A5010824761- Cardiovascular Health and Disease Prevention
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Radiomics and Machine Learning in Medical Imaging
- Renal and Vascular Pathologies
- Elasticity and Material Modeling
- Cerebrovascular and Carotid Artery Diseases
- Dialysis and Renal Disease Management
- Advanced Radiotherapy Techniques
- Renal Transplantation Outcomes and Treatments
- Blood Pressure and Hypertension Studies
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Connective tissue disorders research
- Platelet Disorders and Treatments
- Prostate Cancer Treatment and Research
- Botulinum Toxin and Related Neurological Disorders
- Prostate Cancer Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Hemodynamic Monitoring and Therapy
- Cerebral Palsy and Movement Disorders
- AI in cancer detection
- Organ Donation and Transplantation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Colorectal Cancer Surgical Treatments
Centre Hospitalier Universitaire de Saint-Étienne
2011-2025
Centre Eugène Marquis
2023-2024
Inserm
2007-2023
Université Jean Monnet
2011-2023
Hôpital Nord
2012-2023
Université Claude Bernard Lyon 1
2012-2023
Université Paris Cité
2008-2023
Centre International de Recherche en Infectiologie
2023
Assistance Publique – Hôpitaux de Paris
2023
Institut de Cancérologie de l'Ouest
2018-2022
Abstract Multicenter studies are needed to demonstrate the clinical potential value of radiomics as a prognostic tool. However, variability in scanner models, acquisition protocols and reconstruction settings unavoidable radiomic features notoriously sensitive these factors, which hinders pooling them statistical analysis. A harmonization method called ComBat was developed deal with “batch effect” gene expression microarray data used “center-effect”. Our goal evaluate modifications allowing...
The aim of this retrospective multicentric study was to develop and evaluate a prognostic <sup>18</sup>F-FDG PET/CT radiomic signature in early-stage non–small cell lung cancer patients treated with stereotactic body radiotherapy (SBRT). <b>Methods:</b> Patients from 3 different centers (<i>n</i> = 27, 29, 8) were pooled constitute the training set, whereas fourth center 23) used as testing set. primary endpoint local control. tumor semiautomatically delineated PET images using fuzzy locally...
Abstract Objective To compare the performance of a newly developed race-free kidney recipient specific glomerular filtration rate (GFR) equation with three current main equations for measuring GFR in transplant recipients. Design Development and validation study Setting 17 cohorts Europe, United States, Australia (14 centres, clinical trials). Participants 15 489 adults (3622 development cohort (Necker, Saint Louis, Toulouse hospitals, France), 11 867 multiple external cohorts) who received...
In Brief Background The new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-based equation was developed to address the systematic underestimation of glomerular filtration rate (GFR) by Modification Diet in Renal (MDRD) Study patients with a relatively well-preserved kidney function. performance for transplant recipients is discussed. Methods We analyzed performances CKD-EPI comparison MDRD 825 stable recipients. Bias, precision, and accuracy within 30% true GFR were...
Introduction. The effects of long-term stretching (>6 months) in hemiparesis are unknown. This prospective, randomized, single-blind controlled trial compared changes architectural and clinical parameters plantar flexors individuals with chronic following a 1-year guided self-stretch program, conventional rehabilitation alone. Methods. Adults stroke-induced (time since lesion >1 year) were randomized into 1 2, programs: therapy (CONV) supplemented the Guided Self-rehabilitation...
Purpose To facilitate the demonstration of prognostic value radiomics, multicenter radiomics studies are needed. Pooling radiomic features such data in a statistical analysis is however challenging, as they sensitive to variability scanner models, acquisition protocols and reconstruction settings, which often unavoidable multicentre retrospective analysis. A harmonization strategy called ComBat was utilized deal with “center-effect”. The goal present work integrate transfer learning (TL)...
