A5100331719- Autism Spectrum Disorder Research
- Family and Disability Support Research
- Prenatal Screening and Diagnostics
- Genetics and Neurodevelopmental Disorders
- Child Development and Digital Technology
- Obesity, Physical Activity, Diet
- Genomic variations and chromosomal abnormalities
- BRCA gene mutations in cancer
- Autophagy in Disease and Therapy
- Nutritional Studies and Diet
- Cancer-related gene regulation
- Cognitive Abilities and Testing
- Food Security and Health in Diverse Populations
- Global Cancer Incidence and Screening
- Ethics in Clinical Research
- Children's Physical and Motor Development
- Peripheral Nerve Disorders
- Congenital heart defects research
- Memory and Neural Mechanisms
- Supercapacitor Materials and Fabrication
- Nutrition and Health in Aging
- Bone and Joint Diseases
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Advanced Sensor and Energy Harvesting Materials
China University of Geosciences
2025
China University of Petroleum, Beijing
2025
Shanghai Institute of Materia Medica
2024-2025
Chinese Academy of Sciences
2024-2025
Panzhihua Central Hospital
2025
South China University of Technology
2025
East Carolina University
2014-2024
Yunnan Agricultural University
2024
Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine
2024
Jilin University
2024
Forty-one 1,3,4-thiadiazolyl-containing thiazolidine-2,4-dione derivatives (MY1–41) were designed and synthesized as protein tyrosine phosphatase 1B (PTP1B) inhibitors with activity against diabetes mellitus (DM). All compounds presented potential PTP1B inhibitory activities, half-maximal concentration (IC50) values ranging from 0.41 ± 0.05 to 4.68 0.61 μM, compared that of the positive control lithocholic acid (IC50 = 9.62 0.14 μM). The most potent compound, MY17 μM), was a reversible,...
Gout is a prevalent metabolic disorder characterized by urate crystal accumulation in joints, leading to acute arthritis and tophi formation. Despite advancements management, the incidence prevalence of gout have been increasing globally, particularly China. This study analyzed data from Global Burden Disease Injuries Risk Factors Study (GBD) evaluate trends 1990 2021. Statistical analyses were conducted using R Joinpoint software, while ARIMA model was employed for forecasting future...
Abstract Utilization of electro‐responsive biomaterials with antibacterial properties is advantageous for facilitating septic wound healing and tissue regeneration. However, the dose‐response effects electrical stimuli from these materials against bacteria are not rigorously characterized, achieving synergy bactericidal pro‐regenerative remains a major challenge. Here, graded series flexible BaTiO 3 /P(VDF‐TrFE) electroactive nanocomposite membranes (EMs) developed varying surface charge...
Background This study aims to use six nutrition-related indicators assess the relationship between nutritional status and risk of COPD as well all-cause mortality rate, determine most reliable predictive indicators. Methods Data from National Health Nutrition Examination Survey (NHANES) spanning years 2013 2018 were extracted. Nutritional was evaluated using Controlling (CONUT) score, Geriatric Risk Index (GNRI), Advanced Lung Cancer Inflammation (ALI), Prognostic (PNI), Triglycerides (TG) ×...
With the proposal of carbon peaking and neutrality strategy, concept green low-carbon began to take root, influence foreign direct investment on progress technology is attracting more attention. Based panel data 30 provinces in China from 2011 2020, this study examines effect FDI its geographic policy heterogeneity by using generalized least square regression method, discusses mechanism combined with moderating trade opening. The results show that: (1) introduction has a significant positive...
Indole-fused polycycles are common in natural products and bioactive molecules, yet their concise efficient synthesis remains challenging, especially for compounds with multiple stereocenters. Herein, we report the application of a chiral CpxRhIII catalyst enantioselective C–H activation/[4+2] annulation indoles bicyclic alkenes. This catalytic system exhibits high enantioselectivity broad functional group tolerance operates under benign conditions. The scope this methodology encompasses...
