A5102900456- Microbial Community Ecology and Physiology
- Marine and coastal ecosystems
- Mercury impact and mitigation studies
- Marine Biology and Ecology Research
- Isotope Analysis in Ecology
- Protist diversity and phylogeny
- Methane Hydrates and Related Phenomena
- Systemic Sclerosis and Related Diseases
- Genomics and Phylogenetic Studies
- Cutaneous lymphoproliferative disorders research
- Environmental DNA in Biodiversity Studies
- Lymphoma Diagnosis and Treatment
- Marine animal studies overview
- Cardiac Valve Diseases and Treatments
- Coastal wetland ecosystem dynamics
- Cardiac tumors and thrombi
- T-cell and Retrovirus Studies
- Ocean Acidification Effects and Responses
- Wastewater Treatment and Nitrogen Removal
- Atmospheric chemistry and aerosols
- Gut microbiota and health
- Nuclear Receptors and Signaling
- Coral and Marine Ecosystems Studies
- IL-33, ST2, and ILC Pathways
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
National Institute for Minamata Disease
2018-2023
Akita University
2023
The University of Tokyo
2008-2020
Hokkaido University
2013-2017
Japan Agency for Marine-Earth Science and Technology
2017
Iwate University
2016
Leibniz Institute of Freshwater Ecology and Inland Fisheries
2013
Sphere Institute
2011
Hiroshima University
2007
Nippon Medical School
1991
Growth and productivity of phytoplankton substantially change organic matter characteristics, which affect bacterial abundance, productivity, community structure in aquatic ecosystems. We analyzed structures measured activities inside outside blooms the western North Pacific Ocean by using bromodeoxyuridine immunocytochemistry fluorescence situ hybridization (BIC-FISH). Roseobacter/Rhodobacter, SAR11, Betaproteobacteria, Alteromonas, SAR86, Bacteroidetes responded differently to changes...
Summary Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease characterized by the predominant infiltration of T cells, eosinophils macrophages in lesional skin. Recently, macrophage-derived chemokine (MDC)/CCL22, CC chemokine, was identified as selective chemoattractant for receptor 4 (CCR4)-expressing addition to thymus activation-regulated (TARC). We have previously reported that serum TARC levels correlate with severity AD. In this report, we investigated...
Abstract Background CC chemokine ligand (CCL) 18 is expressed by monocytes and dendritic cells (DCs), has potent chemotactic activity for T cells, B DCs. CCL18 expression up‐regulated in lesional skin of atopic dermatitis bullous pemphigoid, suggesting its important roles the development these diseases. Objective To investigate cutaneous T‐cell lymphoma (CTCL). Methods The messenger RNA (mRNA) CTCL ( n = 21) normal 7) was examined quantitative RT‐PCR. also immunohistochemistry. Serum levels...
Mercury (Hg) methylation genes (hgcAB) mediate the formation of toxic methylmercury and have been identified from diverse environments, including freshwater marine ecosystems, Arctic permafrost, forest paddy soils, coal-ash amended sediments, chlor-alkali plants discharges geothermal springs. Here we present first attempt at a standardized protocol for detection, identification quantification hgc metagenomes. Our Hg-cycling microorganisms in aquatic terrestrial ecosystems (Hg-MATE) database,...
Abstract Backgrounds Adiponectin has been demonstrated to be one of anti‐inflammatory and anti‐fibrotic factors, suggesting the potential this cytokine involved in developmental process systemic sclerosis (SSc). Objective The aim study was investigate clinical significance serum adiponectin levels patients with SSc. Methods Serum were determined using enzyme‐linked immunosorbent assay (ELISA) 32 diffuse cutaneous SSc (dcSSc), 28 limited (lcSSc) 27 healthy controls. No significant difference...
Silver (Ag) nanoparticles were produced using DNA extracted from salmon milt as templates. Particles spherical in shape with an average diameter smaller than 10 nm obtained. The consisted of Ag the core outermost thin layer DNA. DNA/Ag hybrid immobilized over surface cotton based fabrics and their antibacterial efficiency was evaluated E. coli typical Gram-negative bacteria. experiments performed according to Antibacterial Standard Japanese Association for Functional Evaluation Textiles....
ABSTRACT A fundamental question in microbial oceanography concerns the relationship between prokaryote diversity and biogeochemical function an ecosystem context. We combined bromodeoxyuridine (BrdU) magnetic bead immunocapture PCR-denaturing gradient gel electrophoresis (BUMP-DGGE) to examine phylotype-specific growth natural marine assemblages. also examined a broad range of bacterial isolates determine their abilities incorporate BrdU order test validity method for application diverse...
ABSTRACT Incubation experiments using filtered waters from Lake Kasumigaura were conducted to examine bacterial contribution a dissolved organic carbon (DOC) pool. Bacterial abundance, production, concentrations of DOC, total amino acids (TDAA), and neutral sugars (TDNS) monitored during the experiments. production first few days was very high (20 35 μg C liter −1 day ), accounting for 40 70% primary production. The accounted 34 55% DOC loss experiment, indicating activities in Kasumigaura....
