A5062315564- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Obstructive Sleep Apnea Research
- EEG and Brain-Computer Interfaces
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience of respiration and sleep
- Receptor Mechanisms and Signaling
- Alzheimer's disease research and treatments
- Ion channel regulation and function
- Sleep and related disorders
- interferon and immune responses
- S100 Proteins and Annexins
- Computational Drug Discovery Methods
- Vestibular and auditory disorders
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Neuropeptides and Animal Physiology
- Multiple Sclerosis Research Studies
- Functional Brain Connectivity Studies
Howard Hughes Medical Institute
2019-2022
University of California, Berkeley
2019-2022
University Medical Center of the Johannes Gutenberg University Mainz
2014-2021
Johannes Gutenberg University Mainz
2014-2021
University of Washington
2015
Studying the biology of sleep requires accurate assessment state experimental subjects, and manual analysis relevant data is a major bottleneck. Recently, deep learning applied to electroencephalogram electromyogram has shown great promise as scoring method, approaching limits inter-rater reliability. As with any machine algorithm, inputs classifier are typically standardized in order remove distributional shift caused by variability signal collection process. However, scientific data,...
Sleep disturbances are strongly associated with cardiovascular diseases. Baroreflex, a basic regulation mechanism, is modulated by sleep-wake states. Here, we show that neurons at key stages of baroreflex pathways also promote sleep. Using activity-dependent genetic labeling, tagged in the nucleus solitary tract (NST) activated blood pressure elevation and confirmed their barosensitivity optrode recording calcium imaging. Chemogenetic or optogenetic activation these promoted non-REM sleep...
Abstract Aberrant activity of local functional networks underlies memory and cognition deficits in Alzheimer’s disease (AD). Hyperactivity was observed microcircuits mice AD-models showing plaques, also recently early stage AD mutants prior to amyloid deposition. However, effects on cortical remain unresolved. Using two-photon calcium imaging, we found altered temporal distributions (burstiness) the spontaneous layer II/III visual cortex neurons, a mouse model familial (5xFAD), before plaque...
Many structures of the mammalian CNS generate propagating waves electrical activity early in development. These are essential to development, mediating a variety developmental processes, such as axonal outgrowth and pathfinding, synaptogenesis, maturation ion channel receptor properties. In mouse cerebral cortex, occur between embryonic day 18 postnatal 8 originate pacemaker circuits septal nucleus piriform cortex. Here we show that genetic knock-out major synthetic enzyme for GABA, GAD67,...
Spontaneous activity in the developing brain helps refine neuronal connections before arrival of sensory-driven activity. In mouse neocortex during first postnatal week, waves spontaneous originating from pacemaker regions septal nucleus and piriform cortex propagate through neocortex. Using high-speed Ca(2+) imaging to resolve spatiotemporal dynamics wave propagation parasagittal slices, we show that hippocampus can act as an additional source neocortical waves. Some originate remain...
Abstract Studying the biology of sleep requires accurate assessment state experimental subjects, and manual analysis relevant data is a major bottleneck. Recently, deep learning applied to electroencephalogram electromyogram has shown great promise as scoring method, approaching limits inter-rater reliability. As with any machine algorithm, inputs classifier are typically standardized in order remove distributional shift caused by variability signal collection process. However, scientific...
Cortical development involves the structuring of network features by genetically programmed molecular signaling pathways. Additionally, spontaneous ion channel activity refines neuronal connections. We examine Ca(2+) fluctuations in first postnatal week normal mouse neocortex and that expressing knockout transcription factor T-brain-1 (Tbr1): a molecule cortical patterning differentiation excitatory neurons. In cortex, glutamatergic neurons express Tbr1 just before onset population...