R. Stranzenbach
A5050004807- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- Fungal Infections and Studies
- CAR-T cell therapy research
- Nail Diseases and Treatments
- Autoimmune Bullous Skin Diseases
- CNS Lymphoma Diagnosis and Treatment
- Toxin Mechanisms and Immunotoxins
- T-cell and Retrovirus Studies
- Chronic Lymphocytic Leukemia Research
- Vascular Tumors and Angiosarcomas
- Immunotherapy and Immune Responses
- HIV Research and Treatment
- Streptococcal Infections and Treatments
- Urticaria and Related Conditions
- Chemotherapy-related skin toxicity
- Cancer and Skin Lesions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Skin Diseases and Diabetes
- Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Hidradenitis Suppurativa and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Psoriasis: Treatment and Pathogenesis
University Hospitals of the Ruhr-University of Bochum
2017-2025
Ruhr University Bochum
2017-2025
St. Josef-Hospital
2021-2025
Zahnklinik Bochum
2024
LWL-Universitätsklinikum Bochum
2021-2022
Johannes Wesling Klinikum Minden
2014-2021
Peter MacCallum Cancer Centre
2015-2018
European Organisation for Research and Treatment of Cancer
2018
The University of Melbourne
2018
The Christie Hospital
2015
Advanced-stage mycosis fungoides (MF; stage IIB to IV) and Sézary syndrome (SS) are aggressive lymphomas with a median survival of 1 5 years. Clinical management is based; however, there wide range outcome within stages. Published prognostic studies in MF/SS have been single-center trials. Because the rarity MF/SS, only large collaboration would power study identify independent markers.
Survival in mycosis fungoides (MF) is varied and may be poor. The PROCLIPI (PROspective Cutaneous Lymphoma International Prognostic Index) study a web-based data collection system for early-stage MF with legal data-sharing agreements permitting international collaboration rare cancer complex pathology. Clinicopathological must 100% complete in-built intelligence the database ensures accurate staging.
Cutaneous lymphomas (CL) are categorized as extranodal non-Hodgkin lymphomas, constituting the second most common form in this group (MALT of stomach form). Their incidence is estimated at one new diagnosis per 100,000 inhabitants year Germany [1-3]. Primary CL, by definition, present skin first, and time after staging completed do not show any involvement other organs. Secondary on hand, cutaneous manifestations disseminated [4], primarily nodal or leukemias. CL comprise a large, clinically...
The PROspective Cutaneous Lymphoma International Prognostic Index (PROCLIPI) study is a prospective analysis of an international database. Here we examine front-line treatments and quality life (QoL) in patients with newly diagnosed mycosis fungoides (MF).
We aimed to determine whether the pan-immune-inflammation value (PIV) of patients with Merkel cell carcinoma (MCC) at primary diagnosis differs from controls and it is associated disease stage outcome.In this retrospective study, we recruited MCC I-III. PIV was calculated absolute complete blood counts obtained within one week as follows: [neutrophils (103/mm3) × platelets monocytes (103/mm3)]/lymphocytes (103/mm3). As controls, studied age-gender-matched cutaneous melanoma (CM, I-III)...
Summary Background Total skin electron beam therapy (TSEBT) combined with systemic or maintenance treatment is a reasonable approach to enhance the remission rate and duration in mycosis fungoides (MF) Sézary syndrome (SS). This study assesses efficacy of oral bexarotene after low‐dose TSEBT for patients MF SS. Methods In this prospective observational study, we recruited MF/SS total without describe outcomes toxicities. Results Forty‐six subjects SS underwent between 2016 2021 at our...
Kutane Lymphome (cutaneous lymphomas; CL) gehören zur Gruppe der extranodalen Non-Hodgkin-Lymphome, innerhalb derer sie die zweithäufigste Form darstellen (Magen-MALT-Lymphome sind häufigste extranodale Form). Die Inzidenz wird auf eine Neuerkrankung pro Jahr und 100 000 Einwohner geschätzt [1-3]. Primäre CL manifestieren sich definitionsgemäß zunächst in Haut zeigen zum Zeitpunkt Diagnosestellung nach abgeschlossener Ausbreitungsdiagnostik (Staging) keine weitere Organbeteiligung, während...
Abstract Background Primary cutaneous B‐cell lymphomas (CBCL) are a group of rare malignant skin diseases that represent approximately 20%–30% all primary (PCL). Previous studies revealed impaired health‐related quality life (HRQoL) in patients diagnosed with T‐cell lymphoma (CTCL). Currently, only small‐sized investigated HRQoL CBCL and lacked detailed analysis respective subtypes. Objectives This study aims to investigate identify independent factors impairment patients. Methods One...
Sehr geehrte Herausgeber, Das bullöse Pemphigoid (BP) gehört zur Gruppe der bullösen Autoimmunerkrankungen. Es ist durch subepidermale Blasenbildung und Autoantikörper gegen hemidesmosomale Proteine gekennzeichnet.1-3 In Literatur wird das BP mit fortgeschrittenem Alter, neurologischen Erkrankungen, Medikamenten, paraneoplastischen Syndromen, genetischer Prädisposition ultraviolettem Licht in Verbindung gebracht.4, 5 einigen Berichten wurde eine Assoziation zwischen bakteriellen...
Treatment of advanced mycosis fungoides (MF) and Sézary syndrome (SS) is a challenge. In this international, multicenter, open-label phase II trial, we assessed the efficacy safety anti-PD-L1 atezolizumab in stage IIB-IV refractory/relapsed MF SS. Patients received 1200 mg IV Q3w for up to 1 year unless progression or withdrawal. The main study endpoints were overall response rate (ORR), progression-free survival (PFS), time next systemic treatment (TTNT), (OS). A total 26 patients enrolled...
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive type of haematologic precursor malignancy primarily often manifesting in the skin. We sought to provide thorough clinical characterization and report our experience on therapeutic approaches BPDCN.In present multicentric retrospective study, we collected all BPDCN cases occurring between 05/1999 03/2018 10 secondary care centres German-Swiss-Austrian cutaneous lymphoma working group.A total 37 were identified...
Background: Hidradenitis suppurativa (HS) is a debilitating, chronic inflammatory disease associated with multiple triggers. As the world struggles global COVID-19 pandemic, it important to review trigger factors for chronically ill HS patients during pandemic. This work investigates self-described of that emerged outbreak. Methods: We anonymously surveyed 110 SARS-CoV-2 pandemic using 25-question questionnaire included deterioration. Demographic, personal, and HS-specific information was...