Background Lipocalin-2 is an adipocytokine implicated in apoptosis, innate immunity, angiogenesis, and the development of chronic kidney disease. Objectives To investigate role lipocalin-2 systemic sclerosis (SSc). Materials methods Serum levels were determined by enzyme-linked immunosorbent assay 50 patients with SSc 19 healthy subjects. expression was evaluated skin bleomycin (BLM)-treated mice Fli1-deficient endothelial cells reverse transcriptase-real time polymerase chain reaction,...
The recalcitrant fraction of marine dissolved organic matter (DOM) plays an important role in carbon storage on the earth's surface. Bacterial production DOM (RDOM) has been proposed as a sequestration process. It is still unclear whether bacterial physiology can affect RDOM production. In this study, we conducted batch culture using isolate Alteromonas macleodii, ubiquitous gammaproteobacterium, to evaluate linkage between growth and Glucose (1 mmol C L-1) was used sole source, number,...
In natural environments, the production of neurotoxic and bioaccumulative methylmercury (MeHg) is mediated by microorganisms carrying genes hgcA hgcB. However, contribution these to mercury (Hg) methylation or MeHg accumulation in ocean poorly understood. Here we determined total Hg (THg) concentrations seawater samples conducted a metagenomic survey hgcAB functional modules involved metabolic pathways East China Sea (ECS). analyses, used paired-end reads assembled contigs for enumeration...
A large part of marine dissolved organic matter (DOM) is considered to be recalcitrant DOM (RDOM) produced by bacteria. However, it still unclear whether differences in bacterial species and/or physiology control the efficiency RDOM production. Here, batch culture experiments with glucose as sole carbon source were carried out using three model strains, namely, Alteromonas macleodii (Alt), Vibrio splendidus (Vib) and Phaeobacter gallaeciensis (Pha). Dissolved (DOC) concentrations drastically...
Many patients with cutaneous T-cell lymphoma (CTCL) experience severe pruritus. This study evaluated serum levels of nerve growth factor (NGF) and brain-derived neurotrophic (BDNF) in CTCL. Although NGF BDNF CTCL were not significantly higher than healthy controls, Sézary syndrome those mycosis fungoides controls. Enhanced expression by keratinocytes increased dermal fibres detected lesional skin subjects syndrome. Correlations between pruritus NGF, BDNF, chemokine (C-C motif) ligand 1...
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 490:11-22 (2013) - DOI: https://doi.org/10.3354/meps10481 Enrichment of microbial abundance in sea-surface microlayer over a coral reef: implications for biogeochemical cycles reef ecosystems Ryota Nakajima1,*, Kenji Tsuchiya2, Nobuyuki Nakatomi2, Teruaki Yoshida3, Yuya Tada4, Fumie Konno2, Tatsuki Toda2,...
Abstract Background Apelin is a bioactive peptide exerting its pro‐angiogenic and pro‐fibrotic effects in context‐dependent manner through the activation of receptor APJ, which ubiquitously expressed on surface various cell types. The apelin/APJ signalling appears to be involved pathological process fibrotic disorders, including liver cirrhosis. Objective As an initial step clarify role pathogenesis systemic sclerosis (SSc), we investigated serum apelin levels their clinical association...
Abstract Background Retinol binding protein‐4 (RBP‐4) is a member of adipocytokines, which potentially associated with fibrosis, vasodilation, and angiogenesis in addition to insulin resistance. Objective To investigate the clinical significance serum RBP4 levels patients systemic sclerosis (SSc), autoimmune disease characterized by fibrosis vasculopathy. Methods Serum were determined enzyme‐linked immunosorbent assay 62 SSc 19 healthy controls. Results Similar chronic kidney disease,...
Abstract Background A disintegrin and metalloprotease (ADAM) 12 is one of the metalloproteinase‐type ADAMs possesses extracellular cell‐binding functions. ADAM12 expressed in two alternative forms, such as a membrane‐anchored form (ADAM12‐L) short secreted (ADAM12‐S). Objective To investigate clinical significance serum ADAM12‐S levels systemic sclerosis (SSc). Methods Serum were determined by specific enzyme‐linked immunosorbent assay 61 SSc patients 18 healthy controls. Results...
Angiogenesis is a crucial process in the growth and progression of cancer, correlating with metastatic potential tumour cells. Angiopoietins are ligands for endothelium-specific tyrosine kinase Tie2 receptor, which comprise 4 structurally related proteins, termed angiopoietin (Ang)-1, Ang-2, Ang-3 Ang-4. The roles Ang-1 Ang-2 have recently been clarified as angiogenesis. In this report, we measured serum levels patients cutaneous T-cell lymphoma (CTCL). Serum but not Ang-1, Sézary syndrome...
Dissolved organic matter derived from phytoplankton (DOMP) can affect the bacterial biomass and community structure in aquatic ecosystems. Here, we examined response of free-living heterotrophic bacteria, with respect to cellular nucleic acid levels, DOMP lysates three strains open tropical Pacific. The free amino (FAA) composition each lysate differed among microalgal strains. Terminal restriction fragment-length polymorphism analyses 16S rRNA genes revealed that shifts high (HNA) low (LNA)...