A5048233618- Acute Ischemic Stroke Management
- Acute Myocardial Infarction Research
- Healthcare Systems and Practices
- Clinical practice guidelines implementation
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Fibrosis and Remodeling
- Cardiac Ischemia and Reperfusion
- Cerebrovascular and Carotid Artery Diseases
- Atrial Fibrillation Management and Outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
- Heart Failure Treatment and Management
- Signaling Pathways in Disease
- Venous Thromboembolism Diagnosis and Management
- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Stroke Rehabilitation and Recovery
- Healthcare Quality and Management
- Cardiac Arrest and Resuscitation
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac tumors and thrombi
- Chronic Disease Management Strategies
- Healthcare Systems and Reforms
- Traumatic Brain Injury and Neurovascular Disturbances
- Electronic Health Records Systems
Hôpital Louis Pradel
2014-2024
Hospices Civils de Lyon
2016-2024
Inserm
2019-2024
Université Claude Bernard Lyon 1
2016-2024
Lyon College
2022
Centre National de la Recherche Scientifique
2020-2022
Lille’s Cardiology Hospital
2022
Laboratoire CarMeN
2020
Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
2020
Centre Léon Bérard
2015-2017
In the COVERT-MI randomised placebo-controlled trial, oral administration of high-dose colchicine at time reperfusion and for 5 days in acute ST-elevated myocardial infarction did not reduce infarct size but was associated with a significant increase left ventricular thrombus (LVT) comparison to placebo. We aimed assess 1-year clinical outcomes study population.
Objective To assess the relationship between matrix metalloproteinase 9 (MMP-9), a proteolytic enzyme involved in breakdown of blood-brain barrier, and infarct growth hemorrhagic transformation ischemic stroke with large vessel occlusion (LVO) era mechanical thrombectomy (MT) using kinetics MMP-9 sequential magnetic resonance imaging (MRI). Methods HIBISCUS-STROKE is cohort study including patients admitted for an LVO treated MT following admission MRI. Patients underwent assessment MMP-9,...
Since the onset of pandemic, only few studies focused on longitudinal immune monitoring in critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS) whereas their hospital stay may last for several weeks. Consequently, question whether parameters drive or associate delayed unfavorable outcome these remains unsolved. We present a dynamic description immuno-inflammatory derangements 64 including plasma IFNα2 levels and IFN-stimulated genes (ISG) score measurements. ARDS...
In ischemic stroke, inflammatory status may condition the development of collateral circulation. Here we assessed relationship between systemic biomarkers and in large vessel occlusion before mechanical thrombectomy.HIBISCUS-STROKE is a cohort study including acute stroke patients with treated thrombectomy following admission magnetic resonance imaging. MMP-9 (matrix metalloproteinase-9) MCP-1 (monocyte chemoattractant protein-1) were measured on blood sampling collected at admission....
To assess whether interleukin-6 (IL-6) level is a marker of futile reperfusion in patients with acute ischemic stroke (AIS) large vessel occlusion treated mechanical thrombectomy (MT).The Cohort Patients to Identify Biological and Imaging Markers Cardiovascular Outcomes Stroke (HIBISCUS-STROKE) includes AIS MT after MRI. We performed sequential assessment IL-6 (admission, 6 hours, 24 48 hours 3 months from admission). Among successful (Thrombolysis Cerebral Infarction scale 2b/3), was...
Myocardial hemorrhage (IMH) and persistent microvascular obstruction (MVO) are associated with impaired myocardial recovery adverse clinical outcomes in STEMI patients. However, their relationship circulating inflammatory biomarkers is unclear human patients.Twenty consecutive patients referred for primary percutaneous coronary intervention of first were included a prospective study. Blood sampling was performed at admission, 4, 12, 24, 48 hours, 7 30 days after reperfusion biomarker (C...
