A5056281938- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- CAR-T cell therapy research
- Cancer, Stress, Anesthesia, and Immune Response
Center for Cancer Research
2022-2025
Massachusetts General Hospital
2022-2025
Harvard University
2022-2024
Cancer immunology research is largely focused on the role of cytotoxic immune responses against advanced cancers. Herein, we demonstrate that CD4+ T helper (Th2) cells directly block spontaneous breast carcinogenesis by inducing terminal differentiation cancer cells. Th2 cell immunity, stimulated thymic stromal lymphopoietin, caused epigenetic reprogramming tumor cells, activating mammary gland and suppressing epithelial–mesenchymal transition. polarization was required for this...
The continuous rise in skin cancer incidence highlights an imperative for improved prevention. Topical calcipotriol-plus-5-fluorouracil (calcipotriol-plus-5-FU) immunotherapy effectively eliminates precancerous lesions and prevents squamous cell carcinoma (SCC) patients. However, its mechanism of action remains unclear. Herein, we demonstrate that calcipotriol-plus-5-FU induces T helper type 2 (Th2) immunity, eliminating premalignant keratinocytes humans. CD4+ Th2 cells were required...
Lung cancer is the leading cause of deaths in United States and across world. Immunotherapies, which activate tumor-infiltrating cytotoxic T lymphocytes, have demonstrated efficacy for treatment advanced-stage lung cancer. However, potential harnessing immune system against early stages carcinogenesis to prevent development recurrence remains unexplored. Using a mouse model adenocarcinoma, we investigated effects thymic stromal lymphopoietin (TSLP) induction on lungs. Herein, demonstrate...
Adult human skin contains nearly twice as many T cells the peripheral blood, which include tissue-resident memory (TRM) cells. However, precise mechanisms maintaining TRM in healthy remain unclear. Using normal samples, we find that Langerhans (LCs) contact epidermis of elderly. LCs with high leukocyte antigen (HLA)-II, CD86, and PD-L2 expression directly contacted PD-1+ CTLA-4+ regulatory epidermis, indicating an axis tolerance a steady state. Environmental insults, ultraviolet B radiation...