A5067689004- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Dermatology and Skin Diseases
- T-cell and Retrovirus Studies
- Immunotherapy and Immune Responses
- Fungal Infections and Studies
- Psoriasis: Treatment and Pathogenesis
- Autoimmune Bullous Skin Diseases
- Nail Diseases and Treatments
- T-cell and B-cell Immunology
- Eosinophilic Disorders and Syndromes
- Urticaria and Related Conditions
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Mast cells and histamine
- Lymphatic System and Diseases
- Asthma and respiratory diseases
- Viral-associated cancers and disorders
- IL-33, ST2, and ILC Pathways
- Inflammatory Myopathies and Dermatomyositis
- CNS Lymphoma Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cell Adhesion Molecules Research
- Dermatologic Treatments and Research
International University of Health and Welfare
2017-2025
Nihon University
2022
The University of Tokyo
2012-2021
Kyushu University
2021
Peter MacCallum Cancer Centre
2015-2018
Tokyo Medical University
2018
The University of Melbourne
2018
University of Tokyo Hospital
2017
National Center for Global Health and Medicine
2011-2016
The Christie Hospital
2015
Mycosis fungoides (MF) and Sézary syndrome (SS), the major forms of cutaneous T-cell lymphoma, have unique characteristics that distinguish them from other types non-Hodgkin's lymphomas. Clinical trials in MF/SS suffered a lack standardization evaluation, staging, assessment, end points, response criteria. Recently defined criteria for diagnosis early MF, guidelines initial revised staging classification MF SS now offer potential uniform patients enrolled clinical MF/SS. This article...
Advanced-stage mycosis fungoides (MF; stage IIB to IV) and Sézary syndrome (SS) are aggressive lymphomas with a median survival of 1 5 years. Clinical management is based; however, there wide range outcome within stages. Published prognostic studies in MF/SS have been single-center trials. Because the rarity MF/SS, only large collaboration would power study identify independent markers.
Langerhans cells (LCs) constitute a subset of DCs that initiate immune responses in skin. Using leprosy as model, we investigated whether expression CD1a and langerin, an LC-specific C-type lectin, imparts specific functional role to LCs. LC-like freshly isolated epidermal LCs presented nonpeptide antigens Mycobacterium leprae T cell clones derived from patient CD1a-restricted langerin-dependent manner. were more efficient at antigen presentation than monocyte-derived DCs. lesions coexpress...
Langerhans cells (LCs) constitute a subset of DCs that initiate immune responses in skin. Using leprosy as model, we investigated whether expression CD1a and langerin, an LC-specific C-type lectin, imparts specific functional role to LCs. LC-like freshly isolated epidermal LCs presented nonpeptide antigens Mycobacterium leprae T cell clones derived from patient CD1a-restricted langerin-dependent manner. were more efficient at antigen presentation than monocyte-derived DCs. lesions coexpress...
Langerhans cells (LCs) are suspected to be initial targets for HIV after sexual exposure (by becoming infected or by capturing virus). Here, productive R5 infection of LC ex vivo and LC-mediated transmission virus CD4 + T were both found depend on CCR5. By contrast, monocyte-derived dendritic transfer from mediated CCR5-dependent as well DC-specific ICAM-3-grabbing nonintegrin-dependent pathways. Furthermore, in 62 healthy individuals, levels LCs associated with CCR5 genotype. Specifically,...
Accumulating epidemiologic evidence has revealed that metabolic syndrome is an independent risk factor for psoriasis development and associated with more severe psoriasis. Adiponectin, primarily recognized as a mediator of insulin sensitivity, been newly drawing attention immune responses. Here we demonstrate adiponectin regulates skin inflammation, especially IL-17-related psoriasiform dermatitis. Mice deficiency show inflammation enhanced infiltration IL-17-producing dermal Vγ4+γδ-T cells....