This study aimed to investigate the mechanism of lncRNA-KCNQ1OT1 on macrophage polarization ameliorate particle-induced osteolysis. We used polymethylmethacrylate (PMMA) induce primary bone marrow-derived macrophages (BMMs) obtained from mice and RAW264.7 cell line, found that tumor necrosis factor-alpha (TNF-α) concentration inducible nitric oxide synthase (iNOS) expression was increased, while interleukin (IL)-10 Arg1 were decreased in PMMA-induced cells. KCNQ1OT1 IL-10 both suppressed...
In the United States, prenatal genetic testing (PGT) for Autism Spectrum Disorders (ASD) is currently available via clinical services. Such may inform parents about their unborn child's risk ASD, prepare birth of an affected infant, and allow them to arrange early interventions. Although PGT autism has potential benefits, associated ethical, legal, social implications (ELSI) should be considered. This first qualitative study employed a hypothetical scenario explore attitudes toward...
Dihydroartemisinin (DHA), a derivate of artemisinin, is an effective antimalarial agent. DHA has been shown to exert anticancer activities numerous cancer cells in the past few years, while exact molecular mechanisms remain be elucidated, especially esophageal cancer.Crystal violet assay was conducted determine cell viability human line Eca109 treated with DHA. Tumor-bearing nude mice were employed evaluate effect vivo. Soft agar and crystal assays used measure tumorigenicity cells. Flow...
Facing global water scarcity, exacerbated by population growth and environmental contamination, there is an imperative to enhance access resources. The accelerated evolution of atmospheric harvesting (AWH) technology...
This study explores the dynamic evolution of physical fitness data in college students from a biomechanics perspective, analyzing impact different exercise intensities on health. Using biomechanical modeling methods, combined with Euler-Lagrange equation, joint torque calculation formula, and health index variation model, experiments were designed collected. The process under was simulated, measuring indicators such as change rate, peak torque, energy efficiency ratio, distribution,...
To address the complex synthesis and metal agglomeration for partially sulfurized heterostructures, a cellulose pore adsorption strategy is proposed to fabricate CoFe/Co8FeS8 heterostructures in N/S-doped biocarbon cavities. In absence of chelating agents, porosity active groups enable preadsorption ions N/S sources willow catkin via ion hydrogen bonding, respectively. The spatial confinement provided by biopores facilitates incomplete sulfuration while effectively preventing...
This study aimed to explore the relationship between physical fitness and cognitive control in Chinese children, with a focus on gender differences moderating role of family support for activity (FSFPA). employed cross-sectional design assess 148 children aged 12–14 years from Guangzhou. Physical was evaluated using National Student Fitness Standard, (FSFPA) measured validated Family Support Activity Scale, assessed Stroop color-word task, Go/No-Go task-cue paradigm. The statistical analyses...
This study aims to explore the relationship between physical fitness levels and cognitive control in Chinese early adolescents, focusing on longitudinal analysis understand how these variables interact over time. Additionally, investigates moderating effect of gender this relationship. The included 160 junior high students (aged 12-14) with gender-balanced participation (64 boys, 79 girls retained after attrition). Utilizing a two-wave design, baseline assessments (T1: March-April 2023)...
Family health history (FHH) plays a significant role in early disease detection and prevention. Although Asian Americans are the fastest growing U.S. immigrant group, no data exists regarding Chinese Americans' (the largest subgroup) views use of FHH. This study examines this important issue.Forty-nine adults from southern American communities participated qualitative, semi-structured, in-depth interview study. Interviews were audio recorded, transcribed, analyzed with content analysis...
Polybrominated diphenyl ethers (PBDEs) have been detected ubiquitously in biological and environmental samples. Growing epidemiological data suggested the obvious correlation of PBDEs exposure with adverse health outcomes toward human beings, but exact molecular mechanism(s) are limited. Especially, toxicological information regarding metabolites is missing. Thereafter, this study intends to explore unidentified cell death modalities caused by reactive quinone-type metabolite, PBDEQ. We...