A5060699000- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Nail Diseases and Treatments
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Fungal Infections and Studies
- Pancreatic and Hepatic Oncology Research
- Chemotherapy-related skin toxicity
- Cancer therapeutics and mechanisms
- CNS Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- CAR-T cell therapy research
- Dermatological diseases and infestations
- Contact Dermatitis and Allergies
- Neutropenia and Cancer Infections
- Acne and Rosacea Treatments and Effects
- Viral-associated cancers and disorders
- Drug-Induced Adverse Reactions
- Cutaneous Melanoma Detection and Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metastasis and carcinoma case studies
- Monoclonal and Polyclonal Antibodies Research
Medical University of Vienna
2009-2024
Universitätszahnklinik Wien
2020-2024
Vienna General Hospital
1998-2006
Advanced Dermatology
2006
University of Vienna
1998-2003
Fachhochschule Wiener Neustadt
1999
Lymphoma of the mucosa-associated lymphoid tissue (MALT) type usually arises in MALT acquired through chronic antigenic stimulation triggered by persistent infection and/or autoimmune processes. Due to specific ligand-receptor interactions between cells and high-endothelial venules MALT, both normal neoplastic display a pronounced homing tendency throughout body. In case disease these properties may be responsible for lymphoma dissemination among various MALT-sites. According this concept,...
<i>Introduction:</i> Carcinoma of the biliary system is a rare tumor entity, and patients with advanced disease face dismal prognosis. Because absence standard chemotherapy for carcinoma, we have performed two consecutive studies to evaluate clinical potential 5-fluorouracil, leucovorin mitomycin C as well novel antimetabolite gemcitabine in this disease. <i>Patients Methods:</i> A total 39 suffering from locally inoperable or metastatic cancer were enrolled study...
In contrast to nodal follicular lymphoma, limited data exist on genetic changes in primary cutaneous lymphoma (primary follicle center according WHO-EORTC). The detection rate of the BCL2 rearrangement, representing characteristic t(14;18)(q32;q21) underlying by polymerase chain reaction (PCR) has been reported vary over a wide range (0%-41%), and only few cases have studied molecular cytogenetic techniques such as fluorescence situ hybridization (FISH). this study, 27 lymphomas were...
PURPOSE: To evaluate the efficacy and tolerance of combined irinotecan oxaliplatin in patients with advanced colorectal cancer pretreated leucovorin-modulated fluoropyrimidines. PATIENTS AND METHODS: Thirty-six metastatic cancer, who progressed while receiving or within 6 months after discontinuing palliative chemotherapy fluoropyrimidines/leucovorin, were enrolled onto this study. Treatment consisted 85 mg/m 2 on days 1 + 15 80 8 every 4 weeks. Depending absolute neutrophil counts (ANC) day...
The Revised Illness Perception Questionnaire (IPQ-R) has been shown to assess illness perception reproducibly in primary cutaneous T-cell lymphomas (CTCL). reflects patients' individual concepts of understanding and interpretation the disease, influencing behaviour health-related quality life (HRQOL). This study investigated clinical relevance relationships between perception, behaviour, HRQOL CTCL B-cell (CBCL). A total 92 patients completed IPQ-R, Scale for Assessment Behavior (SAIB), a...
BACKGROUND Surgical intervention and combined modality treatment including radiation chemotherapy have been studied widely in patients with high grade gastric B-cell lymphoma, whereas to the authors' knowledge role of alone localized disease has not investigated extensively. METHODS Twenty-five consecutive primary lymphoma modifed Ann Arbor Stages IE IIE were prospectively at study institution. Patients age < 75 years (n = 17; range, 41–75 years) given a standard regimen comprised...
Abstract We previously described the expression of melanoma-associated endogenous retrovirus (MERV) proteins and viral particles in human melanomas metastases. The objective present study was to determine whether a humoral immune response MERV occurs melanoma. Candidate B-cell epitopes on were predicted using bioinformatic screening. reactivity peptides corresponding with antibodies prevalent sera melanoma patients analyzed. An immunodominant peptide located env protein identified....
