A5068874255- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Imaging and Diagnostics
- Photoacoustic and Ultrasonic Imaging
- Advanced MRI Techniques and Applications
- Systemic Sclerosis and Related Diseases
- Medical Imaging and Pathology Studies
- Sarcoidosis and Beryllium Toxicity Research
- Occupational and environmental lung diseases
- Dental Radiography and Imaging
- Venous Thromboembolism Diagnosis and Management
- Tracheal and airway disorders
- Occupational exposure and asthma
- Vascular Anomalies and Treatments
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Ultrasound in Clinical Applications
- Radiomics and Machine Learning in Medical Imaging
- Aortic aneurysm repair treatments
- Inflammatory Myopathies and Dermatomyositis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Infrared Thermography in Medicine
Centre National de la Recherche Scientifique
2017-2025
Hôpital Louis Pradel
2015-2025
Hospices Civils de Lyon
2017-2025
Inserm
2017-2025
Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
2017-2025
Université Claude Bernard Lyon 1
2015-2025
Institut National des Sciences Appliquées de Lyon
2017-2025
University of Lausanne
2024-2025
Université de Lyon
2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2024
Abstract Computed tomography (CT) is one of the most commonly used clinical imaging modalities. There have recently been many reports novel contrast agents for CT imaging. In particular, development gold nanoparticles (AuNP) as a topic intense interest. AuNP favorable characteristics this application such high payloads generating material, strong X-ray attenuation, excellent biocompatibility, tailorable surface chemistry, and tunable sizes shapes. However, there conflicting on role size...
Background Spatial resolution, soft-tissue contrast, and dose-efficient capabilities of photon-counting CT (PCCT) potentially allow a better quality diagnostic confidence coronary angiography (CCTA) in comparison to conventional CT. Purpose To compare the CCTA scans obtained with clinical prototype PCCT system an energy-integrating detector (EID) dual-layer (DLCT) system. Materials Methods In this prospective board-approved study informed consent, participants artery disease underwent...
In patients with chronic fibrosing interstitial lung disease (ILD), a progressive phenotype (PF-ILD) may develop, but information on the frequency and characteristics of this population outside clinical trials is lacking. We assessed outcomes PF-ILD other than idiopathic pulmonary fibrosis (IPF) in real-world, single-centre cohort. The files all consecutive adult ILD (2010–2017) were examined retrospectively for pre-defined criteria ≥10% high-resolution computed tomography during overlapping...
Computed tomography (CT) is an X-ray-based medical imaging technique commonly used for noninvasive gastrointestinal tract (GIT) imaging. Iodine- and barium-based CT contrast agents are in the clinic GIT imaging; however, inflammatory bowel disease (IBD) challenging since iodinated not specific sites of inflammation. Cerium oxide nanoparticles (CeNP) can produce strong X-ray attenuation due to cerium's k-edge at 40.4 keV but have yet been explored In addition, we hypothesized that use dextran...
A new prototype spectral photon-counting computed tomography (SPCCT) based on a modified clinical CT system has been developed. SPCCT analysis of the energy composition transmitted x-ray spectrum potentially allows simultaneous dual contrast agent imaging, however, this not yet demonstrated with such system. We investigated feasibility using to distinguish gold nanoparticles (AuNP) and an iodinated agent. The agents calcium phosphate were imaged in phantoms. Conventional CT, K-edge, iodine...
A new spectral photon-counting CT prototype has the potential for non-invasive quantitative determination of gold nanoparticle biodistribution <italic>in vivo</italic> over time.
Abstract Spectral photon-counting computed tomography (SPCCT) is a rapidly emerging imaging modality that provides energy-dependent information on individual x-ray photons, leading to accurate material decomposition and simultaneous quantification of multiple contrast generating materials. Development SPCCT-specific agents needed overcome the issues with currently used iodinated agents, such as difficulty in differentiation from calcified structures, yield SPCCT’s full promise. In this...
After endovascular aortic repair (EVAR), discrimination of endoleaks and intra-aneurysmatic calcifications within the aneurysm often requires multiphase computed tomography (CT). Spectral photon-counting CT (SPCCT) in combination with a two-contrast agent injection protocol may provide reliable detection single acquisition. To evaluate feasibility SPCCT, stent-lined compartment an abdominal phantom was filled mixture iodine gadolinium mimicking enhanced blood. represent different flow rates,...
Background Macrophage burden is a major factor in the risk of atherosclerotic plaque rupture, and its evaluation remains challenging with molecular noninvasive imaging approaches. Photon-counting CT (PCCT) k-edge aims to allow for specific detection macrophages using gold nanoparticles. Purpose To perform combination nanoparticles detect quantify macrophage within aortas rabbits. Materials Methods Atherosclerotic control New Zealand white rabbits were imaged before at several time points up...
Objectives In-stent restenosis (ISR) is one of the main long-term complications after coronary stent placement, and ability to evaluate ISR noninvasively using computed tomography (CT) angiography remains challenging. For this application, spectral photon-counting CT (SPCCT) has potential increase image quality reduce artifacts due its advanced detector technology. Our study aimed verify technical clinical a novel SPCCT prototype an phantom setup. Materials Methods Soft plaque-like (45 HU;...
To evaluate the feasibility of multicolour quantitative imaging with spectral photon-counting computed tomography (SPCCT) different mixed contrast agents.Phantoms containing eleven tubes mixtures varying proportions two agents (i.e. selected from gadolinium, iodine or gold nanoparticles) were prepared so that attenuation each tube was about 280 HU. Scans acquired at 120 kVp and 100 mAs using a five-bin preclinical SPCCT prototype, generating conventional, water, iodine, gadolinium images....
Abstract Diagnostic imaging of hepatocellular carcinoma (HCC) requires a liver CT or MRI multiphase acquisition protocol. Patients would benefit from high-resolution method capable performing multi-phase in single without an increase radiation dose. Spectral Photon-Counting Computed Tomography (SPCCT) has recently emerged as novel and promising modality the field diagnostic radiology. SPCCT is able to distinguish between two contrast agents referred multicolor because, when measuring three...
The purpose of this study was to investigate a preclinical spectral photon-counting CT (SPCCT) prototype compared conventional for pulmonary imaging. A custom-made lung phantom, including nodules different sizes and shapes, scanned with SPCCT in standard high-resolution (HR-CT) mode. Volume estimation evaluated by linear regression. Shape similarity the Dice coefficient. Spatial resolution investigated via MTF each imaging system. In-vivo rabbit images from system were subjectively reviewed....
Over the last decade, dual-energy CT scanners have gone from prototypes to clinically available machines, and spectral photon counting are following. They require a specific reconstruction process, consisting of two steps: material decomposition tomographic reconstruction. Image-based methods perform reconstruction, then decomposition, while projection-based first, As an alternative, 'one-step inversion' been proposed, which simultaneously. Unfortunately, one-step typically slower than their...
To validate in vitro the capability of a high-spatial-resolution prototype spectral photon-counting computed tomography (SPCCT) scanner to differentiate between 2 contrast agents and assess vivo image quality feasibility peritoneal cavity rats using simultaneously within vascular compartments.The authors performed SPCCT imaging (100 mAs, 120 kVp) with energy bin thresholds set 30, 51, 64, 72, 85 keV on custom-made polyoxymethylene cylindrical phantom consisting tubes dilutions both groups...