A5102837188- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Dermatology and Skin Diseases
- T-cell and Retrovirus Studies
- Fungal Infections and Studies
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Psoriasis: Treatment and Pathogenesis
- Cancer Immunotherapy and Biomarkers
- Transplantation: Methods and Outcomes
- Nail Diseases and Treatments
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Organ Transplantation Techniques and Outcomes
- Cytomegalovirus and herpesvirus research
- Ubiquitin and proteasome pathways
- Eosinophilic Disorders and Syndromes
- Xenotransplantation and immune response
- Polyomavirus and related diseases
- Medical Imaging and Pathology Studies
- Toxin Mechanisms and Immunotoxins
- Tracheal and airway disorders
- Inflammatory Myopathies and Dermatomyositis
- Renal Transplantation Outcomes and Treatments
Massachusetts General Hospital
2022-2025
Harvard University
2022-2025
Center for Cancer Research
2022-2025
The University of Tokyo
2004-2022
Tokushima University
2021
Utsunomiya University
1999-2017
University of Tokyo Hospital
2017
National Center for Global Health and Medicine
2015-2016
Kanto Central Hospital
2002-2015
Fujita Health University Hospital
2013
Abstract While BRAF inhibitor combinations with EGFR and/or MEK inhibitors have improved clinical efficacy in V600E colorectal cancer (CRC), response rates remain low and lack durability. Preclinical data suggest that BRAF/MAPK pathway inhibition may augment the tumor immune response. We performed a proof-of-concept single-arm phase 2 trial of combined PD-1, sparatlizumab (PDR001), dabrafenib trametinib 37 patients CRC. The primary end point was overall rate, secondary points were...
The continuous rise in skin cancer incidence highlights an imperative for improved prevention. Topical calcipotriol-plus-5-fluorouracil (calcipotriol-plus-5-FU) immunotherapy effectively eliminates precancerous lesions and prevents squamous cell carcinoma (SCC) patients. However, its mechanism of action remains unclear. Herein, we demonstrate that calcipotriol-plus-5-FU induces T helper type 2 (Th2) immunity, eliminating premalignant keratinocytes humans. CD4+ Th2 cells were required...
Thymic stromal lymphopoietin (TSLP) activates dendritic cells to induce Th2-mediated inflammation. Periostin, an extracellular matrix protein produced by fibroblasts, induces chronic inflammation stimulating TSLP production. Recently, a reinforcing cycle linking Th2-type immune responses with periostin-induced keratinocyte activation has been proposed in atopic dermatitis pathogenesis. In this study, we investigated the role of and periostin development cutaneous T-cell lymphoma (CTCL),...
CXCL17 is expressed in a variety of cancers and promotes tumor progression by recruiting myeloid-derived suppressor cells (MDSCs). MDSCs suppress immunity attracting regulatory T (Tregs) into sites through CCL5. In this study, we examined the role skin disorders. mRNA levels psoriasis skin, but not lesional atopic dermatitis or cutaneous cell lymphoma, were significantly higher than those normal skin. was mainly epidermis, IFN-γ dose-dependently increased expression human keratinocytes...
Although sulindac is known to cause regression of colorectal adenomatous polyps in familial polyposis, less about the effect on sporadic adenomas. The precise mechanisms these effects also remain be determined.Sulindac was given patients with evaluate its them, and histological analysis performed elucidate mechanism polyp regression, as well kind polys that are susceptible agent.20 15 were studied.Sulindac (300 mg daily) for four months, followed by colonoscopy removal residual polyps. Polyp...
// Takayuki Kimura 1, 2 , Makoto Sugaya Tomonori Oka Andrew Blauvelt 3 Hitoshi Okochi Shinichi Sato 1 Department of Dermatology, Faculty Medicine, University Tokyo, Japan Regenerative Research Institute, National Center for Global Health and Oregon Medical Center, Portland, Oregan, USA Correspondence to: Sugaya, e-mail: sugayam-der@h.u-tokyo.ac.jp Keywords: lymphatics, lymphedema, tumor immunity, cytotoxic T cells Received: March 18, 2015 Accepted: May 11,...