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive type of haematologic precursor malignancy primarily often manifesting in the skin. We sought to provide thorough clinical characterization and report our experience on therapeutic approaches BPDCN.In present multicentric retrospective study, we collected all BPDCN cases occurring between 05/1999 03/2018 10 secondary care centres German-Swiss-Austrian cutaneous lymphoma working group.A total 37 were identified...
Overexpression of hypoxia inducible factor (HIF)-1alpha has been found in several human cancers and is thought to correlate with aggressive disease poor response. A retrospective analysis was carried out on 89 patients primary cutaneous melanoma. HIF-1alpha expression assessed by immunohistochemistry formalin-fixed, paraffin wax-embedded tumour sections. Overall survival (OS) disease-free (DFS) were determined using univariate multivariate analyses. Of the patients, 78 (87.6%) expressed...
Although the novel cytidin analogue gemcitabine has shown superior anti-tumour activity than 5-fluorouracil in advanced pancreatic cancer, further improvements of therapeutic results are warranted. This goal might be achieved by combining with other active drugs. trial evaluated efficacy and tolerance such a combination regimen epirubicin granulocyte colony-stimulating factor (G-CSF) patients metastatic disease. Seventy adenocarcinoma were enrolled this multicentre trial. Patients received...
Abstract Background The Langerhans cell (LC) hypothesis suggests that cutaneous T‐cell lymphomas (CTCL) are diseases of chronic stimulation by LC‐mediated antigen presentation. Objective To investigate a broad panel CTCL and B‐cell (CBCL) for the spatial association langerin + dendritic cells (DC) with T B in skin, respectively. Methods Fifty‐five specimens 10 CBCL were double‐stained monoclonal antibodies against CD3 or CD20, respectively, evaluated confocal laser scan microscopy. Results...
ObjectiveTo optimize the permethrin-based therapies for scabies infestations in infants and young children, efficacies of 3 different regimens were evaluated.Study designThe retrospective analysis encompassed 85 children aged <4 years with scabies. The had received either topical permethrin 5% on entire body days 1/8, 1/8/15, 1/8/15 plus interim applications restricted to hands feet 2/3/4//9/10/11, or alternative treatments.ResultsThe intensified regimen, consisting full-body applied...
Introduction: Irinotecan and oxaliplatin are two new agents with promising activity in advanced colorectal cancer. Based on preclinical clinical evidence that both drugs might act synergistically mitomycin C, a randomized study using ‘pick the winner’ design was undertaken to determine effectiveness tolerance of these combination schedules patients fluoropyrimidine/leucovorin-pretreated Patients Methods: Sixty-four metastatic cancer, who progressed while receiving or within 6 months after...
<b><i> Background:</i></b> There is no standard therapy for the treatment of patients with nonresectable biliary tract carcinomas who face a particularly dismal prognosis. In view urgent need to define better treatments and conflicting data on therapeutic potential gemcitabine in this disease, we have performed 2 consecutive clinical investigations using different dose schedules novel antimetabolite. <b><i>Patients Methods: </i></b>38 locally or metastatic cancer were enrolled study; 24...
A 43‐year‐old woman was admitted to hospital with a history of recurrent attacks vertigo, which had been treated carbamazepine for 4 weeks. The patient presented fever, cold chills, lymphadenopathy, and erythematous highly infiltrated skin. Nikolski phenomenon negative there no pruritus. Symptoms begun 5 days earlier, diffuse maculopapular exanthema, first localized on the breast trunk, consecutive generalization, accompanied by severe enteritis. exanthema worsened state generalized...
Summary Background and Objectives Mycosis fungoides (MF), the most common primary cutaneous T‐cell lymphoma, is characterized by a variable clinical course, presenting either as indolent disease or showing fatal progression due to extracutaneous involvement. Importantly, lack of prognostic models predominantly palliative therapy settings hamper patient care. Here, we aimed define survival rates, prediction accuracy, treatment impact in MF. Patients methods Hundred‐forty MF patients were...