A5078262137- Sleep and Wakefulness Research
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Sleep and related disorders
- Epilepsy research and treatment
- Neuroscience of respiration and sleep
- Sleep and Work-Related Fatigue
- Advanced Chemical Sensor Technologies
- Multisensory perception and integration
- Circadian rhythm and melatonin
- Neurological disorders and treatments
- Neuroscience and Music Perception
- Neuroscience and Neuropharmacology Research
- Cardiovascular Syncope and Autonomic Disorders
- Functional Brain Connectivity Studies
- Heart Rate Variability and Autonomic Control
- Radio Wave Propagation Studies
- Atomic and Subatomic Physics Research
University Children's Hospital Zurich
2013-2025
University of Zurich
2023-2025
University Hospital of Zurich
2023-2025
Abstract It is hypothesized that deep sleep essential for restoring the brain’s capacity to learn efficiently, especially in regions heavily activated during day. However, causal evidence humans has been lacking due inability deprive one target area while keeping natural pattern intact. Here we introduce a novel approach focally perturb motor cortex, and investigate consequences on behavioural neurophysiological markers of neuroplasticity arising from dedicated practice. We show undergo...
Summary Objective In CSWS (continuous spike waves during sleep) activation of slow wave sleep has been causally linked to neuropsychological deficits, but the pathophysiologic mechanisms are still unknown. healthy subjects, overnight decrease slope in NREM (non–rapid eye movement) brain recovery regain optimal cognitive performance. Here, we investigated whether electrophysiologic hallmark , sleep, is related an alteration slope, and if this location density waves. Methods a retrospective...
Abstract Adequate sleep quantity and quality is required to maintain vigilance, cognitive learning processes. A decrease of preflight on the International Space Station (ISS) has been reported. Recent counter-measures have implemented better regulate opportunities ISS. In our study, astronauts were allocated enough time for night before recordings. However, proper recovery, also critical. Unfortunately, data yet be acquired from Here, we investigate pressure markers during wakefulness in...
The use of information-based measures to assess changes in conscious state is an increasingly popular topic. Though recent results have seemed justify the merits such methods, little has been done investigate applicability children. For our work, we used approximate entropy (ApEn), a measure previously shown correlate with when applied electroencephalogram (EEG), and sought confirm whether reported trends adult ApEn values across wake sleep were present Besides validating prior findings that...
Vyazovskiy and colleagues found in rats' multi-unit recordings brief periods of silence (off-states) local populations cortical neurons during wakefulness which closely resembled the characteristic off-states sleep. These became more global frequent with increasing sleep pressure were associated well-known increase theta activity under deprivation surface EEG. Moreover, occurrence such was related to impaired performance. While these animal experiments based on intracranial recordings, we...
Slow wave activity (SWA, 0.5-4.5 Hz) is a well-established marker for sleep pressure in adults. Recent studies have shown that increasing reflected by an increased synchronized firing pattern of cortical neurons, which can be measured the slope slow waves. Thus we aimed at investigating whether waves might provide alternative to study homeostatic regulation during early human development.
Abstract Deep sleep supports several restorative functions and has emerged as a potential therapeutic target in neurodegenerative disorders, such Parkinson’s disease (PD). Phase-targeted auditory stimulation (PTAS) is non-invasive method for enhancing slow waves of deep sleep, measurable by increased slow-wave activity (SWA; spectral power 0.75–4.5 Hz). Here, we report the first study investigating whether PTAS can be successfully applied PD patients with subjective disturbance. We conducted...
Abstract Conflicting evidence exists regarding the role of targeted slow-wave phase in determining direction and spatial specificity activity (SWA) modulation via phase-targeted auditory stimulation (PTAS) during sleep. To reconcile these discrepancies, we re-analyzed high-density electroencephalography (hd-EEG) data from previous studies, focusing on SWA responses to stimuli presented with varying inter-stimulus intervals (ISIs). Our analysis reveals that ISI is a primary determinant...
A reduction in sleep spindles, a major electrophysiological characteristic of Non-Rapid Eye Movement sleep, has been suggested as potential biomarker schizophrenia. While research primarily focused on the spindle quantity, recent studies have begun to explore their temporal dynamics throughout night. In healthy individuals, spindles fluctuate an infraslow ~50-second timescale, alternating between phases high and low activity. This fluctuation is referred sigma power (ISFS), which modulated...
Slow waves, the electroencephalographic (EEG) hallmark of deep sleep, can be systematically manipulated by acoustic stimulation: stimulation time-locked to down phase slow waves reduces, whereas up increases waves. Spike-waves during sleep seem related raising question whether spike-waves influenced such stimulation. In five pediatric patients, all-night EEG was recorded, combined with real-time wave detection. Throughout night, performed in a 3 × 5-min-block design (no...
The restorative function of sleep has been linked to a net reduction in synaptic strength. slope slow-waves, major characteristic non-rapid eye movement (NREM) sleep, shown directly reflect strength, when accounting for amplitude changes across the night. In this study, we aimed investigate overnight course development an age-, amplitude-, and region-dependent manner. All-night high-density electroencephalography data were analyzed cross-sectional population 60 healthy participants age range...
ABSTRACT Up-phase-targeted auditory stimulation (up-PTAS) during slow-wave sleep has become a valuable tool for modulating slow oscillations and slow-oscillation-spindle-coupling in favor of overnight memory retention. Developing effective, automated protocols translation into more naturalistic or clinical settings is an ongoing challenge, especially given that current PTAS their behavioral effects vary greatly between different studies. Here, we assessed the electrophysiological...
Abstract Sleep is both a state of disconnection from the environment and critical period for restoration. But how does sleep balance responsiveness with protection key functions? The infraslow fluctuation sigma power (ISFS)—the clustering spindles over 10-100 seconds—is thought to regulate this trade-off in rodents. However, organization arousal memory reactivation markers within human ISFS its conservation younger ages remain unclear. This study characterizes childhood young adulthood (N =...
Abstract Synaptic downscaling during sleep, a physiological process to restore synaptic homeostasis and maintain learning efficiency healthy brain development, has been related reduction of the slope sleep slow waves (SSW). However, such seems not be reflected in high‐amplitude SSW. Recently we have shown reduced SSW slopes hormonal treatment (adrenocorticotrophic hormone, prednisolone) patients with West syndrome (WS). Yet, whether this was successful or reflects specific effect hormone...
Abstract Background Enhancing slow waves, the electrophysiological (EEG) manifestation of non-rapid eye movement (NREM) sleep, might offer therapeutic benefits for patients with Parkinson’s disease (PD) by improving sleep quality and slowing progression. Phase-targeted auditory stimulation (PTAS) is an approach to enhance which are detected in surface EEG signal real-time. Objective We aimed test whether local-field potential subthalamic nucleus (STN-LFP) can be used detect frontal waves...