A5076941013- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Immunotherapy and Immune Responses
- Inflammasome and immune disorders
- IL-33, ST2, and ILC Pathways
- Food Allergy and Anaphylaxis Research
- Gut microbiota and health
- Immune Response and Inflammation
- Atherosclerosis and Cardiovascular Diseases
- Bacterial Genetics and Biotechnology
- Vibrio bacteria research studies
- Clostridium difficile and Clostridium perfringens research
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Salmonella and Campylobacter epidemiology
ETH Zurich
2021-2025
Czech Academy of Sciences, Institute of Microbiology
2022
Massachusetts General Hospital
2020-2022
Center for Cancer Research
2022
Harvard University
2022
Leiden University
2018
Cancer immunology research is largely focused on the role of cytotoxic immune responses against advanced cancers. Herein, we demonstrate that CD4+ T helper (Th2) cells directly block spontaneous breast carcinogenesis by inducing terminal differentiation cancer cells. Th2 cell immunity, stimulated thymic stromal lymphopoietin, caused epigenetic reprogramming tumor cells, activating mammary gland and suppressing epithelial–mesenchymal transition. polarization was required for this...
Despite the remarkable successes of cancer immunotherapies, majority patients will experience only partial response followed by relapse resistant tumors. While treatment resistance has frequently been attributed to clonal selection and immunoediting, comparisons paired primary relapsed tumors in melanoma breast cancers indicate that they share clones. Here, we demonstrate both mouse models clinical human samples tumor cells evade immunotherapy generating unique transient cell-in-cell...
Abstract Endotoxin-driven systemic immune activation is a common hallmark across various clinical conditions. During acute critical illness, elevated plasma lipopolysaccharide triggers non-specific activation. In addition, compositional shift in the gut microbiota, including an increase gut-luminal opportunistic pathogens, observed. Whether causal link exists between endotoxemia and abundance of pathogens incompletely understood. Here, we model acute, pathophysiological concentrations mice...
Gasdermins (GSDMs) share a common functional domain structure and are best known for their capacity to form membrane pores. These pores hallmarks of specific cell death called pyroptosis mediate the secretion pro-inflammatory cytokines such as interleukin 1β (IL1β) 18 (IL18). Thereby, have been implicated in various immune responses against cancer infectious diseases acute Salmonella Typhimurium (S.Tm) gut infection. However, date, we lack comprehensive assessment different (GSDMA-E) during...
Abstract Salmonella enterica is a frequent cause of foodborne diseases, which attributed to its adaptability. Even within single host, expressing gene can be beneficial in certain infection stages but neutral or even detrimental others as previously shown for flagellins. Mutants deficient the conserved glycerol-3-phosphate and phosphate antiporter glpT have been positively selected nature, clinical, laboratory settings. This suggests that different selective pressures select presence absence...
Intestinal epithelial cell (IEC) NF-κB signaling regulates the balance between mucosal homeostasis and inflammation. It is not fully understood which signals tune this how bacterial exposure elicits process. Pure LPS induces activation in vivo. However, we found that mice, IECs do respond directly to LPS. Instead, tissue-resident lamina propria intercrypt macrophages sense via TLR4 rapidly secrete TNF elicit their immediate neighborhood. This response pattern relevant also during oral...
ABSTRACT Gasdermins (GSDMs) share a common functional domain structure and are best known for their capacity to form membrane pores. These pores hallmarks of specific cell death called pyroptosis mediate the secretion pro-inflammatory cytokines such as interleukin 1β (IL1β) 18 (IL18). Thereby, have been implicated in various immune responses against cancer infectious diseases acute Salmonella Typhimurium ( S .Tm) gut infection. However, date, we lack comprehensive assessment different...
Abstract Novel approaches in cancer immunotherapy have led to effective therapeutics against late-stage cancers. However, the role of immune system protection early-stage cancers remains uncertain. We previously discovered that thymic stromal lymphopoietin (TSLP) blocks early stages breast development through activation CD4+ T cells. TSLP is an epithelium-derived danger signal plays a key initiating response upon cell damage and stress. The aim this study investigate potential involvement...