A5069687125- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Forensic Toxicology and Drug Analysis
- Cannabis and Cannabinoid Research
- SARS-CoV-2 detection and testing
- Long-Term Effects of COVID-19
- Alcohol Consumption and Health Effects
- Monoclonal and Polyclonal Antibodies Research
- Renal Transplantation Outcomes and Treatments
- Epilepsy research and treatment
- Metabolism and Genetic Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Enzyme Production and Characterization
- Pharmacological Effects and Toxicity Studies
- Advanced Biosensing Techniques and Applications
- COVID-19 epidemiological studies
- Thyroid Disorders and Treatments
- Signaling Pathways in Disease
- Glycosylation and Glycoproteins Research
- Neuroscience of respiration and sleep
- Viral Infections and Outbreaks Research
- Immunodeficiency and Autoimmune Disorders
- Biofuel production and bioconversion
- Peptidase Inhibition and Analysis
- Myasthenia Gravis and Thymoma
Mount Sinai Hospital
2021-2024
Icahn School of Medicine at Mount Sinai
2020-2024
Mount Sinai Health System
2020-2021
Memorial Sloan Kettering Cancer Center
2014-2017
Montefiore Medical Center
2017
National Institute on Drug Abuse
2013-2014
National Institutes of Health
2014
Georgetown University
2006-2011
Georgetown-Howard Universities Center for Clinical and Translational Science
2011
Georgetown University Medical Center
2010
SARS-CoV-2 antibodies persist As the number of daily COVID-19 cases continues to mount worldwide, nature humoral immune response severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains uncertain. Wajnberg et al. used a cohort more than 30,000 infected individuals with mild moderate symptoms determine robustness and longevity anti–SARS-CoV-2 antibody response. They found that neutralizing titers against spike protein persisted for at least 5 months after infection. Although...
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a new human with few effective treatments1. Convalescent plasma, donated persons who have recovered from COVID-19, the acellular component of blood that contains antibodies, including those specifically recognize SARS-CoV-2. These when transfused into patients infected SARS-CoV-2, are thought to exert an antiviral effect, suppressing virus replication before mounted their own...
Abstract SARS-CoV-2 has caused a global pandemic with millions infected and numerous fatalities. Questions regarding the robustness, functionality longevity of antibody response to virus remain unanswered. Here we report that vast majority individuals mild-to-moderate COVID-19 experience robust IgG responses against viral spike protein, based on dataset 19,860 screened at Mount Sinai Health System in New York City. We also show titers are stable for least period approximating three months,...
Background Since December 2019, Coronavirus Disease 2019 (COVID-19) has become a global pandemic, causing mass morbidity and mortality. Prior studies in other respiratory infections suggest that convalescent plasma transfusion may offer benefit to some patients. Here, the outcomes of thirty-nine hospitalized patients with severe life-threatening COVID-19 who received were compared against cohort retrospectively matched controls. Methods Plasma recipients selected based on supplemental oxygen...
The COVID-19 pandemic caused by infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has led to more than 100,000 deaths in the United States. Several studies have revealed that hyper-inflammatory response induced SARS-CoV-2 is a major cause of disease severity and death infected patients. However, predictive biomarkers pathogenic inflammation help guide targetable immune pathways are critically lacking. We implemented rapid multiplex cytokine assay measure serum IL-6,...
Abstract Passive transfer of antibodies from COVID-19 convalescent patients is being used as an experimental treatment for eligible with SARS-CoV-2 infections. The United States Food and Drug Administration’s (FDA) guidelines plasma initially recommended target antibody titers 160. We evaluated neutralizing in sera recovered using plaque reduction neutralization tests (PRNT) at moderate (PRNT50) high (PRNT90) stringency thresholds. found that activity significantly increased time post...
Clinical Implications•We describe 3 patients with X-linked agammaglobulinemia coronavirus disease 2019 who failed supportive treatment but recovered after receiving convalescent plasma. •We The (COVID-19) pandemic has presented a global challenge. pathogenesis of severe acute respiratory syndrome 2 (SARS-CoV-2) infection is complex, and effective therapy currently lacking. Convalescent plasma transfusion safe under investigation for effectiveness.1Bloch E.M. Shoham S. Casadevall A. Sachais...
Background: SARS-CoV-2 antibody testing is important for understanding immunity prevalence, and may have implications healthcare workers (HCW) during the pandemic. Methods: We conducted immunologic of to determine prevalence IgG in this population. HCW were advised wait at least two weeks from time symptom onset or suspected exposure before undergoing testing. All participants self-reported asymptomatic three days Results: Two hundred eighty-five samples collected March 24, 2020 April 4,...
Accurate measurement of free thyroxine (FT(4)) is important for diagnosing and managing thyroid disorders. Most laboratories measure FT(4) by direct analogue immunoassay methods. The validity these methods have recently been questioned. inverse log-linear relationship between thyroid-stimulating hormone (TSH) well described provides a physiological rationale on which to base an evaluation assays.The study included 109 participants whom was requested their clinician. Samples were selected...
Ewing sarcoma family of tumors (ESFT) is a group aggressive pediatric malignancies driven by the EWS-FLI1 fusion protein, an aberrant transcription factor up-regulating specific target genes, such as neuropeptide Y (NPY) and its Y1 Y5 receptors (Y5Rs). Previously, we have shown that both exogenous NPY endogenous stimulate ESFT cell death via Y5Rs. Here, demonstrate this effect prevented dipeptidyl peptidases (DPPs), which cleave to shorter form, NPY(3-36), not active at Y1Rs. We NPY-induced...
Oral fluid (OF) is an increasingly popular alternative matrix for drug testing, with cannabinoids being the most commonly identified illicit drug. Quantification of multiple OF and understanding differences in cannabinoid pharmacokinetics between frequent occasional smokers improve test interpretation. The new Oral‐Eze® collection device has elution buffer that stabilizes analytes improves recovery from pad; however, its performance not been independently evaluated. After controlled smoking...
Background: Biotin has been reported to interfere with several commonly used laboratory assays resulting in misleading values and possible erroneous diagnosis treatment. This report describes a prospective study of biotin interference thyroid-related assays, comparison different assay platforms. Materials Methods: Thirteen adult subjects (mean age 45 ± 13 years old) were administered 10 mg/day for eight days. Blood specimens collected at three time points on day 1 8 (baseline, two, five...
SeroNet institutions have developed or implemented 61 diverse COVID-19 serological assays and are collaboratively working to harmonize these using reference materials establish standardized reporting units. This will facilitate clinical interpretation of serology results cross-comparison research data.
Solid organ transplant (SOT) recipients may have a suboptimal humoral immune response to the coronavirus disease 2019 (COVID-19) vaccine, prompting need for additional doses of vaccine immunocompromised patients. However, data regarding responses vaccination specifically in SOT with well controlled HIV are lacking. We conducted prospective observational cohort single-center study and without HIV-1 who had received two mRNA COVID-19 were planning receive doses. Severe acute respiratory...