Whereas atopic dermatitis (AD) is considered as a T helper 2 (Th2)-centered disease, IL-17–producing Th (Th17) cells are also activated in AD lesional skin. However, the relationship between Th17 responses and Th2 still to be elucidated. Although increased skin, expression function of IL-26, which produced by cells, unknown. In this report, we demonstrated that IL-26 mRNA levels were elevated skin compared with healthy controls IL-26-producing immunohistochemistry. Furthermore, promoted...
Anti-glutamic acid decarboxylase antibody is associated with the development of progressive cerebellar ataxia and slowly insulin-dependent diabetes mellitus. Previously, neurophysiological characteristics IgG in cerebrospinal fluid a patient anti-glutamic antibody-associated mellitus were reported. Using voltage-gated whole-cell recording technique, it was observed that selectively suppressed inhibitory postsynaptic currents Purkinje cells. The died from aspiration pneumonia. Postmortem...
Despite harboring the highest tumor mutational burden of all cancers, basal cell carcinoma (BCC) has low immunogenicity. Here, we demonstrate that BCC's immunogenicity is associated with epigenomic suppression antigen presentation machinery reminiscent its origin. Primary BCC had T infiltrates and human leukocyte class I (HLA-I) expression compared cutaneous squamous (SCC) normal keratinocytes. Forkhead box C1 (Foxc1), a regulator quiescence in hair follicle stem cells, was expressed BCC....
Senescence-accelerated mouse (SAM) has been characterized as a unique animal model to investigate spontaneous aging well age-related disorders. However, little is known about the properties of lung. We examined morphologic and functional changes lung in SAM P2, senescence-prone strain, R1, senescence-resistant strain. On examination, earlier (starting at 6 mo) more severe change airspace size (mean linear intercept: MLI) was observed P2 (MLI [micron]; 3 mo: 72.1 +/- 2.4; 80.8 2.9; 12 91.1...
Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide expressed in the central nervous system and peripheral organs. Previous studies revealed role distribution of PACAP rodent testis, however, its presence human testis testicular germ cell tumors not known. We used RT-PCR immunohistological observations to investigate whether tissue contain PACAP. The mRNAs for receptors were detected total RNA extracted from testes. immunoreactivity was observed spermatogonia spermatids...
Abstract RAS mutations are common oncogenic drivers, occurring in 20% of human cancers, with KRAS present 40% colorectal cancer (CRC) cases. These constitutively activate the MAPK pathway, driving tumor progression. Although KRAS-G12C inhibitors have shown success non-small cell lung cancer, their efficacy CRC remains limited, response rates below 20%. Emerging evidence suggests signaling fosters an immunosuppressive microenvironment. Using a syngeneic mouse model, we investigated how...
Interleukin-19 (IL-19), a pro-inflammatory cytokine known to stimulate the production of T helper type 2 (Th2) cytokines, is induced by IL-17A and highly expressed in lesional skin psoriasis atopic dermatitis (AD). This aim this study was investigate whether IL-19 involved cutaneous T-cell lym-phoma (CTCL) AD. levels were significantly higher sera patients with AD those advanced-stage CTCL than normal controls, correlating clinical disease markers. mRNA both diseases elevated....
Galectin-9 is a member of the galectin family that has wide spectrum biological functions. Among them, galectin-9 been known mainly as potent chemoattractant for eosinophils. In addition, alters T-cell balance by negatively regulating T-helper (Th)1 and Th17 cells, resulting in Th2 polarization. Atopic dermatitis (AD) skin allergic disease characterized peripheral eosinophilia, mast cell activation predominance cells. To investigate possible roles AD, we measured serum levels AD patients...
Angiogenesis is regarded as an essential step in supporting tumour growth and metastasis. In haematological malignancies, including cutaneous T-cell lymphoma (CTCL), angiogenesis increased serum levels of some pro-angiogenic markers are elevated. The aim this study was to investigate expression placental factor (PlGF) vascular endothelial (VEGF)-A lesional skin sera patients with CTCL, assess the association these factors development CTCL. A further effect PlGF on cell vivo using a...