The activity β-galactosidase at pH 6 (SA-β-Gal) is a classic maker cellular biology; however, predictive role kidney tissue SA-β-Gal on eGFR loss chronic (CKD) still not understood. We retrospectively studied expression biopsies obtained cohort [n = 22] incident patients who were followed up for 3 years standard care. staining was approximately fourfold higher tubular compartment with CKD...
The predictive role of blood pressure variability for all-cause mortality and fatal nonfatal cardiovascular events has been described in the general population patients with diabetes, independently mean BP. Although systolic proposed as an informative measure predicting clinical outcomes chronic kidney disease, its transplant recipients is still debatable.
<b><i>Background:</i></b> Chronic kidney disease (CKD) reduces both Klotho expression and its shedding into circulation, an effect that accelerates progression cardiovascular complications. However, the mechanisms regulate release by human are still unknown. <b><i>Methods:</i></b> We measured plasma across kidney, splanchnic organs lung in 22 patients (71 ± 2 years, estimated glomerular filtration rate [eGFR] 60 5.4 mL/min 1.73...
Antihypertensive treatment by the use of RAAS inhibitors (RAAS-is) is paramount importance in management slowly progressive IgA nephropathy (IgAN). With aim better understanding relationship between BP behavior and progression, we looked at time-averaged SBP proteinuria renal outcome a single-center cohort IgAN patients.Among 248 consecutive patients referred to Clinic Nephrology San Martino Hospital from 1996 2018 for native biopsy with diagnosis IgAN, retrospectively analyzed 145 available...
BK virus (BKV) replication increases urinary chemokine C-X-C motif ligand 10 (uCXCL10) levels in kidney transplant recipients (KTRs). Here, we investigated uCXCL10 across different stages of BKV as a prognostic and predictive marker for functional decline KTRs after BKV-DNAemia. was assessed cross-sectional study (474 paired urine/blood/biopsy samples longitudinal (1,184 from 60 with BKV-DNAemia). gradually increased urine (P-value &lt; 0.0001) blood viral load (P 0.05) but were similar...
<b><i>Background:</i></b> A current, albeit unproven, hypothesis is that an acceleration of cellular senescence involved in impaired renal repair and progression glomerular diseases. Focal segmental glomerulosclerosis (FSGS) a disease with substantial risk for to ESRD. However, if what extent cell predicts negative outcome FSGS still unknown. <b><i>Methods:</i></b> The represents proximate mechanism by which the kidney damaged (NOS phenotype)...