A5068762264- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Amyotrophic Lateral Sclerosis Research
- Liver Disease and Transplantation
- Neurogenetic and Muscular Disorders Research
- HIV/AIDS drug development and treatment
- Parkinson's Disease Mechanisms and Treatments
- Cervical Cancer and HPV Research
- Retinal Diseases and Treatments
- Genetic Neurodegenerative Diseases
- Congenital Heart Disease Studies
- Hepatitis Viruses Studies and Epidemiology
- Systemic Lupus Erythematosus Research
- Organ Transplantation Techniques and Outcomes
- Retinal Imaging and Analysis
- HIV/AIDS Research and Interventions
- Glaucoma and retinal disorders
- Infant Nutrition and Health
- Antifungal resistance and susceptibility
- Hepatocellular Carcinoma Treatment and Prognosis
- Neonatal Respiratory Health Research
- Glioma Diagnosis and Treatment
- Cervical and Thoracic Myelopathy
- Colorectal and Anal Carcinomas
Hospices Civils de Lyon
2016-2025
Inserm
2013-2024
Hôpital de la Croix-Rousse
2015-2024
Centre National de la Recherche Scientifique
2013-2024
Sorbonne Université
2015-2024
Pitié-Salpêtrière Hospital
2015-2024
Assistance Publique – Hôpitaux de Paris
2002-2024
Laboratoire d’Imagerie Biomédicale
2014-2024
Hôpital Edouard Herriot
2007-2024
Université Claude Bernard Lyon 1
2012-2023
Hepatocellular carcinoma (HCC) risk-scores may predict HCC in Asian entecavir (ETV)-treated patients. We aimed to study risk factors and performance of scores during ETV treatment an ethnically diverse Western population.We studied all HBV monoinfected patients treated with from 11 European referral centres within the VIRGIL Network.A total 744 were included; 42% Caucasian, 29% Asian, 19% other, 10% unknown. At baseline, 164 (22%) had cirrhosis. During a median follow-up 167 (IQR 82-212)...
Despite being one of the most devastating diseases known, there is little evidence for diagnosing and managing patients with amyotrophic lateral sclerosis (ALS). Although specific therapy lacking, correct early diagnosis introduction symptomatic can have a profound influence on care quality life patient may increase survival time. This document addresses optimal clinical approach to ALS. The final literature search was performed in spring 2005. Consensus recommendations are given graded...
The aim of this retrospective study was to determine the predictive value alanine aminotransferase (ALT) levels for histologic findings in patients with chronic hepatitis C virus (HCV) infection. Data on 864 HCV RNA-positive were collected. ALT values obtained at time biopsy (before treatment), and normal defined as serial evaluations during a 6-month period. Histologic results scored using METAVIR system. Among all patients, 99% those elevated had score least F1 (positive [PPV], 99%) 88%...
External acuminata condylomata (EAC) are among the most common sexually transmitted diseases. Although it is understood that low-risk human papillomavirus (HPV) genotypes 6 and 11 associated with EAC, there have only been a few, small, published studies reporting genotype-specific prevalence of HPV. The objective our study was to assess HPV for large number cases involving both men women evaluate potential benefit quadrivalent (genotypes 6, 11, 16, 18) vaccine in France.A total 256 260 who...
Abstract: Only 20% of patients with chronic hepatitis C (CHC) will develop cirrhosis, and fibrosis progression remains highly unpredictable. A recent genome-wide association study identified a genetic variant in the patatin-like phospholipase-3 (PNPLA3) gene (rs738409 C>G) associated steatosis that was further demonstrated to influence severity nonalcoholic fatty liver disease. The aim this assess impact polymorphism on histological damage response antiviral therapy CHC. We recruited 537...
Entecavir (ETV) is a potent inhibitor of viral replication in nucleos(t)ide analogue (NA)-naïve chronic hepatitis B (CHB) patients. The aim this study was to investigate the long term efficacy and safety ETV NA-naïve CHB patients, particularly those with detectable virus (HBV) DNA after 48 weeks, whom treatment adaptation suggested by current guidelines. In multicenter cohort study, we investigated 333 patients treated entecavir monotherapy. population consisted 243 whereas 90 were...
