A5067440768- Advanced MRI Techniques and Applications
- Acute Ischemic Stroke Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Barrier Structure and Function Studies
- Cerebrovascular and Carotid Artery Diseases
- Advanced X-ray Imaging Techniques
- Neurological Disease Mechanisms and Treatments
- MRI in cancer diagnosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Medical Imaging Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Photoacoustic and Ultrasonic Imaging
- Cardiac Imaging and Diagnostics
- Brain Tumor Detection and Classification
- Advanced Electron Microscopy Techniques and Applications
- Alzheimer's disease research and treatments
- S100 Proteins and Annexins
- Atomic and Subatomic Physics Research
- Cardiac Ischemia and Reperfusion
- Cell Image Analysis Techniques
- Advanced X-ray and CT Imaging
- Intracerebral and Subarachnoid Hemorrhage Research
- Nanoplatforms for cancer theranostics
- Tissue Engineering and Regenerative Medicine
Laboratoire CarMeN
2017-2025
Université Claude Bernard Lyon 1
2015-2025
Institut National des Sciences Appliquées de Lyon
2015-2025
Inserm
2016-2025
Hospices Civils de Lyon
2008-2025
Centre National de la Recherche Scientifique
2014-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2017-2025
Lyon College
2021-2024
Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
2008-2022
Institut National de la Recherche Agronomique
2021
The intensity of the inflammatory response may be related to volume acute infarction. Ultra-small superparamagnetic particles iron oxide (USPIO) enable assessment neuroinflammation. We aimed assess whether might subacute ischemic lesion volume.We enrolled patients who presented with anterior circulation stroke. MRI was performed at day 0, 6, and 9. protocol included T1-weighted imaging, gradient-echo T2*-weighted diffusion-weighted perfusion-weighted imaging MR angiography. Blood-brain...
Due to its poor capacity for regeneration, the heart is particularly sensitive loss of contractile cardiomyocytes. The onslaught damage caused by ischaemia and reperfusion, occurring during an acute myocardial infarction subsequent reperfusion therapy, can wipe out upwards a billion A similar program cell death cause irreversible neurons in ischaemic stroke. Similar pathways lethal injury contribute other pathologies such as left ventricular dysfunction failure cancer therapy. Consequently,...
A growing body of evidence suggests that inflammatory processes are involved in the pathophysiology stroke. Phagocyte cells, involving resident microglia and infiltrating macrophages, secrete both protective toxic molecules thus represent a potential therapeutic target. The aim present study was to monitor phagocytic activity after focal cerebral ischemia mice.Ultrasmall superparamagnetic particles iron oxide (USPIO) were intravenously injected permanent middle artery occlusion monitored by...
The choroid plexuses (ChPs) perform indispensable functions for the development, maintenance and functioning of brain. Although they have gained considerable interest in last years, their involvement brain disorders is still largely unknown, notably because deep location inside hampers non-invasive investigations. In-vivo iImaging tools become instrumental to diagnosis pathophysiological study neurological neuropsychiatric diseases. This review summarizes knowledge that has been gathered...
Abstract Purpose To characterize and compare hepatocellular carcinoma liver metastases of colorectal metastatic cancer (CMC) by means quantitative perfusion MRI. Materials Methods Liver was assessed in 26 HCC CMC patients (50 nodules) contrast‐enhanced Six parameters—hepatic index ( HPI ), mean transit time MTT distribution volume DV total blood flow F T arterial A portal P )—were calculated tumor nodules the adjacent hepatic parenchyma. Results The values , were significantly higher than...
MR signal changes after intravenous ultrasmall superparamagnetic iron oxide (USPIO) injection are related to inflammatory cells at the subacute stages focal cerebral injury. However, early stages, interpretation of USPIO-related alterations remains controversial. Here, we compared USPIO with histological and macrophage distribution during first 24 hours in a rodent model acute stroke.Multiparametric MRI 7T were confronted from 6 permanent middle artery occlusion mice. Blood-brain barrier...
The inflammatory response following ischemic stroke is dominated by innate immune cells: resident microglia and blood-derived macrophages. ambivalent role of these cells in outcome might be explained part the acquisition distinct functional phenotypes: classically (M1) alternatively activated (M2) To shed light on crosstalk between hypoxic neurons macrophages, an vitro model was set up which bone marrow-derived macrophages were co-cultured with hippocampal slices subjected to oxygen glucose...
Microvascular dysfunction and no-reflow are considered a major cause of secondary damage despite revascularization in acute ischemic stroke (AIS), ultimately affecting patient outcomes. We used quantitative PET-MRI imaging to characterize early microvascular damages preclinical non-human primate model mimicking endovascular mechanical thrombectomy (EVT). During occlusion, PET perfusion MRI diffusion were measure lesion core volumes respectively. Following revascularization, multiparametric...
