A5003345174- Cutaneous lymphoproliferative disorders research
- Autoimmune and Inflammatory Disorders
- Autoimmune Bullous Skin Diseases
- Eosinophilic Disorders and Syndromes
- Lymphoma Diagnosis and Treatment
- Skin Diseases and Diabetes
- Histiocytic Disorders and Treatments
- Vascular Tumors and Angiosarcomas
- Nail Diseases and Treatments
- Fungal Infections and Studies
- Dermatological and Skeletal Disorders
- Tumors and Oncological Cases
- Urticaria and Related Conditions
- Sarcoidosis and Beryllium Toxicity Research
- CNS Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Hidradenitis Suppurativa and Treatments
- T-cell and Retrovirus Studies
- Skin and Cellular Biology Research
- Genetic and rare skin diseases.
- Oral Health Pathology and Treatment
- Immune Cell Function and Interaction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Infectious Diseases and Tuberculosis
- Mycobacterium research and diagnosis
Hôpital Saint-Louis
2015-2024
Assistance Publique – Hôpitaux de Paris
2014-2024
Université Paris Cité
2013-2023
Inserm
2006-2022
Lymphoma Study Association
2022
Paris-Est Sup
2022
Institut de recherche Saint-Louis
2020
Délégation Paris 7
2011-2019
Charité - Universitätsmedizin Berlin
2019
European Organisation for Research and Treatment of Cancer
2018
Survival in mycosis fungoides (MF) is varied and may be poor. The PROCLIPI (PROspective Cutaneous Lymphoma International Prognostic Index) study a web-based data collection system for early-stage MF with legal data-sharing agreements permitting international collaboration rare cancer complex pathology. Clinicopathological must 100% complete in-built intelligence the database ensures accurate staging.
Blastic plasmacytoid dendritic cell neoplasm is a rare clinicopathologic entity, characterized by strong skin tropism and poor prognosis. The diagnosis generally made biopsy with appropriate immunohistochemical studies. To identify potential biological prognostic factors for blastic neoplasm, we performed an extended clinico-immunohistochemical study on series of 91 well-documented cases collected since 1995 the French Study Group Cutaneous Lymphomas. Skin biopsies were analyzed using panel...
<h3>Importance</h3> VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is a recently described severe adult-onset autoinflammatory disease that associated with myeloid lineage-restricted ubiquitin-activating enzyme 1 (<i>UBA1</i>) somatic variations primarily affect the skin (Sweet syndrome), cartilage, and bone marrow. Skin symptoms have been poorly described. <h3>Objective</h3> To better describe clinical pathological manifestations their pathophysiology in syndrome....
The treatment of advanced stage primary cutaneous T-cell lymphomas remains challenging. In particular, large-cell transformation mycosis fungoides is associated with a median overall survival two years for all stages taken together. Little known regarding allogeneic hematopoietic stem cell transplantation in this context. We performed multicenter retrospective analysis 37 cases treated transplantation, including 20 (54%) transformed fungoides. Twenty-four patients (65%) had IV disease (for...
Background Primary cutaneous lymphomas (PCLs) are a heterogeneous group of T-cell (CTCL) and B-cell (CBCL) malignancies. Little is known about their epidemiology at initial presentation in Europe potential changes over time. Objectives The aim this retrospective study was to analyse the frequency PCLs French Cutaneous Lymphoma Registry (GFELC) describe demography patients. Methods Patients with centrally validated diagnosis primary PCL, diagnosed between 2005 2019, were included. Results...
Abstract Background Dystrophic epidermolysis bullosa pruriginosa (DEB‐Pr) is a rare subtype of hereditary bullosa, with poorly understood pathogenesis and no satisfactory treatment. Objectives To assess the clinical biological features, genetic basis therapeutic management, to better characterize this genodermatosis. Methods We have conducted retrospective study, reviewing presentation, diagnosis, immunohistopathological findings characteristics management patients dystrophic pruriginosa....
VEXAS (Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is caused by acquired somatic mutations in UBA1. Sweet-syndrome-like skin disorders [and especially histiocytoid Sweet (HSS)] may be associated with syndrome.
Sweet syndrome is an acute neutrophilic dermatosis that occurs with malignant diseases, mainly myeloid hemopathies, in about 20% of cases. When associated myelodysplasia, may be clinically atypical. It can histologically unusual. Concomitant infiltration mature neutrophils and immature cells has been reported, its significance still debated. In few patients, lymphocytic infiltrates are the presenting feature myelodysplasia.We present 9 male adult patients chronic syndrome, all recurrent...
Abstract Background Microcystic adnexal carcinoma ( MAC ), syringomatous SC ) and “Squamoid eccrine ductal carcinoma” SEDC are rare sclerosing tumours. Objective To understand the histogenesis of these tumours possible clinical implications. Methods We conducted a retrospective study 30 cases, 18 , 5 7 reviewed classified by panel dermatopathology experts, with immunohistochemical analysis keratins, including K77, new keratin specific ducts, PHLDA 1 expressed in structures. Results There was...
† A 60-year-old woman had a typical pyoderma gangrenosum with monoclonal IgA gammopathy and atrophic gastritis. Two years after the onset of her skin disease, she evidence pulmonary abscesslike involvement. Corticosteroid therapy led to healing lung diseases. This case stresses multisystemic manifestations neutrophilic dermatoses special attention (<i>Arch Dermatol</i>. 1989;125:1239-1242)
<i>Background:</i> Alopecic and aseptic nodules of the scalp (AANS) is a new entity reported first in Japan as ‘pseudocyst scalp’. Only retrospective studies have been published. <i>Objectives:</i> To describe clinicopathological features AANS (pseudocyst), to evaluate response doxycycline compare results those obtained from patients with dissecting cellulitis (DCS). <i>Methods:</i> Fifteen 7 DCS were prospectively included. A puncture biopsy made....
Vemurafenib is a targeted therapy, used in patients with metastatic cutaneous melanoma who carry the BRAF V600E mutation, relative reduction of 63% risk death. Several adverse events have been described previously, such as photosensitivity or squamous-cell carcinomas. Two cases panniculitis reported recently two different selective inhibitors. We report neutrophilic treated by vemurafenib for melanoma. Clinical and biological examinations showed no indications an immune nor infectious cause...
Abstract Background Blau syndrome ( BS ) is a rare monogenic autoinflammatory disease caused by NOD 2 mutations. classically presents in early childhood as triad of granulomatous polyarthritis, uveitis and skin involvement. Joint ocular involvement have been characterized several cohort studies but only very little data are available on lesions. Objectives We aimed to provide detailed clinical microscopic analysis manifestations study whether they may contribute an diagnosis. Methods...
• Infantile acropustulosis is a syndrome characterized by recurrent crops of 1- to 2-mm pruritic vesiculopustules, which appear predominantly on distal extremities infants. Nine biopsy specimens from six cases infantile have been studied. We found that necrolysis keratinocytes the initial event leading an inflammatory reaction and intraepidermal pustule, progresses subcorneal pustule. These different histologic stages are correlated with clinical features. pustules may be filled neutrophils...