Abstract Anal cancer is a rare but its incidence increasing. Human papillomavirus (HPV) infection seems to be associated with the occurrence of most cases. The genotype‐specific prevalence HPV in anal was estimated assess potential benefit vaccination France. histological specimens were retrospectively recruited 2008 from 16 French centres and centrally tested for genotyping using INNO‐LiPA assay allowing detection 28 genotypes. Results analyzed according age, gender, HIV status when...
The aim of this study was to investigate the extent cortical and subcortical lesions in amyotrophic lateral sclerosis (ALS) using, combination, voxel based diffusion tensor imaging (DTI) morphometry (VBM). We included 15 patients with definite or probable ALS 25 healthy volunteers. Patients were assessed using revised Functional Rating Scale (ALSFRS-R). In patients, reduced fractional anisotropy found bilateral corticospinal tracts, left insula/ventrolateral premotor cortex, right parietal...
Abstract Accurate patient stratification into prognostic categories and targeting Amyotrophic Lateral Sclerosis (ALS)-associated pathways may pave the way for promising trials. We evaluated blood-based indicators using an array of pathological markers. Plasma samples were collected as part a large, phase III clinical trial (Mitotarget/TRO19622) at months 1, 6, 12 18. The ALSFRS-r score was used proxy disease progression to assess predictive value candidate biological indicators. First,...
Considerable functional reorganization takes place in amyotrophic lateral sclerosis (ALS) face of relentless structural degeneration. This study evaluates adaptation ALS patients with lower motor neuron predominant (LMNp) and upper (UMNp) dysfunction.Seventeen LMNp patients, 14 UMNp controls participated a magnetic resonance imaging study. Study-group-specific activation patterns were evaluated during preparation for task. Connectivity analyses carried out using the supplementary area (SMA),...
Abstract BACKGROUND The possible association between oral cleft in the newborn and maternal exposure to corticoids during pregnancy is still controversial. aim of this study was test by a case‐control analysis using large multicentric MADRE database. METHODS database collection information on malformed infants with history first‐trimester drug exposure. Nine malformation registries participate data collection. Cases were defined as presenting palate or lip, use corticosteroids first...
The identification of mutations in the TARDBP and more recently FUS gene as cause amyotrophic lateral sclerosis (ALS) is providing field with new insight about mechanisms involved this severe neurodegenerative disease.To extend these recent genetic reports, we screened entire a cohort 200 patients ALS. An additional 285 sporadic ALS were for variants exon 15 which previously reported.In total, 3 different identified 4 patients, including 1 3-bp deletion patient 2 missense familial ALS.Our...
Abstract Occult hepatitis B virus (HBV) infection is common in chronic C patient. However, its significance and consequences are still unclear. The aim of this study was to evaluate the prevalence occult HBV among HCV carriers France assess impact on liver histology response antiviral therapy. To end a cohort 203 patients with without surface antigen (HBsAg) has been examined. Serum HBV‐DNA detected using highly sensitive PCR primers located S X genes. viraemia levels were further determined...
To describe the phenotype and phenotype-genotype correlations in patients with amyotrophic lateral sclerosis (ALS) TARDBP gene mutations.French TARDBP+ ALS (n = 28) were compared first to 3 cohorts: 737 sporadic (SALS), 192 nonmutated familial (FALS), 58 SOD1 + FALS, then 117 cases from literature. Genotype-phenotype studied for most frequent mutations.In patients, onset was earlier (p 0.0003), upper limb (UL) predominant 0.002), duration longer 0.0001) than SALS. SOD1+ groups had longest...
Abstract Background and Aims Arrival of direct‐acting antiviral agents against hepatitis C virus with high‐sustained virological response rates very few side effects has drastically changed the management infection. The impact exposure on hepatocellular carcinoma recurrence after a first remission in patients advanced fibrosis remains to be clarified. Methods 68 consecutive diagnosis under remission, subsequently treated or not combination, were included. Clinical, biological data collected...
Sexually transmitted acute hepatitis C virus (HCV) infections (AHIs) have been mainly described in human immunodeficiency (HIV)-infected men who sex with (MSM). Cases HIV-negative MSM are scarce. We describe the epidemic of AHI HIV-infected and Lyon, France.All cases diagnosed Lyon University Hospital from 2014 to 2017 were included. incidence was determined preexposure prophylaxis (PrEP)-using MSM. Transmission clusters identified by construction phylogenetic trees based on HCV NS5B...