Background. Whether the new chronic kidney disease-epidemiology (CKD-EPI) equation without race variable remains accurate enough for glomerular filtration rate (GFR) estimation in non-US transplant recipients (KTRs) is unclear. We sought to compare predictive performance between this and classical CKD-EPI a French cohort of KTRs. also evaluated European Kidney Function Consortium (EKFC) equation, an estimate that has proved very nontransplant patients does not include variable. Methods....
The analysis of plaque mechanics along the longitudinal axis (bending strain) may provide useful information because repetitive bending strain an atherosclerotic can fatigue wall material and result in rupture. Whether essential hypertension is associated with a specific pattern has not yet been determined. study included 92 patients on common carotid artery: 66 hypertension, either treated or not, 26 normotensive patients. A novel noninvasive echotracking system (ArtLab; Esaote,...
Export Activation of complement through the alternative pathway has a key role in pathogenesis IgA nephropathy (IgAN). Large, international, genome-wide association studies have shown that deletion factor H–related genes 1 and 3 (CFHR3,1Δ) is associated with reduced risk developing IgAN, although prognostic value these deletions IgAN remains unknown. Here, we compared renal outcomes patients according to their CFHR3,1Δ genotype. This retrospective, monocentric cohort study included 639 white...
Abstract Purpose In this work, we addressed fully automatic determination of tumor functional uptake from positron emission tomography (PET) images without relying on other image modalities or additional prior constraints, in the context multicenter with heterogeneous characteristics. Methods cervical cancer, an challenge is location near even stuck to bladder. PET datasets 232 patients five institutions were exploited. To avoid unreliable manual delineations, ground truth was generated a...
To develop a radiomic model predicting nonresponse to induction chemotherapy in laryngeal cancers, from multicenter pretherapeutic contrast-enhanced computed tomography (CE-CT) and evaluate the benefit of feature harmonization such context.Patients (n = 104) eligible for preservation were included five centers. Primary tumor was manually delineated on CE-CT images. The following features extracted with an in-house software (MIRAS v1.1, LaTIM UMR 1101): intensity, shape, textural derived...
Within the field of biomaterials, control cell–surface interactions is generally addressed through surface chemistry modification. In this respect, Layer-by-Layer (LbL) coatings constitute promising versatile tools. Most cells are mechanosensitive, therefore stiffness their microenvironment should also be considered as a crucial parameter when designing polymer-based biomaterials. Here, we report on combination mechanics and LbL-treated polydimethylsiloxane substrates tunable to cell...
The prognosis of IgA nephropathy (IgAN) is very heterogeneous. Predicting the nature and rate disease progression crucial for refining patient treatment. aim this study was to evaluate prognostic impact an Oxford classification-based repeat kidney tissue evaluation predict end-stage renal (ESRD).Patients with biopsy-proven primary IgAN who underwent two biopsies at our centre were analyzed retrospectively. Renal scored by pathologists blinded clinical data according updated classification....
We retrospectively evaluated the ability of protein-A immunoadsorption (IA) as compared to that conventional plasma exchanges (PE) in reducing mean fluorescence intensity (MFI) anti-HLA antibodies assessed by single antigen assay sensitized renal transplant recipients. Change MFI 441 was measured after 1 session IA or 3 consecutive daily PE sessions. While both strategies were able significantly lower amount antibodies, relative reduction higher (-69 vs. -58%, respectively, p = 0.003). This...
Machine learning techniques are becoming increasingly popular in radiomics studies. They can handle high dimensional sets of features with higher robustness than usual statistical analyses, by capturing complex interactions between themselves and feature combinations clinical endpoints under investigation order to build efficient prognostic/predictive models. However, there is no "one fits all" solution deciding which algorithm the most accurate for a given application not always...
The International IgA Nephropathy Network developed a tool (IINN-PT) for predicting the risk of end-stage renal disease (ESRD) or 50% decline in estimated glomerular filtration rate (eGFR). We aimed to validate this French cohort with longer follow-up than previously published validation studies.The predicted survival patients biopsy-proven immunoglobulin A nephropathy (IgAN) from Saint Etienne University Hospital was computed IINN-PT models without ethnicity. primary outcome occurrence...