A5050608357- Cancer Genomics and Diagnostics
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Renal cell carcinoma treatment
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Economic and Financial Impacts of Cancer
- Chronic Lymphocytic Leukemia Research
- Advanced Breast Cancer Therapies
- Palliative Care and End-of-Life Issues
- Brain Metastases and Treatment
- CAR-T cell therapy research
- Genetic factors in colorectal cancer
- Childhood Cancer Survivors' Quality of Life
- Monoclonal and Polyclonal Antibodies Research
- Chronic Myeloid Leukemia Treatments
- Immune Cell Function and Interaction
- Lung Cancer Research Studies
- Cancer survivorship and care
- COVID-19 and healthcare impacts
- Computational Drug Discovery Methods
- vaccines and immunoinformatics approaches
- Cancer Diagnosis and Treatment
Institut Gustave Roussy
2018-2025
Inserm
2020-2025
Centre de Recherche en Cancérologie de Marseille
2025
Centre National de la Recherche Scientifique
2025
Aix-Marseille Université
2025
Université Paris-Saclay
2021-2024
Institut Paoli-Calmettes
2024
Université Paris-Sud
2021-2022
Unité de recherche sur les maladies cardiovasculaires et métaboliques
2021
Sorbonne Université
2020-2021
Therapeutic drug monitoring (TDM) involves measuring and interpreting concentrations in biological fluids to adjust dosages. In onco-hematology, TDM guidelines for oral molecular targeted therapies (oMTTs) are varied. This study evaluates a quantitative approach with score predict the clinical usefulness of oMTTs. We identified key parameters an oMTT's suitability from standard recommendations. gathered oMTT pharmacological data, which covered exposure variability (considering...
Patients with cancer are at higher risk of severe coronavirus infectious disease 2019 (COVID-19), but the mechanisms underlying virus-host interactions during therapies remain elusive. When comparing nasopharyngeal swabs from and noncancer patients for RT-qPCR cycle thresholds measuring acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in 1063 (58% cancer), we found that malignant favors magnitude duration viral RNA shedding concomitant prolonged serum elevations type 1 IFN...
PURPOSE To facilitate implementation of precision medicine in clinical management cancer, the European Society Medical Oncology proposed 2018 a new scale to harmonize and standardize reporting interpretation clinically relevant genomics data (ESMO Scale Actionability molecular Targets [ESCAT]). This study aims characterize impact matching targetable genomic alterations (GAs) patients with advanced cancer according ESCAT. MATERIAL AND METHODS Analysis next-generation sequencing results from...
Cabozantinib is a tyrosine kinase inhibitor with substantial efficacy in metastatic renal cell carcinoma, and associated challenging toxicity profile leading to frequent drug discontinuations. Whereas an exposure/safety relationship was demonstrated for this drug, exposure/efficacy still unknown.We carried out monocentric, observational, pharmacokinetics/pharmacodynamics (PK/PD) study patients carcinoma (INDS MR 5612140520). We used measured blood concentrations of cabozantinib (Cmeas)...
Next-generation sequencing (NGS) assays based on plasma cell-free DNA (cfDNA) are increasingly used for clinical trials inclusion. Their optimized limit of detection applied to a large number genes leads the identification mutations not confirmed in tissue. It becomes essential describe characteristics and consequences these liquid biopsy-only mutations. In STING protocol (Gustave Roussy, NCT04932525), 542 patients with advanced solid cancer had cfDNA-based tissue-based NGS analysis...
Abstract Vaccination against coronavirus disease 2019 (COVID-19) relies on the in-depth understanding of protective immune responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We characterized polarity and specificity memory T cells directed SARS-CoV-2 viral lysates peptides determine correlates with spontaneous, virus-elicited, or vaccine-induced protection COVID-19 in disease-free cancer-bearing individuals. A disbalance between type 1 2 cytokine release was...
Tumor fraction at liquid biopsy was weakly correlated with the total tumor volume contrast-enhanced CT and did not accurately reflect burden CT.
Abstract Introduction Cabozantinib is an oral tyrosine kinase inhibitor that approved for the treatment of metastatic renal cell carcinoma (mRCC). a weak base exhibits pH-dependent solubility profile in vitro which raises concerns about its bioavailability patients treated with proton pump inhibitors (PPIs). The purpose this study was to investigate whether PPI use has impact on efficacy, safety, and residual concentration (Ctrough) cabozantinib mRCC. Materials Methods This retrospective...
Aging | doi:10.18632/aging.203525. Mélanie Bourgin, Lisa Derosa, Carolina Alves Costa Silva, Anne-Gaëlle Goubet, Agathe Dubuisson, François-Xavier Danlos, Claudia Grajeda-Iglesias, Luigi Cerbone, Arthur Geraud, Ariane Laparra, Fanny Aprahamian, Nitharsshini Nirmalathasan, Frank Madeo, Laurence Zitvogel, Guido Kroemer, Sylvère Durand
To report our experience of intercontinental multidisciplinary oncology videoconferencing between the French mainland and South Pacific to discuss rare and/or complex cancer cases.On first third Friday each month, all participants connected 6:30 am 8:00 GMT using a web conference service.Between November 2019 April 2020, 99 cases concerning 78 patients were discussed. Oncology subspecialties required sarcoma (n = 36), digestive 29), dermatology 5), gynecology breast urology hematology ENT...