A5035002612- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Sleep and related disorders
- Biochemical Analysis and Sensing Techniques
- Regulation of Appetite and Obesity
- Restless Legs Syndrome Research
- Neuropeptides and Animal Physiology
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Neuroscience of respiration and sleep
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Thyroid Disorders and Treatments
- Adipose Tissue and Metabolism
- Retinopathy of Prematurity Studies
- Olfactory and Sensory Function Studies
- Molecular Communication and Nanonetworks
- Optical Imaging and Spectroscopy Techniques
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer, Stress, Anesthesia, and Immune Response
- Hypothalamic control of reproductive hormones
- Photoacoustic and Ultrasonic Imaging
University of Pennsylvania
2020-2024
California University of Pennsylvania
2018-2024
University of California, Irvine
2005-2023
University of Lausanne
2023
Howard Hughes Medical Institute
2015-2019
University of California, Berkeley
1982-2019
Ewha Womans University
2000
Association for Asian Studies
1982
University of Michigan
1982
University of Chicago
1982
Mammalian sleep consists of distinct rapid eye movement (REM) and non-REM (NREM) states. The midbrain region ventrolateral periaqueductal gray (vlPAG) is known to be important for gating REM sleep, but the underlying neuronal mechanism not well understood. Here, we show that activating vlPAG GABAergic neurons in mice suppresses initiation maintenance while consolidating NREM partly through their projection dorsolateral pons. Cell-type-specific recording calcium imaging reveal most are...
The basal forebrain (BF) plays key roles in multiple brain functions, including sleep-wake regulation, attention, and learning/memory, but the long-range connections mediating these functions remain poorly characterized. Here we performed whole-brain mapping of both inputs outputs four BF cell types - cholinergic, glutamatergic, parvalbumin-positive (PV+) somatostatin-positive (SOM+) GABAergic neurons mouse brain. Using rabies virus -mediated monosynaptic retrograde tracing to label...
We have recently shown that Neuropeptide S (NPS) can promote arousal and induce anxiolytic-like effects after central administration in rodents. Another study reported a number of natural polymorphisms the human NPS receptor gene. Some these were associated with increased risk asthma possibly other forms atopic diseases, but physiological consequences mutations remain unclear. One produces an Asn-Ile exchange first extracellular loop protein, C-terminal splice variant was found overexpressed...
Drug addiction is mediated by complex neuronal processes that converge on the shell of nucleus accumbens (NAcSh). The NAcSh receives inputs from lateral hypothalamus (LH), where self-stimulation can be induced. Melanin-concentrating hormone (MCH) produced mainly in LH, and its receptor (MCH1R) highly expressed NAcSh. We found that, NAcSh, MCH1R coexpressed with dopamine receptors (D1R D2R), MCH increases spike firing when both D1R D2R are activated. Also, injecting potentiates...
In our daily life, we are exposed to uncontrollable and stressful events that disrupt sleep. However, the underlying neural mechanisms deteriorating quality of non-rapid eye movement sleep (NREMs) REM largely unknown. Here, show in mice acute psychosocial stress disrupts by increasing brief arousals (microarousals [MAs]), reducing spindles, impairing infraslow oscillations spindle band electroencephalogram during NREMs, while REMs. This poor was reflected an increased number calcium...
Abstract Rapid-eye-movement (REM) sleep is a distinct behavioral state associated with vivid dreaming and memory processing. Phasic bursts of electrical activity, measurable as spike-like pontine (P)-waves, are hallmark REM implicated in consolidation. However, the brainstem circuits regulating P-waves, their interactions generating sleep, remain largely unknown. Here, we show that an excitatory population dorsomedial medulla (dmM) neurons expressing corticotropin-releasing-hormone (CRH)...
The neuropeptide orphanin FQ/nociceptin (OFQ/N) has been shown to counteract several effects of endogenous and exogenous opioids, it proposed as an opioid-modulating agent involved in the development morphine tolerance dependence. However, conflicting results have obtained from animal models using different protocols induce tolerance. Here, we report that both genetic pharmacological blockade OFQ/N signaling can effectively prevent knockout mice injected daily with low doses (10 mg/kg) fail...
Rapid eye movement sleep (REMs) is characterized by activated electroencephalogram (EEG) and muscle atonia, accompanied vivid dreams. REMs homeostatically regulated, ensuring that any loss of compensated a subsequent increase in its amount. However, the neural mechanisms underlying homeostatic control are largely unknown. Here, we show GABAergic neurons preoptic area hypothalamus projecting to tuberomammillary nucleus (POA GAD2 →TMN neurons) crucial for regulation mice. POA most active...
A salient feature of mammalian sleep is the alternation between rapid eye movement (REM) and non-REM (NREM) sleep. However, how these two stages influence each other thereby regulate timing REM episodes still largely unresolved. Here, we developed a statistical model that specifies relationship subsequent NREM to quantify affects following duration its electrophysiological features in mice. We show lognormal mixture well describes preceding influences amount till next episode. The supports...
Deficits in sensorimotor gating measured by prepulse inhibition (PPI) of the startle have been known as characteristics patients with schizophrenia and related neuropsychiatric disorders. PPI disruption is thought to rely on activity mesocorticolimbic dopaminergic system inhibited most antipsychotic drugs. These drugs however act also at nigrostriatal pathway exert adverse locomotor responses. Finding a way inhibit mesocorticolimbic- without affecting nigrostriatal-dopaminergic may thus be...