Rationale: Osteoarthritis (OA) is a degenerative disease affecting cartilage, synovium and bone, that major cause of pain disability. Intra-articular injection hyaluronic acid (HA) derivatives, also known as viscosupplementation (VS), common treatment for the symptomatic management knee OA. Despite its widespread use, magnitude clinical benefit VS remains controversial, with conflicting results due to methodological differences possible in efficacy between products related remanence...
This study attempted to assess the accuracy and potential of lung magnetic resonance (MR) perfusion imaging compared with scintigraphy in evaluation patients suspected defects. The technique, which uses an inversion recovery turbo-FLASH sequence ultra-short TE (1.4 msec), was tested 24 clinically having acute pulmonary embolism (n = 19) severe emphysema 5). Perfusion performed within 48 hours prior MRI examination both groups patients. dynamic acquired coronal plane consisted 10 images 6...
Prediction of hemorrhagic transformation (HT) in patients treated by intravenous recombinant tissue-type plasminogen activator (rt-PA) is a challenging issue acute stroke management. HT may be correlated with severe hypoperfusion. Signal changes observed at susceptibility-weighted magnetic resonance imaging (MRI) within large perfusion defects. A signal drop cerebral veins T2∗-weighted gradient-echo MRI expected ischemia, and indicate subsequent risk HT. The authors prospectively searched...
Peroxisome proliferator-activated receptors (PPARs) are a potential target for neuroprotection in focal ischemic stroke. These nuclear have major effects lipid metabolism, but they also involved inflammatory processes. Three PPAR isotypes been identified: alpha, beta (or delta) and gamma. The development of transgenic mice offers promising tool prospective therapeutic studies. This study used MRI to assess the role PPARalpha PPARbeta Permanent middle cerebral artery occlusion induced...
Epidemiologic studies report cardiovascular protection conferred by omega-3 fatty acids, in particular docosahexaenoic acid (DHA). However, few experimental have addressed its potential acute stroke treatment. The present study used multimodal MRI to assess vivo the neuroprotection DHA and a brain-targeting form of DHA-containing lysophosphatidylcholine (AceDoPC) stroke. Rats underwent intraluminal middle cerebral artery occlusion (MCAO) were treated at reperfusion intravenous injection i)...
Abstract Choroid plexus (ChPs) are involved in the early inflammatory response that occurs many brain disorders. However, activation of immune cells within ChPs to neuroinflammation is still largely unexplored in-vivo . There therefore a crucial need for developing imaging tool would allow non-invasive monitoring ChP involvement these diseases. Magnetic resonance (MRI) coupled with superparamagnetic particles iron oxide (SPIO) minimally invasive technique allowing track phagocytic Our aim...
Rationale & aim: Various types of cell therapies are currently under investigation for the treatment ischemic stroke patients.To bridge gap between administration and therapeutic outcome, there is a need non-invasive monitoring these innovative approaches.Spectral photon counting computed tomography (SPCCT) new imaging modality that may be suitable tracking.SPCCT next generation clinical CT allows selective visualization quantification multiple contrast agents.The aims this study are: (i) to...
In an acute ischaemic stroke, understanding the dynamics of blood-brain barrier injury is particular importance for prevention symptomatic haemorrhagic transformation. However, available techniques assessing permeability are not quantitative and little used in context reperfusion therapy. Nanoparticles cross healthy or impaired through combined passive active processes. Imaging quantifying their transfer rate could better characterize damage refine delivery neuroprotective agents. We...
The purpose of this study is to propose and validate a preclinical in vivo magnetic resonance imaging (MRI) tool monitor neuroinflammation following ischemic stroke, based on injection novel multimodal nanoprobe, NanoGd, specifically designed for internalization by phagocytic cells. First, it verified that NanoGd efficiently internalized microglia vitro. In MRI coupled with intravenous permanent middle cerebral artery occlusion mouse model results hypointense signals the lesion. these mice,...
Microglia exhibit diverse morphologies reflecting environmental conditions, maturity or functional states. Thus, morphological characterization provides important information to understand microglial roles and functions. Most recent analysis relies on classifying cells based parameters. However, this classification may lack biological relevance, as represent a continuum rather than distinct, separate groups, do not correspond mathematically defined, clusters irrelevant of function. Instead,...
Microglia exhibit diverse morphologies reflecting environmental conditions, maturity, or functional states. Thus, morphological characterization provides important information to understand microglial roles and functions. Most recent analysis relies on classifying cells based parameters. However, this classification may lack biological relevance, as represent a continuum rather than distinct, separate groups, do not correspond mathematically defined clusters irrelevant of function. Instead,...