A5018009853- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Sleep and related disorders
- Olfactory and Sensory Function Studies
- Pain Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Heart Rate Variability and Autonomic Control
- Time Series Analysis and Forecasting
- Cleft Lip and Palate Research
- Mindfulness and Compassion Interventions
- Photoreceptor and optogenetics research
- Nicotinic Acetylcholine Receptors Study
- Spaceflight effects on biology
- Genetics, Aging, and Longevity in Model Organisms
- Neonatal and fetal brain pathology
- Neural and Behavioral Psychology Studies
- Developmental and Educational Neuropsychology
- Biochemical Analysis and Sensing Techniques
- Child Nutrition and Feeding Issues
- Non-Invasive Vital Sign Monitoring
- Tracheal and airway disorders
- Epilepsy research and treatment
University of Lausanne
2017-2025
Netherlands Institute for Neuroscience
2024-2025
University of Pennsylvania
2023
Universidad de Los Andes
2017-2022
University of Amsterdam
2021
Amsterdam University Medical Centers
2021
Stanford University
2018
Universidad de Los Andes
2018
Universidad Autonoma de Manizales
2014-2017
To understand what makes sleep vulnerable in disease, it is useful to look at how wake-promoting mechanisms affect healthy sleep. Wake-promoting neuronal activity inhibited during non-rapid-eye-movement (NREMS). However, sensory vigilance persists NREMS animals and humans, suggesting that wake promotion could remain functional. Here, we demonstrate consolidated mouse a brain state with recurrent fluctuations of the neurotransmitter noradrenaline on ∼50-s timescale thalamus. These occurred...
Sleep is a growing area of research interest in medicine and neuroscience. Actually, one major concern to find correlation between several physiologic variables sleep stages. There scientific agreement on the characteristics five stages human sleep, based EEG analysis. Nevertheless, manual stage classification still most widely used approach. This work proposes new automatic method unsupervised feature algorithms recently developed, entropy measures. scheme extracts metrics from records...
Although traumatic brain injury (TBI) acutely disrupts the cortex, most TBI-related disabilities reflect secondary injuries that accrue over time. The thalamus is a likely site of damage because its reciprocal connections with cortex. Using mouse model mild TBI (mTBI), we found chronic increase in C1q expression specifically corticothalamic system. Increased colocalized neuron loss and inflammation correlated disruption sleep spindles emergence epileptic activities. Blocking counteracted...
Sleep affects brain activity globally, but many cortical sleep waves are spatially confined. Local rhythms serve area-specific needs and functions; however, mechanisms controlling locality unclear. We identify the thalamic reticular nucleus (TRN) as a source for local, sensory-cortex-specific non-rapid-eye-movement (NREMS) in mouse. Neurons optogenetically identified sensory TRN sectors showed stronger repetitive burst discharge compared to non-sensory cells due higher of low-threshold Ca2+...
Abstract The noradrenergic locus coeruleus (LC) is vital for brain states underlying wakefulness, whereas its roles sleep remain uncertain. Combining mouse sleep-wake monitoring, behavioral manipulations, LC fiber photometry and closed-loop optogenetics, we found that neuronal activity partitioned non-rapid-eye-movement (NREMS) into alternating autonomic rule the NREMS-REMS cycle. High levels generated an autonomic-subcortical arousal state facilitated cortical microarousals, while low were...
Frequent nightly arousals typical for sleep disorders cause daytime fatigue and present health risks. As such are often short, partial, or occur locally within the brain, reliable characterization in rodent models of human patients is challenging. We found that EEG spectral composition non-rapid eye movement (NREMS) healthy mice shows an infraslow (~50 s) interval over which microarousals appear preferentially. NREMS could hence be vulnerable to abnormal on this time scale. Chronic pain...
Rapid eye movement sleep (REMs) is characterized by activated electroencephalogram (EEG) and muscle atonia, accompanied vivid dreams. REMs homeostatically regulated, ensuring that any loss of compensated a subsequent increase in its amount. However, the neural mechanisms underlying homeostatic control are largely unknown. Here, we show GABAergic neurons preoptic area hypothalamus projecting to tuberomammillary nucleus (POA GAD2 →TMN neurons) crucial for regulation mice. POA most active...