Using a translational approach with an ST-segment myocardial infarction (STEMI) cohort and mouse model of infarction, we highlighted the role secreted IL-6 MCP-1 cytokines STAT3 pathway in heart macrophage recruitment activation. Cardiac myocytes secrete response to hypoxic stress, leading and/or polarization anti-inflammatory macrophages via pathway. In our preclinical neutralization or reduced infarct size. Together, data demonstrate that can be deleterious acute phase STEMI.
Diastolic dysfunction is frequent in patients with type 2 diabetes mellitus (DM2) and associated a poor prognosis. This study aimed to describe diastolic function changes over time DM2 identify predictive factors of deterioration.Diastolic was assessed by echocardiography according the EACVI/ASE recommendations at baseline 3-year follow-up prospective cohort 310 without overt heart disease. Predictors deterioration were identified using logistic regression analysis. During follow-up,...
Abstract Choroid plexus (ChPs) are involved in the early inflammatory response that occurs many brain disorders. However, activation of immune cells within ChPs to neuroinflammation is still largely unexplored in-vivo . There therefore a crucial need for developing imaging tool would allow non-invasive monitoring ChP involvement these diseases. Magnetic resonance (MRI) coupled with superparamagnetic particles iron oxide (SPIO) minimally invasive technique allowing track phagocytic Our aim...
The purpose of this study is to propose and validate a preclinical in vivo magnetic resonance imaging (MRI) tool monitor neuroinflammation following ischemic stroke, based on injection novel multimodal nanoprobe, NanoGd, specifically designed for internalization by phagocytic cells. First, it verified that NanoGd efficiently internalized microglia vitro. In MRI coupled with intravenous permanent middle cerebral artery occlusion mouse model results hypointense signals the lesion. these mice,...
Abstract Background Type 2 diabetes (T2D) is a frequent comorbidity encountered in patients with severe aortic stenosis (AS), leading to an adverse left ventricular (LV) remodeling and dysfunction. Metabolic alterations have been suggested as contributors of the deleterious effect T2D on LV function AS, but so far, underlying mechanisms remain unclear. Mitochondria play central role regulation cardiac energy metabolism. Objectives We aimed explore mitochondrial associated preserved ejection...
Abstract Reperfusion is the only existing strategy for patients with acute ischemic stroke, however it causes further brain damage itself. A feasible therapy targeting reperfusion injury remote conditioning (RIC). This was a two-centre, randomized, blinded international study, using translational imaging endpoints, aimed to examine neuroprotective effects of RIC in stroke model. 80 male rats underwent 90-min middle cerebral artery occlusion. consisted 4 × 5 min cycles left hind limb...
Background: As inflammation following ST-segment elevation myocardial infarction (STEMI) is both beneficial and deleterious, there a need to find new biomarkers of STEMI severity. Objective: We hypothesized that the circulating concentration soluble tumor necrosis factor α receptors 1 2 (sTNFR1 sTNFR2) might predict clinical outcomes in patients. Methods: enrolled into prospective cohort 251 consecutive patients referred our hospital for percutaneous coronary intervention revascularization....
Aging is associated with a chronic low-grade inflammatory state. This condition may affect the acute response involved in ST-segment-elevation myocardial infarction (STEMI) or ischemic stroke (AIS). We sought to compare profile of set circulating markers between young and older patients admitted for STEMI AIS.HIBISCUS-STEMI (Cohort Patients Identify Biological Imaging Markers Cardiovascular Outcomes ST Elevation Myocardial Infarction) HIBISCUS-STROKE Stroke) are 2 cohort studies that...
Abstract Background Soluble vascular cell adhesion molecule‐1 (sVCAM‐1) is a biomarker of endothelial activation and inflammation. There still controversy as to whether it can predict clinical outcome after ST‐elevation myocardial infarction (STEMI). Our aim was assess the sVCAM‐1 kinetics evaluate its prognostic predictive value. Method We prospectively enrolled 251 consecutive STEMI patients who underwent coronary revascularization in our university hospital. Blood samples were collected...