We examined the effects of walk training combined with leg blood flow reduction (BFR) on muscle hypertrophy as well peak oxygen uptake (VO2peak) in older individuals. Both BFR (BFR-Walk, n = 10, age; 64 ± 1 years, body mass index [BMI]; 22.5 0.9 kg/m2) and control (CON-Walk, 8, 68 BMI; 23.2 1.0 groups performed 20 minutes treadmill walking at an exercise intensity 45% heart rate reserve, 4 days per week, for 10 weeks. The BFR-Walk group wore pressure belts (160–200 mm Hg) both legs during...
Abstract Background and Objectives An increased serum C‐reactive protein (CRP) level was found in patients with various malignant tumors associated poor prognosis. The aim of this study to analyze the clinicopathological significance prognostic value preoperative CRP levels esophageal squamous cell carcinomas. Patients Methods measured by enzyme‐linked immunosorbent assay (ELISA) 150 primary All underwent radical surgery without any therapy. were divided into two groups using a cut‐off 1.0...
Both patients with cutaneous T-cell lymphoma (CTCL) and those atopic dermatitis (AD) have pruritus, T(H)2-biased T cells, a tendency to bacterial infections, suggesting common pathologic basis for these two diseases. Recently, interleukin (IL)-22-producing cells were reported in skin of AD. In this study, we investigated expression levels T(H)22- T(H)17-related molecules lesional sera isolated from CTCL.Skin biopsies collected CTCL or psoriasis healthy volunteers. Protein mRNA IL-22, IL-17A,...
ABSTRACT Psoriasis is an inflammatory cutaneous disorder characterized by marked epidermal thickening and Th1 Th17 cell infiltration. At present, the contribution of B cells to pathogenesis psoriasis unclear. In mice, topical application imiquimod induces inflamed skin lesions serves as experimental animal model for human psoriasis. this study, we showed that imiquimod-induced inflammation was more severe in CD19−/− than WT mice. These responses were negatively regulated a unique...
Abstract Gout occurs in individuals with hyperuricemia when monosodium urate (MSU) crystals precipitate tissues and induce acute inflammation via phagocytic cells such as monocytes. MSU have been demonstrated skin diseases tophaceous gout or psoriasis; however, the importance of is totally unknown. In this study, we found that crystals, through P2Y6 receptors, stimulated normal human keratinocytes (NHK) to produce IL-1α, IL-8/CXCL8, IL-6. receptor expression increased MSU-stimulated NHK....
Thymic stromal lymphopoietin (TSLP) activates dendritic cells to induce Th2-mediated inflammation. Periostin, an extracellular matrix protein produced by fibroblasts, induces chronic inflammation stimulating TSLP production. Recently, a reinforcing cycle linking Th2-type immune responses with periostin-induced keratinocyte activation has been proposed in atopic dermatitis pathogenesis. In this study, we investigated the role of and periostin development cutaneous T-cell lymphoma (CTCL),...
Journal Article Serum IL‐33 levels are increased in patients with psoriasis Get access A. Mitsui, Mitsui Department of Dermatology University Tokyo Graduate School Medicine Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Tada, Tada Correspondence: Dr Yayoi Dermatology, Faculty Medicine, Tokyo, 7‐3–1 Hongo, Bunkyo‐ku, 113‐8655, E‐mail: ytada-tky@umin.ac.jp T. Takahashi, Takahashi S. Shibata, Shibata M. Kamata, Kamata Miyagaki, Miyagaki H. Fujita, Fujita...
Abstract Background CC chemokine ligand (CCL) 18 is expressed by monocytes and dendritic cells (DCs), has potent chemotactic activity for T cells, B DCs. CCL18 expression up‐regulated in lesional skin of atopic dermatitis bullous pemphigoid, suggesting its important roles the development these diseases. Objective To investigate cutaneous T‐cell lymphoma (CTCL). Methods The messenger RNA (mRNA) CTCL ( n = 21) normal 7) was examined quantitative RT‐PCR. also immunohistochemistry. Serum levels...