Parasympathetic nervous system activity, vital for restorative sleep, is influenced by vagal sensory afferents, but how these shape brain-body correlates of sleep remains open. We investigated this combining neuron (VSN) stimulation with EEG/EMG, heart rate, temperature, and noradrenergic locus coeruleus (LC) population activity measures. Opto-/chemogenetic VSN manipulations in Vglut2-Cre mice were validated via vitro synaptic physiology, cFos expression, rate Chemogenetic during the resting...
Rapid eye movement sleep (REMs) is characterized by activated electroencephalogram (EEG) and muscle atonia, accompanied vivid dreams. REMs homeostatically regulated, ensuring that any loss of compensated a subsequent increase in its amount. However, the neural mechanisms underlying homeostatic control are largely unknown. Here, we show GABAergic neurons preoptic area hypothalamus projecting to tuberomammillary nucleus (POA GAD2 →TMN neurons) crucial for regulation mice. POA most active...
Abstract Sleep is both a state of disconnection from the environment and critical period for restoration. But how does sleep balance responsiveness with protection key functions? The infraslow fluctuation sigma power (ISFS)—the clustering spindles over 10-100 seconds—is thought to regulate this trade-off in rodents. However, organization arousal memory reactivation markers within human ISFS its conservation younger ages remain unclear. This study characterizes childhood young adulthood (N =...
Summary One promising approach towards understanding what makes sleep vulnerable in disease is to look at how wake-promoting mechanisms affect healthy sleep. Wake-promoting neuronal activity inhibited during non-REM (NREMS). However, many mammalian species, including humans, show recurrent moments of fragility which sensory reactivity elevated. Wake-related could thus remain active NREMS, but its roles dynamic variations unknown. Here, we demonstrate that mouse NREMS a brain state with...
Abstract Closed-loop acoustic stimulation (CLAS) during sleep has shown to boost slow wave (SW) amplitude and spindle power. Moreover, SW have been classified based on different processes of neuronal synchronization. Thus, types events may distinct functional roles be differentially affected by external stimuli. However, the synchronization CLAS are not well understood. Here, we studied effect dissociation two features in electroencephalogram (topological spread slope). We evaluated...
ABSTRACT Rapid-eye-movement sleep (REMs) is characterized by activated electroencephalogram (EEG) and muscle atonia, accompanied vivid dreams. REMs homeostatically regulated, ensuring that any loss of compensated a subsequent increase in its amount. However, the neural mechanisms underlying homeostatic control are largely unknown. Here, we show GABAergic neurons preoptic area hypothalamus projecting to tuberomammillary nucleus (POA GAD2 →TMN neurons) crucial for regulation REMs. POA most...
Caffeine is a highly consumed stimulant of the nervous system. Although caffeine has diverse effects on different brain functions, little known about specific pharmacokinetics this substance in brain. For instance, most studies that assessed distribution rat have only measured levels cortex and striatum but not more areas.Aims: The purpose work was to measure concentration blood regions (i.e. cortex, striatum, hippocampus, cerebellum brainstem) at times after administration single...
Abstract Chronic pain patients frequently suffer from sleep disturbances. Improvement of quality alleviates pain, but neurophysiological mechanisms underlying disturbances require clarification to advance therapeutic strategies. causes high-frequency electrical activity in pain-processing cortical areas that could disrupt the normal process low-frequency rhythm generation. We found spared-nerve-injury (SNI) mouse model, mimicking human neuropathic had preserved sleep-wake behavior. However,...
Rapid-eye-movement sleep (REMs) is characterized by activated electroencephalogram (EEG) and muscle atonia, accompanied vivid dreams. REMs homeostatically regulated, ensuring that any loss of compensated a subsequent increase in its amount. However, the neural mechanisms underlying homeostatic control are largely unknown. Here, we show GABAergic neurons preoptic area hypothalamus projecting to tuberomammillary nucleus (POA GAD2 →TMN neurons) crucial for regulation REMs. POA most active...